Recenti progressi in medicina · 2026
[Pharmacovigilance and antibiotic resistance: analysis of real-world data from the Rizzoli Orthopedic Institute in the management of antibiotic-related adverse drug reactions in musculoskeletal diseases.].
Аннотация на английскомСтатьяНазвание и аннотация: Перевод в очереди
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D'Alonzo Daniela, Trombetta Laura, Matino Federica, Di Lella Elisa, Luppi Massimiliano, Di Pede Sara, Iovino Paola, Melfi Maria Antonietta, Petriglieri Irene, Righi Francesco, Celozzi Rosa, Gulisano Giovanni, Sassoli Valeria
Аннотация
BACKGROUND: Antibiotics can cause adverse drug reactions (ADRs) and hypersensitivity reactions (HSRs) through a variety of mechanisms. At our hospital, patients admitted with musculoskeletal tissue infection are followed by infectious disease consultants. The pharmacist only provides the therapy after verifying the correspondence (molecule, dosage and posology) of the motivated request (RMP) with the infectious disease consultancy. The aim was to identify adverse drug reactions, report them and providing training.
METHODS: Following the pharmacist's analysis of the infectious disease consultations, ADRs relating to antibiotics were identified and they were entered into the Network of Pharmacovigilance data from Italy, also managing any integrations, and subsequently collected in an Excel file. A qualitative analysis of clinical status, suspected drugs, adverse drug reactions (ADRs) description and its degree of seriousness were collected. A training course was organised "Rischio infettivo: Strumenti, best practice e approfondimenti".
RESULTS: The most involved drugs were daptomycin and piperacillin tazobactam; the most observed adverse reactions were dermatological manifestations, eosinophilia, increased transaminases. Most of the reports were not serious. They organized 13 training courses and formats 400 health workers.
CONCLUSIONS: Our experience confirms an under-reporting and has highlighted that the contribution to reporting by hospital doctors and nurses is closely related to the valuable work of awareness and support of hospital pharmacists. They assist clinicians in detecting phenomena that may underline the onset of adverse reactions and, consequently, carry out a reporting activity that guarantees useful information for the management of antibiotic therapy. Disseminating and discussing the results of pharmacovigilance is an aspect that motivates the healthcare professional to report. Working to increase the identification of ADRs and the consequent reporting allows us to contribute to the appropriate prescription of antibiotics, avoiding the onset of resistance and also the exposure of the individual patient to serious and disabling side effects.
METHODS: Following the pharmacist's analysis of the infectious disease consultations, ADRs relating to antibiotics were identified and they were entered into the Network of Pharmacovigilance data from Italy, also managing any integrations, and subsequently collected in an Excel file. A qualitative analysis of clinical status, suspected drugs, adverse drug reactions (ADRs) description and its degree of seriousness were collected. A training course was organised "Rischio infettivo: Strumenti, best practice e approfondimenti".
RESULTS: The most involved drugs were daptomycin and piperacillin tazobactam; the most observed adverse reactions were dermatological manifestations, eosinophilia, increased transaminases. Most of the reports were not serious. They organized 13 training courses and formats 400 health workers.
CONCLUSIONS: Our experience confirms an under-reporting and has highlighted that the contribution to reporting by hospital doctors and nurses is closely related to the valuable work of awareness and support of hospital pharmacists. They assist clinicians in detecting phenomena that may underline the onset of adverse reactions and, consequently, carry out a reporting activity that guarantees useful information for the management of antibiotic therapy. Disseminating and discussing the results of pharmacovigilance is an aspect that motivates the healthcare professional to report. Working to increase the identification of ADRs and the consequent reporting allows us to contribute to the appropriate prescription of antibiotics, avoiding the onset of resistance and also the exposure of the individual patient to serious and disabling side effects.