Indian pediatrics · 2025
Effect of Antiretroviral Therapy and Vitamin E Supplementation on Total Antioxidant Capacity in Children Living with HIV.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Kumar K Jai, Dewan Pooja, Kar Rajarshi, Almeida Edelbert Anthonio, Harit Deepika, Kotru Mrinalini, Yadav Mukesh
Аннотация
OBJECTIVES: To assess the total antioxidant capacity (TAC) in children living with HIV (CLHIV) and to evaluate the effect of antiretroviral therapy (ART) and vitamin E supplementation on TAC.
METHODS: The study included CLHIV on ART ≥ 2 years, ART-naïve CLHIV and healthy controls. CLHIV on ART ≥ 2 years received vitamin E supplements in addition to combination ART for three months duration. TAC levels, α-tocopherol levels, hemogram, red blood cell indices, viral load and CD4 counts were estimated at baseline and after three months of ART.
RESULTS: A total of 25 children were included per group. The median (IQR) TAC levels (mM Trolox Equiv) were significantly lower in CLHIV ART for ≥ 2 years [6.32 (8.7, 13.28)], compared to controls [11.89 (8.15, 14.38)] and ART-naïve CLHIV [12.69 (7.61, 16.78)]. TAC levels increased after 3 months of starting ART [15.57 (9.90, 17.49); P = 0.178]. α-tocopherol levels (µmol/L) were significantly different among the three groups, viz controls [72 (28.86, 80)], ART-naïve CLHIV [40.24 (30.36, 71.59)] and CLHIV on ART ≥ 2 years [16.77 (13.15, 20.21)]. Three months of vitamin E supplementation, failed to produce a significant increase in TAC levels [10.4 (7.28, 14.92)] while the red cell indices and CD4 counts improved significantly with a marginal reduction in HIV viral load.
CONCLUSION: Prolonged ART reduced antioxidant capacity. Three months of vitamin E supplementation produced marginal increase in TAC levels.
TRIAL REGISTRY: CTRI/2022/12/047960 [Registered on: 08/12/2022] Trial Registered Prospectively.
METHODS: The study included CLHIV on ART ≥ 2 years, ART-naïve CLHIV and healthy controls. CLHIV on ART ≥ 2 years received vitamin E supplements in addition to combination ART for three months duration. TAC levels, α-tocopherol levels, hemogram, red blood cell indices, viral load and CD4 counts were estimated at baseline and after three months of ART.
RESULTS: A total of 25 children were included per group. The median (IQR) TAC levels (mM Trolox Equiv) were significantly lower in CLHIV ART for ≥ 2 years [6.32 (8.7, 13.28)], compared to controls [11.89 (8.15, 14.38)] and ART-naïve CLHIV [12.69 (7.61, 16.78)]. TAC levels increased after 3 months of starting ART [15.57 (9.90, 17.49); P = 0.178]. α-tocopherol levels (µmol/L) were significantly different among the three groups, viz controls [72 (28.86, 80)], ART-naïve CLHIV [40.24 (30.36, 71.59)] and CLHIV on ART ≥ 2 years [16.77 (13.15, 20.21)]. Three months of vitamin E supplementation, failed to produce a significant increase in TAC levels [10.4 (7.28, 14.92)] while the red cell indices and CD4 counts improved significantly with a marginal reduction in HIV viral load.
CONCLUSION: Prolonged ART reduced antioxidant capacity. Three months of vitamin E supplementation produced marginal increase in TAC levels.
TRIAL REGISTRY: CTRI/2022/12/047960 [Registered on: 08/12/2022] Trial Registered Prospectively.