Prescription Trends for Bipolar Disorder With and Without Comorbid Substance Use and Anxiety Disorders: A Global Bipolar Cohort Collaborative Study.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Yocum Anastasia K, Alda Martin, Aouizerate Bruno, Aubin Valerie, Bellivier Frank, Belzeaux Raoul, Berk Michael, Biernacka Joanna M, Budde Monika, Burdick Katherine E, Chang Yun-Hsuan, Coombes Brandon J, Courtet Philippe, Dalkner Nina, Diaz-Byrd Claudia, Dubertret Caroline, Etain Bruno, Fico Giovanna, Fullerton Janice M, Godin Ophelia, Gordon-Smith Katherine, Haffen Emmanuel, Januel Dominique, Keramatian Kamyar, Leboyer Marion, Lefrere Antoine, Llorca Pierre-Michel, Majd Marzieh, Mitchell Philip B, Mwangi Benson, Olie Emilie, Overs Bronwyn J, Petite Joanne, Polosan Mircea, Rey Romain, Roberts Gloria, Roux Paul, Samalin Ludovic, Schwan Raymund, Serretti Alessandro, Soares Jair C, Sperry Sarah H, Strawbridge Rebecca, Stross Tatjana, Vieta Eduard, Walter Michel, Williams Lana J, Wu Mon-Ju, Yatham Lakshmi N, Young Allan H, Yrondi Antoine, Zunta-Soares Giovana B, Frye Mark A, McInnis Melvin G, Singh Balwinder
Аннотация
METHODS: Fourteen cohorts contributed aggregate data on pharmacotherapy, demographics, diagnostic subtypes, and comorbidities. Proportional meta-analyses using generalized linear mixed models were conducted to examine prescription trends and identify clinical differences.
RESULTS: The sample (N = 11,521) was 60% female and 84% Caucasian. Participants were categorized into four mutually exclusive groups based on comorbidity status: those with comorbid AX only, comorbid SUD only, both AX and SUD, or neither. The AX+SUD subgroup showed higher rates of attention-deficit/hyperactivity disorder (ADHD), post-traumatic stress disorder (PTSD), rapid cycling, obesity, and unemployment, reflecting a more severe clinical profile. Regional variations were notable: North American cohorts reported higher prevalence of AX and SUD than European and Pacific cohorts. Antidepressants use for AX were more common in Europe and the Pacific, while North American prescribing patterns were more variable. Benzodiazepine use was high among individuals with SUD across all regions. Lithium and first-generation antipsychotic prescriptions varied, with higher rates observed in Europe.
CONCLUSIONS: Findings underscore the heterogeneity of BD and the influence of comorbid AX and SUD on illness burden and treatment. Regional prescribing variations underscore the need for context-specific guidelines. Gaps in data on medication-assisted treatment for SUD point to areas for future research. These insights can support more individualized and effective care for complex BD presentations.