Retina (Philadelphia, Pa.) · 2025
A COMBINATION REGIMEN OF INTRAVITREAL CLINDAMYCIN WITH DEXAMETHASONE, SYSTEMIC CO-TRIMOXAZOLE AND STEROIDS FOR MACULAR TOXOPLASMA RETINOCHOROIDITIS IN IMMUNOCOMPETENT CASES.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Satavasia Sushree, Mishra Akshay, Jadhav Vishal, Abhishek Talluri Ronnie, Kelgaonkar Anup, Patel Anamika, Basu Soumyava, Pathengay Avinash
Аннотация
PURPOSE: To study the role of intravitreal clindamycin with dexamethasone as an adjuvant to systemic co-trimoxazole and steroids in macular Toxoplasma retinochoroiditis.
METHODS: Retrospective study of Toxoplasma retinochoroiditis cases from January 2014 to December 2021 treated with a combination of oral and intravitreal therapy in immunocompetent patients.
RESULTS: Thirty-nine eyes of 39 patients were included in this study after meeting the inclusion criteria with the mean age of presentation being 25.25 years (±9.30; range 4-52 years). Male preponderance with 61.53% of male patients (n = 24) and 38.47% of female patients (n = 15) was observed. Active retinitis was unilateral in all eyes (20 right eyes; 19 left eyes). Five lines of improvement in visual acuity on Early Treatment Diabetic Retinopathy Study (ETDRS) chart were noted at final visit. The location of retinitis was either foveal (n = 24) or extrafoveal (n = 15). The mean size of retinitis was 1.24 ± 0.70-disc diameter. The mean number of injections given was 1.79 with a mean interval of 1.39 weeks.
CONCLUSION: Intravitreal clindamycin with dexamethasone when used as an adjunct to systemic therapy showed resolution of retinitis in all cases with visual improvement.
METHODS: Retrospective study of Toxoplasma retinochoroiditis cases from January 2014 to December 2021 treated with a combination of oral and intravitreal therapy in immunocompetent patients.
RESULTS: Thirty-nine eyes of 39 patients were included in this study after meeting the inclusion criteria with the mean age of presentation being 25.25 years (±9.30; range 4-52 years). Male preponderance with 61.53% of male patients (n = 24) and 38.47% of female patients (n = 15) was observed. Active retinitis was unilateral in all eyes (20 right eyes; 19 left eyes). Five lines of improvement in visual acuity on Early Treatment Diabetic Retinopathy Study (ETDRS) chart were noted at final visit. The location of retinitis was either foveal (n = 24) or extrafoveal (n = 15). The mean size of retinitis was 1.24 ± 0.70-disc diameter. The mean number of injections given was 1.79 with a mean interval of 1.39 weeks.
CONCLUSION: Intravitreal clindamycin with dexamethasone when used as an adjunct to systemic therapy showed resolution of retinitis in all cases with visual improvement.
Предметные рубрики MeSH
HumansClindamycinDexamethasoneRetrospective StudiesFemaleMaleIntravitreal InjectionsToxoplasmosis, OcularAdultMiddle AgedGlucocorticoidsYoung AdultVisual AcuityAdolescentDrug Therapy, CombinationAnti-Bacterial AgentsChild, PreschoolChildTrimethoprim, Sulfamethoxazole Drug CombinationChorioretinitisEye Infections, ParasiticToxoplasmaMacula LuteaFollow-Up StudiesTreatment Outcome