Journal of neuroscience methods · 2026
Feasibility of integrated transcranial doppler ultrasound-near-infrared spectroscopy to measure cerebral haemodynamics in dementia, delirium, and depression (the VESPAR Project): A pilot study.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Edwards Olivia, Nicholls Jennifer K, Desai Bhavisha, Panerai Ronney B, Ball James D, Sensier Yvonne, Mukaetova-Ladinska Elizabeta, Beishon Lucy
Аннотация
BACKGROUND: Transcranial Doppler ultrasonography (TCD) and near-infrared spectroscopy (NIRS) are indirect measures of neurovascular coupling (NVC). No studies have assessed the feasibility of an integrated TCD-NIRS approach to measure NVC in patients with dementia, delirium, and depression.
NEW METHOD: TCD-NIRS was trialled in 10 healthy volunteers, 11 patients with depression, 8 with dementia, and 5 with delirium. Participants underwent continuous cerebral blood velocity measurements, measured from the dominant middle cerebral artery (MCAv) and non-dominant posterior cerebral artery (PCAv), at rest and in response to four cognitive tasks. Heart rate (HR), end-tidal carbon dioxide (EtCO2), blood pressure (BP), prefrontal oxygenated (HbO2) and deoxygenated (HbR) haemoglobin levels were measured.
RESULTS: Resting mean MCAv differed significantly between groups (healthy volunteers: 53.9 (SD=8.09) cm/s, depression: 41.9 (9.31) cm/s (p = 0.041), dementia: 42.5 (13.7) cm/s, (0.150) delirium: 32.6 (7.48) cm/s (p = 0.002), after correction for age and BP (p = 0.012). There were no significant differences in resting PCAv, BP, EtCO2, HR, or prefrontal oxygenation. Participants with delirium were unable to complete the task-activated section of the protocol. All four tasks evoked indirect changes in NVC in healthy volunteers, and in patients with depression and dementia; only HbR differed in the depression group relative to the dementia group (p = 0.021).
COMPARISON WITH EXISTING METHODS: While these techniques have been used individually in the different patient groups, they have not been used in conjunction to assess differences in NVC between all three groups.
CONCLUSIONS: An integrated TCD-NIRS protocol in this pilot study was feasible in these patient groups to measure NVC, but not in delirium.
NEW METHOD: TCD-NIRS was trialled in 10 healthy volunteers, 11 patients with depression, 8 with dementia, and 5 with delirium. Participants underwent continuous cerebral blood velocity measurements, measured from the dominant middle cerebral artery (MCAv) and non-dominant posterior cerebral artery (PCAv), at rest and in response to four cognitive tasks. Heart rate (HR), end-tidal carbon dioxide (EtCO2), blood pressure (BP), prefrontal oxygenated (HbO2) and deoxygenated (HbR) haemoglobin levels were measured.
RESULTS: Resting mean MCAv differed significantly between groups (healthy volunteers: 53.9 (SD=8.09) cm/s, depression: 41.9 (9.31) cm/s (p = 0.041), dementia: 42.5 (13.7) cm/s, (0.150) delirium: 32.6 (7.48) cm/s (p = 0.002), after correction for age and BP (p = 0.012). There were no significant differences in resting PCAv, BP, EtCO2, HR, or prefrontal oxygenation. Participants with delirium were unable to complete the task-activated section of the protocol. All four tasks evoked indirect changes in NVC in healthy volunteers, and in patients with depression and dementia; only HbR differed in the depression group relative to the dementia group (p = 0.021).
COMPARISON WITH EXISTING METHODS: While these techniques have been used individually in the different patient groups, they have not been used in conjunction to assess differences in NVC between all three groups.
CONCLUSIONS: An integrated TCD-NIRS protocol in this pilot study was feasible in these patient groups to measure NVC, but not in delirium.