Activation of the impaired nasal mucociliary transport in children: preliminary report.

The effect of HR-6 containing adenosine triphosphate on the impaired mucociliary transport was studied in 13 children. The main symptoms in the children were chronic non-allergic rhinitis, recurrent otitis media, recurrent or chronic maxillary sinusitis and infections of the lower respiratory tract. Initially, the mucociliary transport rate ranged from 0 to 5.6 mm/min, mean 1.8 mm/min. HR-6 increased the mucociliary transport rate by 1.3-3.5, mean 2.0 mm/min. The corresponding figures for the placebo were from 0 to 0.4, mean 0.2 mm/min. These preliminary results indicate further studies with HR-6 in children with impaired mucociliary function are necessary.