The First Report of Iranian Registry of Patients with Spinal Muscular Atrophy.
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Mansouri Vahid, Heidari Morteza, Bemanalizadeh Maryam, Azizimalamiri Reza, Nafissi Shahriar, Akbari Masood Ghahvechi, Barzegar Mohammad, Moayedi Ali Reza, Badv Reza Shervin, Mohamadi Mahmood, Tavasoli Ali Reza, Amirsalari Susan, Khajeh Ali, Inaloo Soroor, Fatehi Farzad, Hosseinpour Sareh, Babaei Meisam, Hosseini Seyed Ahmad, Mahdi Hosseiny Seyyed Mohammad, Fayyazi Afshin, Hosseini Firoozeh, Toosi Mehran Beiraghi, Khosroshahi Nahid, Ghabeli Homa, Biglari Habibeh Nejad, Kakhki Simin Khayatzadeh, Mirlohi Seyed Hossein, Bidabadi Elham, Mohammadi Bahram, Omrani Abdolmajid, Sedighi Mostafa, Vafaee-Shahi Mohammad, Rasulinezhad Maryam, Hoseini Seyyed Mohamad, Movahedinia Mojtaba, Rezaei Zahra, Karimi Parviz, Farshadmoghadam Hossein, Anvari Saeed, Yaghini Omid, Nasiri Jafar, Zamani Gholamreza, Ashrafi Mahmoud Reza
Аннотация
OBJECTIVE: To describe the key demographic, clinical, and genetic characteristics of patients with SMA registered in the Iranian Registry of SMA (IRSMA).
METHODS: IRSMA has been established since 2018, and the demographic, clinical, and genetic characteristics of patients with SMA were recorded according to the methods of treat neuromuscular disease (TREAT-NMD) project.
RESULTS: By October 1, 2022, 781 patients with 5q SMA were registered. Of them, 164 patients died, the majority of them had SMA type 1 and died during the first 20 months of life. The median survival of patients with type 1 SMA was 23 months. The consanguinity rate in 617 alive patients was 52.4%, while merely 24.8% of them had a positive family history. The most common type of SMA in live patients was type 3. Morbidities were defined as having scoliosis (44.1%), wheelchair dependency (36.8%), tube feeding (8.1%), and requiring mechanical ventilation (9.9%). Most of the registered patients had a homozygous deletion of SMN1, while the frequency of patients with higher copy numbers of SMN2, was less in more severe types of the disease. Earlier onset of the disease was significantly seen in patients with lower copy numbers of SMN2. The neuronal apoptosis inhibitory protein (NAIP) gene deletion was associated with a higher incidence of more severe types of SMA, higher dependency on ventilators, tube feeding, and earlier onset of the disease.
CONCLUSIONS: The IRSMA is the first established Iranian nationwide registry of patients with SMA. Using this registry, decision-makers, researchers, and practitioners can precisely understand the epidemiology, characteristics, and genetics of patients with SMA in Iran.