Estimating Multimodal Structural Brain Variability in Schizophrenia Spectrum Disorders: A Worldwide ENIGMA Study.
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Omlor Wolfgang, Rabe Finn, Fuchs Simon, Surbeck Werner, Cecere Giacomo, Huang Gao-Yang, Homan Stephanie, Kallen Nils, Georgiadis Foivos, Spiller Tobias, Seifritz Erich, Weickert Thomas, Bruggemann Jason, Weickert Cynthia, Potkin Steven, Hashimoto Ryota, Sim Kang, Rootes-Murdy Kelly, Quide Yann, Houenou Josselin, Banaj Nerisa, Vecchio Daniela, Piras Fabrizio, Piras Federica, Spalletta Gianfranco, Salvador Raymond, Karuk Andriana, Pomarol-Clotet Edith, Rodrigue Amanda, Pearlson Godfrey, Glahn David, Tomecek David, Spaniel Filip, Skoch Antonin, Kirschner Matthias, Kaiser Stefan, Kochunov Peter, Fan Feng-Mei, Andreassen Ole A, Westlye Lars T, Berthet Pierre, Calhoun Vince D, Howells Fleur, Uhlmann Anne, Scheffler Freda, Stein Dan, Iasevoli Felice, Cairns Murray J, Carr Vaughan J, Catts Stanley V, Di Biase Maria A, Jablensky Assen, Green Melissa J, Henskens Frans A, Klauser Paul, Loughland Carmel, Michie Patricia T, Mowry Bryan, Pantelis Christos, Rasser Paul E, Schall Ulrich, Scott Rodney, Zalesky Andrew, de Bartolomeis Andrea, Barone Annarita, Ciccarelli Mariateresa, Brunetti Arturo, Cocozza Sirio, Pontillo Giuseppe, Tranfa Mario, Di Giorgio Annabella, Thomopoulos Sophia I, Jahanshad Neda, Thompson Paul M, van Erp Theo, Turner Jessica, Homan Philipp
Аннотация
METHODS: The authors used the ENIGMA dataset of MRI-based brain measures from 22 international sites with up to 6,037 individuals for a given brain measure. Variability and mean values of cortical thickness, cortical surface area, cortical folding index, subcortical volume, and fractional anisotropy were examined in individuals with schizophrenia and healthy control subjects.
RESULTS: Individuals with schizophrenia showed greater variability in cortical thickness, cortical surface area, subcortical volume, and fractional anisotropy within the frontotemporal and subcortical network. This increased structural variability was mainly associated with psychopathological symptom domains, and the schizophrenia group frequently displayed lower mean values in the respective structural measures. Unexpectedly, folding patterns were more uniform in individuals with schizophrenia, particularly in the right caudal anterior cingulate region. The mean folding values of the right caudal anterior cingulate region did not differ between the schizophrenia and healthy control groups, and folding patterns in this region were not associated with disease-related parameters.
CONCLUSIONS: In patients with schizophrenia, uniform folding patterns in the right caudal anterior cingulate region contrasted with the multimodal variability in the frontotemporal and subcortical network. While variability in the frontotemporal and subcortical network was associated with disease-related diversity, uniform folding may indicate a less flexible interplay between genetic and environmental factors during neurodevelopment.