Australasian journal on ageing · 2025
Hospital Admissions due to Medication-Related Harm in the Last 5 Years of Life: A Cohort Study.
СтатьяНазвание и аннотация: Перевод в очереди
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Mullan Judy R, Moules Stephen, Bonney Andrew
Аннотация
INTRODUCTION: The World Health Organization (WHO) launched the third Global Patient Safety Challenge: Medication without Harm in 2017, aiming to reduce avoidable medication-related harm. Recognising that medication-related harm (MRH) accounts for the highest proportion of preventable harm, this initiative remains active and evolving. This study investigates the demographic and clinical factors associated with medication-related hospital admissions among a cohort of decedents.
METHODS: A retrospective cohort study was conducted using routinely collected non-identifiable linked data from an Australian Local Health District (LHD). The study population comprised residents aged 65 years and over who died in one of the LHD hospitals between 2017 and 2019. Logistic regression models were used to estimate unadjusted and fully adjusted odds ratios for medication-related hospital admissions.
RESULTS: Among the 4353 decedents, 31%-40% experienced at least one hospital admission due to MRH in the last 5 years of life, accounting for 5% of total admissions. Higher rates of medication-related admissions were observed among individuals aged below 70 years, those residing in metropolitan areas and residential aged care facility residents. Comorbidities such as renal failure, heart failure, transient ischaemic attack, hypertension, diabetes and chronic obstructive pulmonary disease (COPD) were significant predictors of medication-related admissions.
CONCLUSIONS: In our cohort of decedents, one-third had at least one hospitalisation due to MRH in their final 5 years. Higher risk was associated with being under 70 years of age, living in metropolitan or aged care settings and having multiple or specific chronic conditions. These results highlight the need for targeted interventions for high-risk individuals nearing the end of life.
METHODS: A retrospective cohort study was conducted using routinely collected non-identifiable linked data from an Australian Local Health District (LHD). The study population comprised residents aged 65 years and over who died in one of the LHD hospitals between 2017 and 2019. Logistic regression models were used to estimate unadjusted and fully adjusted odds ratios for medication-related hospital admissions.
RESULTS: Among the 4353 decedents, 31%-40% experienced at least one hospital admission due to MRH in the last 5 years of life, accounting for 5% of total admissions. Higher rates of medication-related admissions were observed among individuals aged below 70 years, those residing in metropolitan areas and residential aged care facility residents. Comorbidities such as renal failure, heart failure, transient ischaemic attack, hypertension, diabetes and chronic obstructive pulmonary disease (COPD) were significant predictors of medication-related admissions.
CONCLUSIONS: In our cohort of decedents, one-third had at least one hospitalisation due to MRH in their final 5 years. Higher risk was associated with being under 70 years of age, living in metropolitan or aged care settings and having multiple or specific chronic conditions. These results highlight the need for targeted interventions for high-risk individuals nearing the end of life.