Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
Cerebral oxygen extraction fraction as a physiological biomarker in vascular cognitive impairment: A study in older adults enriched for small vessel diseases.
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Song Jie, Shi Wen, Suconic Julia, Hazel Kaisha, Pottanat George, Jones Ebony, Deane Tyler, Sharma Archana, Xu Cuimei, Oishi Kumiko, Gou Yifan, Hu Zhiyi, Li Xin, Rosenberg Paul, Kalyani Rita, Moghekar Abhay, Yasar Sevil, Lin Doris, Albert Marilyn, Lu Hanzhang, Jiang Dengrong
Аннотация
INTRODUCTION: Vascular cognitive impairment and dementia (VCID) is a common cause of cognitive impairment, yet validated biomarkers, particularly those reflecting vascular function, remain lacking. Oxygen extraction fraction (OEF), which reflects the functional status of cerebral small vessels, is a potential physiological biomarker for VCID. We tested this hypothesis in older adults enriched for small vessel diseases, controlling for Alzheimer's disease (AD) co-pathology.
METHODS: Comprehensive cognitive, plasma, and imaging data were collected from 81 older adults with at least one vascular risk factor. OEF in major cerebral veins was quantified using magnetic resonance imaging. Associations between OEF and cognition, vascular, and plasma AD biomarkers were evaluated.
RESULTS: In this VCID-enriched cohort, poorer global cognition and executive function were associated with elevated OEF, but not with plasma phosphorylated tau 217. Increased OEF correlated with more vascular risk factors and greater white matter hyperintensity volume.
DISCUSSION: Our findings suggest that elevated OEF in individuals with vascular risks is a physiological biomarker for VCID.
METHODS: Comprehensive cognitive, plasma, and imaging data were collected from 81 older adults with at least one vascular risk factor. OEF in major cerebral veins was quantified using magnetic resonance imaging. Associations between OEF and cognition, vascular, and plasma AD biomarkers were evaluated.
RESULTS: In this VCID-enriched cohort, poorer global cognition and executive function were associated with elevated OEF, but not with plasma phosphorylated tau 217. Increased OEF correlated with more vascular risk factors and greater white matter hyperintensity volume.
DISCUSSION: Our findings suggest that elevated OEF in individuals with vascular risks is a physiological biomarker for VCID.