The Medical journal of Malaysia · 2025
The effect of serum eosinophilia and lymphocytosis on functional outcomes of Hirschsprung disease patients after Duhamel procedure.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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Kumari D, Afrila H, Putri I F, Tohari A I, Harfanie D F, Izzati Z S, Aditama L I, Puspitawati I, Makhmudi A, Gunadi
Аннотация
INTRODUCTION: Hirschsprung disease (HSCR) is due to the failure of enteric nervous system precursors to colonize the distal intestine in embryonic development, with surgical treatment like the Duhamel procedure as a definitive intervention. However, complications leading to functional disorders may occur, especially with increased eosinophil levels. No studies have assessed the effect of peripheral blood eosinophil and lymphocyte counts on functional outcomes in HSCR patients post-Duhamel procedure.
MATERIALS AND METHODS: This observational retrospective study involved 54 patients undergoing Duhamel procedures from January 2014 to June 2020 at Dr. Sardjito Hospital. Patient records were analyzed using the Mann-Whitney U test for continuous variables and the Chi-Square test for categorical variables.
RESULTS: The majority of patients had normal eosinophil levels (78.8%) and normal lymphocyte counts (96.2%). Functional outcomes revealed that 49 patients (94.2%) had no voluntary bowel movements (VBM), 45 patients (86.5%) did not experience constipation, and 48 subjects (92.3%) had no soiling issues. There was no significant association was found between eosinophilia and functional outcomes in Hirschsprung disease patients after Duhamel procedure (p > 0.05). Similarly, there was no significant association between lymphocytosis and functional outcomes in these patients following Duhamel procedure (p > 0.05) CONCLUSION: The functional outcomes of patients with Hirschsprung disease post-Duhamel procedure at our institution are favorable with most having normal eosinophil and lymphocyte counts. Eosinophilia and lymphocytosis might not significantly affect the outcomes of Hirschsprung disease patients after undergoing the Duhamel procedure at Dr. Sardjito Hospital.
MATERIALS AND METHODS: This observational retrospective study involved 54 patients undergoing Duhamel procedures from January 2014 to June 2020 at Dr. Sardjito Hospital. Patient records were analyzed using the Mann-Whitney U test for continuous variables and the Chi-Square test for categorical variables.
RESULTS: The majority of patients had normal eosinophil levels (78.8%) and normal lymphocyte counts (96.2%). Functional outcomes revealed that 49 patients (94.2%) had no voluntary bowel movements (VBM), 45 patients (86.5%) did not experience constipation, and 48 subjects (92.3%) had no soiling issues. There was no significant association was found between eosinophilia and functional outcomes in Hirschsprung disease patients after Duhamel procedure (p > 0.05). Similarly, there was no significant association between lymphocytosis and functional outcomes in these patients following Duhamel procedure (p > 0.05) CONCLUSION: The functional outcomes of patients with Hirschsprung disease post-Duhamel procedure at our institution are favorable with most having normal eosinophil and lymphocyte counts. Eosinophilia and lymphocytosis might not significantly affect the outcomes of Hirschsprung disease patients after undergoing the Duhamel procedure at Dr. Sardjito Hospital.