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DOI 10.1038/s41467-025-63078-x

Медицинская библиотека · Nature communications · 2025

Neural correlates of human fear conditioning and sources of variability in 2199 individuals.

Radua Joaquim, Savage Hannah S, Vilajosana Enric, Jamieson Alec, Abler Birgit, Åhs Fredrik, Beckers Tom, Cardoner Narcís, Cisler Josh M, Diniz Juliana B, Bach Dominik R, Elsenbruch Sigrid, Greening Steven G, Holt Daphne J, Kaczkurkin Antonia N, Keil Andreas, Kindt Merel, Koch Kathrin, LaBar Kevin S, Lam Charlene L, Larson Christine L, Lonsdorf Tina B, Merz Christian J, McLaughlin Katie A, Neria Yuval, Pine Daniel S, van Reekum Carien M, Shackman Alexander J, Soriano-Mas Carles, Spoormaker Victor I, Stout Daniel M, Straube Benjamin, Straube Thomas, Tuominen Lauri, Visser Renée M, Ahumada Laura, Arolt Volker, Batistuzzo Marcelo C, Bazán Paulo R, Biggs Emma E, Cano Marta, Chavarría-Elizondo Pamela, Cooper Samuel E, Dannlowski Udo, de la Peña-Arteaga Víctor, DeCross Stephanie N, Domschke Katharina, Ehlers Mana R, Graner John L, Hamm Alfons O, Herrmann Martin J, Huggins Ashley A, Icenhour Adriane, Juaneda-Seguí Asier, Junghoefer Markus, Kircher Tilo, Koelkebeck Katja, Kuhn Manuel, Labrenz Franziska, Lissek Shmuel M, Lotze Martin, Lueken Ulrike, Margraf Jürgen, Martínez-Zalacaín Ignacio, Moeck Robert, Morriss Jayne, Ortuño María, Pittig Andre, Porta-Casteras Daniel, Richter Jan, Ridderbusch Isabelle C, Rief Winfried, Roesmann Kati, Rosén Jörgen, Rußmann Alena N, Sjouwerman Rachel, Spohrs Jennifer, Ströhle Andreas, Suarez-Jimenez Benjamin, Ulrich Martin, Wittchen Hans-Ulrich, Zhu Xi, Waller Lea, Walter Henrik, Thompson Paul M, Bas-Hoogendam Janna Marie, Groenewold Nynke A, J Stein Dan, Van der Wee Nic J, Dunsmoor Joseph E, Marquand Andre F, J Harrison Ben, Fullana Miquel A

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Аннотация

Pavlovian fear conditioning is a fundamental process in both health and disease. We investigate its neural correlates and sources of variability using harmonized functional magnetic resonance imaging data from 2199 individuals across nine countries, including 1888 healthy individuals and 311 with anxiety-related or depressive disorders. Using mega-analysis and normative modeling, we show that fear conditioning consistently engages brain regions within the "central autonomic-interoceptive" or "salience" network. Several task variables strongly modulate activity in these regions, contributing to variability in neural responses. Additionally, brain activation patterns differ between healthy individuals and those with anxiety-related or depressive disorders, with distinct profiles characterizing specific disorders such as post-traumatic stress disorder and obsessive-compulsive disorder. While the neural correlates of fear conditioning are highly generalizable at the population level, variability arises from differences in task design and clinical status, highlighting the importance of methodological diversity in capturing fear learning mechanisms.

Для цитирования: Radua Joaquim, Savage Hannah S, Vilajosana Enric, Jamieson Alec, Abler Birgit, Åhs Fredrik, Beckers Tom, Cardoner Narcís, Cisler Josh M, Diniz Juliana B, Bach Dominik R, Elsenbruch Sigrid, Greening Steven G, Holt Daphne J, Kaczkurkin Antonia N, Keil Andreas, Kindt Merel, Koch Kathrin, LaBar Kevin S, Lam Charlene L, Larson Christine L, Lonsdorf Tina B, Merz Christian J, McLaughlin Katie A, Neria Yuval, Pine Daniel S, van Reekum Carien M, Shackman Alexander J, Soriano-Mas Carles, Spoormaker Victor I, Stout Daniel M, Straube Benjamin, Straube Thomas, Tuominen Lauri, Visser Renée M, Ahumada Laura, Arolt Volker, Batistuzzo Marcelo C, Bazán Paulo R, Biggs Emma E, Cano Marta, Chavarría-Elizondo Pamela, Cooper Samuel E, Dannlowski Udo, de la Peña-Arteaga Víctor, DeCross Stephanie N, Domschke Katharina, Ehlers Mana R, Graner John L, Hamm Alfons O, Herrmann Martin J, Huggins Ashley A, Icenhour Adriane, Juaneda-Seguí Asier, Junghoefer Markus, Kircher Tilo, Koelkebeck Katja, Kuhn Manuel, Labrenz Franziska, Lissek Shmuel M, Lotze Martin, Lueken Ulrike, Margraf Jürgen, Martínez-Zalacaín Ignacio, Moeck Robert, Morriss Jayne, Ortuño María, Pittig Andre, Porta-Casteras Daniel, Richter Jan, Ridderbusch Isabelle C, Rief Winfried, Roesmann Kati, Rosén Jörgen, Rußmann Alena N, Sjouwerman Rachel, Spohrs Jennifer, Ströhle Andreas, Suarez-Jimenez Benjamin, Ulrich Martin, Wittchen Hans-Ulrich, Zhu Xi, Waller Lea, Walter Henrik, Thompson Paul M, Bas-Hoogendam Janna Marie, Groenewold Nynke A, J Stein Dan, Van der Wee Nic J, Dunsmoor Joseph E, Marquand Andre F, J Harrison Ben, Fullana Miquel A. Neural correlates of human fear conditioning and sources of variability in 2199 individuals.. Nature communications. 2025. DOI: 10.1038/s41467-025-63078-x.

Предметные рубрики MeSH

HumansFearMagnetic Resonance ImagingMaleFemaleAdultConditioning, ClassicalBrainYoung AdultMiddle AgedStress Disorders, Post-TraumaticBrain MappingAnxiety DisordersAdolescentObsessive-Compulsive Disorder
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