[Clinical characteristics and surgical outcomes of pediatric retinal detachment associated with Stickler syndrome].

Objective: To analyze the clinical characteristics, surgical treatment, and prognosis of pediatric retinal detachment associated with Stickler syndrome. Methods: This retrospective case series study included 20 eyes from 18 patients aged ≤18 years diagnosed with Stickler syndrome-related retinal detachment at the Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University between January 1, 2018 and August 1, 2023. All patients underwent comprehensive ophthalmological evaluations. The personalized retinal reattachment surgery plan was selected based on individual factors, including age, visual acuity, intraocular pressure, anterior segment status, and vitreoretinal conditions. The follow-up duration ranged from 12 to 72 months. Postoperative outcomes, including visual acuity, intraocular pressure, retinal reattachment status, and complications, were assessed. Results: There were 16 males (17 eyes) and 2 females (3 eyes), with a mean age of 9 (5, 11) years. All 20 eyes (100%) presented with rhegmatogenous retinal detachment, of which 13 eyes (65.0%) exhibited C1-D2 proliferative vitreoretinopathy, 11 eyes (55.0%) had total retinal detachment, 7 eyes (35.0%) showed giant retinal tears, and 6 eyes (30.0%) were complicated by choroidal detachment. Surgical interventions included pars plana vitrectomy (PPV) with silicone oil tamponade in 11 eyes (55.0%), scleral buckling alone in 5 eyes (25.0%), combined PPV with silicone oil tamponade and scleral buckling in 3 eyes (15.0%), and PPV with C3F8 gas tamponade in 1 eye (5.0%). Two eyes (10.0%) experienced recurrent retinal detachment after the initial surgery and required a secondary procedure. Among the 14 eyes treated with silicone oil tamponade, successful oil removal was achieved in 7 eyes (50.0%). At the final follow-up, the median best-corrected visual acuity significantly improved to logMAR 1.00 (0.70, 1.19) from preoperative logMAR 2.0 (1.33, 2.60) (Z=-3.83, P<0.001). The anatomical success rate of retinal reattachment was 100%, with no significant postoperative complications observed in any patient. Conclusion: Retinal detachment associated with Stickler syndrome predominantly manifests as rhegmatogenous retinal detachment, frequently complicated by severe proliferative vitreoretinopathy, giant retinal tears, and choroidal detachment. Selecting an appropriate surgical approach based on distinct clinical characteristics can effectively achieve retinal reattachment, improve vision function, and promote normal development of the affected eye.