Is there any effect of lycopene's preventing peritoneal adhesion formation in rats: an experimental study.

OBJECTIVE

Effects of lycopene in prevention of intra-abdominal adhesion formation in a rat model.

METHODS

Twenty-eight rats were divided into four groups consisting of 7 rats each. Group 1 (only adhesion), Group 2 (adhesion + corn oil), Group 3 (adhesion + 5 mg/kg lycopene), Group 4 (adhesion + 20 mg/kg lycopene). Adhesion score, histopathology, vascular endothelial growth factor (VEGF) H-score, malondialdehyde (MDA), total antioxidant capacity, and VEGF values were measured.

RESULTS

There were significantly higher extent, severity, degree, and total adhesion scores in the control and corn-oil group than in the low lycopene and high lycopene group. VEGF H-scores were significantly lower in lycopene-given groups, regardless of dose. When the low lycopene and high lycopene groups were compared in terms of anti-VEGF H-score, no significant difference was observed. Malondialdehyde levels were statistically significantly lower in the control and high lycopene group.

CONCLUSIONS

Biochemical parameters, histopathological examination, and adhesion scoring revealed that lycopene significantly reduced adhesion formation.