Medical sciences (Basel, Switzerland) · 2026
Evaluation of Echinacea Leaf Extract and Allantoin Based Topical Formulations in an Imiquimod-Induced Psoriasis-like Model.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Fati Cristina Burlou-Nagy, Pallag Annamaria, Vicaș Laura Grațiela, Gligor Octavia, Horvath Tünde, Lelesz Beáta, Hegedűs Csaba, Leiter Imre, Juhász Béla, Kiss Rita
Аннотация
BACKGROUND/OBJECTIVES: Psoriasis is a chronic inflammatory disorder characterized by epidermal hyperproliferation and immune dysregulation. This study evaluated the topical efficacy of Echinacea leaf extract and allantoin compared to a corticosteroid (mometasone furoate) in an imiquimod (IMQ)-induced psoriasis-like model in Sprague-Dawley rats.
METHODS: Psoriasiform lesions were induced by daily application of 5% IMQ for six days, followed by six weeks of treatment with one of the following formulations: Echinacea cream or gel, allantoin cream or gel, and mometasone. Disease severity was assessed using a modified Psoriasis Area and Severity Index (PASI) and histological analysis.
RESULTS: All groups developed psoriasis-like lesions; however, Echinacea cream produced the most pronounced and sustained reduction in PASI scores, with near-complete macroscopic recovery. Echinacea gel and allantoin cream showed moderate effects, while allantoin gel and mometasone exhibited limited efficacy. Histological findings supported these results, with Echinacea cream restoring near-normal epidermal architecture.
CONCLUSIONS: In conclusion, topical Echinacea leaf extract formulations, particularly the cream formulation, demonstrated superior efficacy in reducing psoriasis-like skin inflammation and restoring epidermal structure compared to allantoin based treatments and mometasone. These findings suggest that Echinacea-derived bioactive compounds may represent promising candidates for the development of alternative or adjunctive therapies for inflammatory skin diseases.
METHODS: Psoriasiform lesions were induced by daily application of 5% IMQ for six days, followed by six weeks of treatment with one of the following formulations: Echinacea cream or gel, allantoin cream or gel, and mometasone. Disease severity was assessed using a modified Psoriasis Area and Severity Index (PASI) and histological analysis.
RESULTS: All groups developed psoriasis-like lesions; however, Echinacea cream produced the most pronounced and sustained reduction in PASI scores, with near-complete macroscopic recovery. Echinacea gel and allantoin cream showed moderate effects, while allantoin gel and mometasone exhibited limited efficacy. Histological findings supported these results, with Echinacea cream restoring near-normal epidermal architecture.
CONCLUSIONS: In conclusion, topical Echinacea leaf extract formulations, particularly the cream formulation, demonstrated superior efficacy in reducing psoriasis-like skin inflammation and restoring epidermal structure compared to allantoin based treatments and mometasone. These findings suggest that Echinacea-derived bioactive compounds may represent promising candidates for the development of alternative or adjunctive therapies for inflammatory skin diseases.