The journal of the Royal College of Physicians of Edinburgh · 2022
Gastrointestinal involvement of common variable immunodeficiency: A diagnostic challenge to the physician.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Gangadharan Harikrishnan, Paul Vipin Joseph, Ravi Roopa, Arasan Saravana Sreenivasan, Venugopal Suryagayathri, Sundaram Sankar, Kandiyil Sunil Kumar, Yadav Reetika Malik, Madkaikar Manisha, George Josemon
Аннотация
A 35-year-old male presented with fatigue for 1 month and was found to have megaloblastic anaemia. Further evaluation showed low globulin levels and pan hypogammaglobulinemia. Past history was significant for chronic small bowel diarrhoea and bilateral genu valgum deformity from childhood. Hence, a malabsorption syndrome with a probable antibody deficiency was suspected. An upper gastrointestinal (GI) endoscopy was done, which revealed chronic atrophic gastritis with Helicobacter pylori infection, dysplasia and subtotal villous atrophy with a paucity of plasma cells, which was suggestive of common variable immunodeficiency (CVID)-related enteropathy. CVID can present with predominantly autoimmune GI manifestations without any history of recurrent infections. The risk of gastric dysplasia and malignancy is high in CVID and needs close monitoring.