Transplantation proceedings · 2025
Evaluation of Long-Term Ocular Findings in Liver Transplant Patients: Comparison of Pediatric and Adult Age Groups.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод в очереди
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Öcal Olgar, Çetinkaya Yaprak Aslı, Demirok Zeki, Bahar Tevfik Serhat, Özkan Ömer, Özkan Özlenen, Demiryılmaz İsmail, Kısaoğlu Abdullah, Yaprak Muhittin
Аннотация
PURPOSE: To assess long-term ocular complications and identify factors affecting these complications who have undergone liver transplantation.
METHODS: We included 147 patients who had a complete ophthalmologic examination at least 1 year after liver transplantation. The patients were divided into two groups: adult (group 1) and pediatric liver transplant patients (group 2). Data collected included best corrected visual acuity, intraocular pressure (measured with Full Auto Tonometer TX-F; Topcon), refractive error (measured with KR-8900; Topcon, Tokyo, Japan), slit-lamp examination of the anterior segment, and dilated fundus examination for both eyes. Refractive error, lens opacity, eye dryness, pterygium pinguecula, arcus lipoides, corneal calcification, macular drusen, central serous chorioretinopathy, hypertensive retinopathy, and diabetic retinopathy were all recorded. All patients received a maintenance immunosuppressive protocol consisting of combinations of steroids, calcineurin inhibitors, mycophenolate mofetil, and mammalian target of rapamycin inhibitors.
RESULTS: Our study included 106 recipients in group 1 and 41 recipients in group 2. In group 1, 8 participants (7.5%); in group 2, 5 participants (12.2%) needed myopic correction. Additionally, 12 participants (11.3%) in group 1 required hyperopic correction, compared to 2 participants (4.9%) in group 2. No statistically significant difference was found between the two groups (P > .05). Regarding anterior segment findings, 18 participants (16%) in group 1 and 1 recipients (2.4%) in group 2 were diagnosed with dry eye, with a statistically significant higher incidence in group 1 (P = .02). The rates of arcus lipoides, pterygium, pinguecula, cataract, and glaucoma were similar in both groups (P > .05). For posterior segment findings were higher in the adult group, no statistically significant difference was found (P > .05). We identified dry eyes and cataracts as the most common ocular complications and more prevalent in group 1.
CONCLUSION: Different ocular complications involving the anterior and posterior segments can be seen in the long-term after liver transplantation. The fact that postoperative anterior and posterior segment complications were statistically higher in the adult age group suggests that the risk of postoperative complications may be related to age and age-related systemic diseases such as diabetes, hypertension; or cumulative drug use.
METHODS: We included 147 patients who had a complete ophthalmologic examination at least 1 year after liver transplantation. The patients were divided into two groups: adult (group 1) and pediatric liver transplant patients (group 2). Data collected included best corrected visual acuity, intraocular pressure (measured with Full Auto Tonometer TX-F; Topcon), refractive error (measured with KR-8900; Topcon, Tokyo, Japan), slit-lamp examination of the anterior segment, and dilated fundus examination for both eyes. Refractive error, lens opacity, eye dryness, pterygium pinguecula, arcus lipoides, corneal calcification, macular drusen, central serous chorioretinopathy, hypertensive retinopathy, and diabetic retinopathy were all recorded. All patients received a maintenance immunosuppressive protocol consisting of combinations of steroids, calcineurin inhibitors, mycophenolate mofetil, and mammalian target of rapamycin inhibitors.
RESULTS: Our study included 106 recipients in group 1 and 41 recipients in group 2. In group 1, 8 participants (7.5%); in group 2, 5 participants (12.2%) needed myopic correction. Additionally, 12 participants (11.3%) in group 1 required hyperopic correction, compared to 2 participants (4.9%) in group 2. No statistically significant difference was found between the two groups (P > .05). Regarding anterior segment findings, 18 participants (16%) in group 1 and 1 recipients (2.4%) in group 2 were diagnosed with dry eye, with a statistically significant higher incidence in group 1 (P = .02). The rates of arcus lipoides, pterygium, pinguecula, cataract, and glaucoma were similar in both groups (P > .05). For posterior segment findings were higher in the adult group, no statistically significant difference was found (P > .05). We identified dry eyes and cataracts as the most common ocular complications and more prevalent in group 1.
CONCLUSION: Different ocular complications involving the anterior and posterior segments can be seen in the long-term after liver transplantation. The fact that postoperative anterior and posterior segment complications were statistically higher in the adult age group suggests that the risk of postoperative complications may be related to age and age-related systemic diseases such as diabetes, hypertension; or cumulative drug use.