Pediatric neurology · 2026
High-Resolution Vessel Wall Imaging in Pediatric Mycoplasma Pneumoniae-Associated Central Nervous System Vasculitis.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Zhang Mengyao, Li Xinju, Zhang Yanfeng
Аннотация
BACKGROUND: To evaluate the clinical and imaging features, particularly the characteristics of high-resolution vessel wall imaging, in pediatric cases of Mycoplasma pneumoniae-associated central nervous system vasculitis (MP-CNSV).
METHODS: The retrospective study enrolled five pediatric patients diagnosed with MP-CNSV (January 2022 to December 2024). Clinical symptoms, laboratory findings, and imaging results were analyzed.
RESULTS: All five patients exhibited acute neurological deficits, with preceding respiratory infections confirmed as MP infection. Magnetic resonance imaging (MRI) revealed acute ischemic infarctions in all cases, with all lesions localized to anterior circulation vessels. Magnetic resonance angiography and high-resolution vessel wall imaging assessments indicated that 11 out of 55 large and medium vessels were affected, with anterior circulation involvement in all patients. Four out of five cases exhibited multiple segmental foci and three out of five cases displayed long-segment involvement along the internal carotid artery. All patients exhibited grade 3-4 stenosis and concentric enhancement. Clinical follow-up showed remission in all patients. On vessel wall imaging follow-up, one patient showed progression of vascular stenosis at 3 months, which stabilized by 9 months; two patients exhibited reduced vessel wall enhancement and/or stenosis.
CONCLUSIONS: Predominant anterior circulation involvement is a characteristic of childhood MP-CNSV cases in this cohort. A long-segment lesion of the internal carotid artery is also a hallmark of this case series. Moreover, all cases in our study demonstrated a monophasic disease course, which provides valuable insights for the formulation of immunosuppressive treatment strategies.
METHODS: The retrospective study enrolled five pediatric patients diagnosed with MP-CNSV (January 2022 to December 2024). Clinical symptoms, laboratory findings, and imaging results were analyzed.
RESULTS: All five patients exhibited acute neurological deficits, with preceding respiratory infections confirmed as MP infection. Magnetic resonance imaging (MRI) revealed acute ischemic infarctions in all cases, with all lesions localized to anterior circulation vessels. Magnetic resonance angiography and high-resolution vessel wall imaging assessments indicated that 11 out of 55 large and medium vessels were affected, with anterior circulation involvement in all patients. Four out of five cases exhibited multiple segmental foci and three out of five cases displayed long-segment involvement along the internal carotid artery. All patients exhibited grade 3-4 stenosis and concentric enhancement. Clinical follow-up showed remission in all patients. On vessel wall imaging follow-up, one patient showed progression of vascular stenosis at 3 months, which stabilized by 9 months; two patients exhibited reduced vessel wall enhancement and/or stenosis.
CONCLUSIONS: Predominant anterior circulation involvement is a characteristic of childhood MP-CNSV cases in this cohort. A long-segment lesion of the internal carotid artery is also a hallmark of this case series. Moreover, all cases in our study demonstrated a monophasic disease course, which provides valuable insights for the formulation of immunosuppressive treatment strategies.