Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2006
Association of polymorphisms of IGF1R and genes in the transforming growth factor- beta /bone morphogenetic protein pathway with bacteremia in sickle cell anemia.
СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
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Adewoye Adeboye H, Nolan Vikki G, Ma Qianli, Baldwin Clinton, Wyszynski Diego F, Farrell John J, Farrer Lindsay A, Steinberg Martin H
Аннотация
Infection and bacteremia are common in sickle cell disease. We hypothesized that, consistent with evidence for the genetic modulation of other disease complications, the risk of developing bacteremia might also be genetically modulated. Accordingly, we studied the association of single nucleotide polymorphisms (SNPs) in candidate genes with the risk of bacteremia in sickle cell anemia. We found significant associations with SNPs in IGF1R and genes of the TGF-beta /BMP pathway (BMP6, TGFBR3, BMPR1A, SMAD6 and SMAD3). We suggest that both IGF1R and the TGF-beta /BMP pathway could play important roles in immune function in sickle cell anemia and their polymorphisms may help identify a "bacteremia-prone" phenotype.
Предметные рубрики MeSH
AdolescentAdultAnemia, Sickle CellBacteremiaBone Morphogenetic Protein 6Bone Morphogenetic Protein Receptors, Type IBone Morphogenetic ProteinsChildChild, PreschoolFemaleGenetic Predisposition to DiseaseHumansLinkage DisequilibriumMalePolymorphism, GeneticProteoglycansReceptor, IGF Type 1Receptors, Transforming Growth Factor betaSmad3 ProteinSmad6 ProteinTransforming Growth Factor beta