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DOI 10.1038/s41467-026-74153-2

Медицинская библиотека · Nature communications · 2026

Regional, functional and transcriptomic decoding of multidimensional brain structure alterations in obsessive-compulsive disorder.

Cardoso Saraiva Leonardo, Sato João R, Sebenius Isaac, Dzinalija Nadza, Del Río-Torné Carla, Godinho Fábio, Lopes Antonio C, Fernandez Thomas V, Lima Monicke O, Ramos Vanessa R, Iglesio Ricardo, Abe Yoshinari, Alonso Pino, Ameis Stephanie H, Anticevic Alan, Araújo Ana, Arnold Paul D, Balachander Srinivas, Banaj Nerisa, Batistuzzo Marcelo C, Benedetti Francesco, Bollettini Irene, Bravi Beatrice, Brennan Brian, Buitelaar Jan, Castelo-Branco Miguel, Choi Sunah, Costa Ana D, Dallaspezia Sara, Denys Damiaan, Duarte Isabel C, Echevarria Marco A N, Eng Goi Khia, Fernandes Afonso, Feusner Jamie D, Figee Martijn, Fitzsimmons Sophie M D D, Fontenelle Leonardo F, Grazioplene Rachael, Ha Minji, Hinojosa Alejandro, Hoexter Marcelo Q, Huijser Chaim, Hu Hao, James Anthony, Kim Minah, Kwon Jun Soo, Lazaro Luisa, Lochner Christine, Machado-Sousa Mafalda, van Marle Hein, Martínez-Zalacaín Ignacio, Mataix-Cols David, Menchón José M, Minuzzi Luciano, Morgado Pedro, Muñoz-Moreno Emma, Nakao Tomohiro, Narayanaswamy Janardhanan C, Nurmi Erika L, O'Neill Joseph, Park Inkyung, Phillips Mary L, Piacentini John C, Picó-Pérez Maria, Piras Fabrizio, Piras Federica, Postma Tjardo S, Li Chiang-Shan R, Reddy Janardhan Y C, van Rooij Daan, Sakai Yuki, de Salles Andrade Juliana B, Scheffler Freda, Shivakumar Venkataram, Soreni Noam, Stern Emily R, van der Straten Anouk, Thomopoulos Sophia I, Tomiyama Hirofumi, Tovar-Moll Fernanda, Vecchio Daniela, Veltman Dick J, Venkatasubramanian Ganesan, Vriend Chris, Wang Zhen, van der Werf Ysbrand D, van Wingen Guido, Zhao Qing, ENIGMA-OCD Working Group, Charney Alexander W, Cho Youngsun T, Shavitt Roseli G, Pushkarskaya Helen, Soriano-Mas Carles, Romero-Garcia Rafael, Thompson Paul M, Stein Dan J, van den Heuvel Odile A, Winkler Anderson M, Miguel Filho Euripedes C, Pittenger Christopher, Cappi Carolina

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Аннотация

Studies of brain morphology in mental illness often focus on a few neuroimaging phenotypes. Here we present a comprehensive morphological characterization in obsessive-compulsive disorder (OCD) in a large sample (2255 OCD, 2264 controls) using nine cortical and four subcortical phenotypes, including several not previously examined in OCD, among them a subcortical structural similarity network phenotype developed here. Spatially distinct regional alterations emerged across structural phenotypes: cortical curvature alterations in default mode and frontoparietal networks, increased structural similarity network node degree in sensorimotor regions, widespread volume reductions associated with medication use, and localized subcortical shape alterations. In brain-behavior predictive models, curvature phenotypes showed the strongest associations with clinical features. Cortical alterations, especially in structural similarity networks, were associated with specific gene expression patterns, implicating dysregulation of excitatory neurons. RNA-sequencing data from tissue collected during functional neurosurgery revealed that genes downregulated in the dorsolateral prefrontal cortex in OCD contributed to the gene expression patterns linked to cortical alterations. Previously reported differentially expressed genes from postmortem brain studies of OCD also contributed. These findings support the importance of a comprehensive approach to characterizing brain morphology and suggest that cortical curvature and structural similarity alterations reflect key pathophysiological processes in OCD.

Для цитирования: Cardoso Saraiva Leonardo, Sato João R, Sebenius Isaac, Dzinalija Nadza, Del Río-Torné Carla, Godinho Fábio, Lopes Antonio C, Fernandez Thomas V, Lima Monicke O, Ramos Vanessa R, Iglesio Ricardo, Abe Yoshinari, Alonso Pino, Ameis Stephanie H, Anticevic Alan, Araújo Ana, Arnold Paul D, Balachander Srinivas, Banaj Nerisa, Batistuzzo Marcelo C, Benedetti Francesco, Bollettini Irene, Bravi Beatrice, Brennan Brian, Buitelaar Jan, Castelo-Branco Miguel, Choi Sunah, Costa Ana D, Dallaspezia Sara, Denys Damiaan, Duarte Isabel C, Echevarria Marco A N, Eng Goi Khia, Fernandes Afonso, Feusner Jamie D, Figee Martijn, Fitzsimmons Sophie M D D, Fontenelle Leonardo F, Grazioplene Rachael, Ha Minji, Hinojosa Alejandro, Hoexter Marcelo Q, Huijser Chaim, Hu Hao, James Anthony, Kim Minah, Kwon Jun Soo, Lazaro Luisa, Lochner Christine, Machado-Sousa Mafalda, van Marle Hein, Martínez-Zalacaín Ignacio, Mataix-Cols David, Menchón José M, Minuzzi Luciano, Morgado Pedro, Muñoz-Moreno Emma, Nakao Tomohiro, Narayanaswamy Janardhanan C, Nurmi Erika L, O'Neill Joseph, Park Inkyung, Phillips Mary L, Piacentini John C, Picó-Pérez Maria, Piras Fabrizio, Piras Federica, Postma Tjardo S, Li Chiang-Shan R, Reddy Janardhan Y C, van Rooij Daan, Sakai Yuki, de Salles Andrade Juliana B, Scheffler Freda, Shivakumar Venkataram, Soreni Noam, Stern Emily R, van der Straten Anouk, Thomopoulos Sophia I, Tomiyama Hirofumi, Tovar-Moll Fernanda, Vecchio Daniela, Veltman Dick J, Venkatasubramanian Ganesan, Vriend Chris, Wang Zhen, van der Werf Ysbrand D, van Wingen Guido, Zhao Qing, ENIGMA-OCD Working Group, Charney Alexander W, Cho Youngsun T, Shavitt Roseli G, Pushkarskaya Helen, Soriano-Mas Carles, Romero-Garcia Rafael, Thompson Paul M, Stein Dan J, van den Heuvel Odile A, Winkler Anderson M, Miguel Filho Euripedes C, Pittenger Christopher, Cappi Carolina. Regional, functional and transcriptomic decoding of multidimensional brain structure alterations in obsessive-compulsive disorder.. Nature communications. 2026. DOI: 10.1038/s41467-026-74153-2.

Предметные рубрики MeSH

Obsessive-Compulsive DisorderHumansBrainTranscriptomeFemaleMaleMagnetic Resonance ImagingAdultPhenotype
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