[New interdisciplinary S3 guidelines on deletion syndrome 22q11.2, a genetic disease predisposing to neuropsychiatric morbidity].

The deletion syndrome 22q11.2 is one of the most frequent genetic syndromes in humans, with a prevalence of 1:2500 [1]. The syndrome is particularly relevant for neurology, psychiatry and child and adolescent psychiatry due to a massive genetic predisposition to neuropsychiatric disorders that has been proven in recent years. Somatic symptoms are highly variable and can be diverse. Congenital heart defects, otorhinolaryngologic (ENT) abnormalities, parathyroid dysfunction and orthopedic abnormalities are particularly frequent and typical. In addition, many affected individuals suffer from susceptibility to infections. Almost all affected children show developmental disorders.