Challenges and Opportunities in Cronkhite-Canada Syndrome Research: A Bibliometric Analysis Based on the Web of Science Core Collection.

BACKGROUND Cronkhite-Canada syndrome (CCS) is a rare gastrointestinal polyposis disorder with more than 500 cases worldwide. It is associated with high mortality rates and complex pathogenesis. Owing to its rarity and fragmented evidence base, the overall publication patterns and evolving research focus of CCS have not been systematically mapped. This study performed a Web of Science Core Collection (WoSCC)-based bibliometric analysis and knowledge mapping to summarize research output, collaboration patterns, and topic evolution in CCS. MATERIAL AND METHODS Based on 256 English publications on CCS retrieved from the WoSCC, bibliometric analysis and visualization were conducted using CiteSpace and VOSviewer to examine publication trends, collaboration networks, and keyword evolution. RESULTS Research on CCS showed a fluctuating growth trend, with a slowed growth observed after 2023. The United States, China, and Japan contributed the highest number of publications. Collaboration network analysis suggested relatively limited international cooperation, and high-yield institutions showed low centrality (centrality <0.1). Keyword co-occurrence and burst analyses indicated an evolving research focus from disease characterization to mechanistic exploration and clinical management in recent years. CONCLUSIONS This WoSCC-based bibliometric analysis summarizes publication patterns, major contributors, and evolving research topics in CCS. These findings reflect trends in the indexed literature and bibliometric indicators rather than direct advances in clinical outcomes or mechanisms. Future studies can benefit from strengthening international collaboration and integrating multicenter evidence to support more robust mechanistic and clinical investigations in CCS.