Nature · 2026

Distributed control circuits across a brain-and-cord connectome.

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Bates Alexander S, Phelps Jasper S, Kim Minsu, Yang Helen H, Matsliah Arie, Ajabi Zaki, Perlman Eric, Delgado Kevin M, Osman Mohammed Abdal Monium, Salmon Christopher K, Gager Jay, Silverman Benjamin, Renauld Sophia, Salman Farzaan, Patel Janki, Collie Matthew F, Fan Jingxuan, Pacheco Diego A, Zhao Yunzhi, Zhang Wenyi, Serratosa Capdevila Laia, Roberts Ruairí J V, Munnelly Eva J, Griggs Nina, Langley Helen, Moya-Llamas Borja, Zhang Zuoyu, Maloney Ryan T, Yu Szi-Chieh, Sterling Amy R, Sorek Marissa, Kruk Krzysztof, Serafetinidis Nikitas, Dhawan Serene, Klemm Finja, Brooks Paul, Lesser Ellen, Jones Jessica M, Pierce-Lundgren Sara E, Lee Su-Yee, Luo Yichen, Cook Andrew P, McKim Theresa H, Giakoumas Dimitrios Stasi, Gorko Benjamin, Ellis-Joyce Justin, Zhang Jiayi, Kophs Emily C, Falt Tjalda, Negron-Morales Alexa M, Burke Austin, Hebditch James, Willie Kyle P, Willie Ryan, Popovych Sergiy, Kemnitz Nico, Ih Dodam, Lee Kisuk, Lu Ran, Halageri Akhilesh, Bae J Alexander, Jourdan Ben, Schwartzman Gregory, Demarest Damian D, Behnke Emily, Bland Doug, Kristiansen Anne, Skelton Jaime, Stocks Tom, Garner Dustin, Hernandez Anthony, Kumar Sandeep, BANC-FlyWire Consortium, Daly Kevin C, Dorkenwald Sven, Collman Forrest, Suver Marie P, Fenk Lisa M, Pankratz Michael J, Yao Zepeng, Wang Fei, Huston Stephen J, Stürner Tomke, Jefferis Gregory S X E, Eichler Katharina, Seeds Andrew M, Hampel Stefanie, Agrawal Sweta, Okubo Tatsuo S, Zandawala Meet, Macrina Thomas, Adjavon Diane-Yayra, Funke Jan, Tuthill John C, Azevedo Anthony, Seung H Sebastian, de Bivort Benjamin L, Murthy Mala, Drugowitsch Jan, Wilson Rachel I, Lee Wei-Chung Allen

Аннотация

Just as genomes revolutionized molecular genetics, connectomes (maps of neurons and synapses) are transforming neuroscience. To date, the only organisms with complete connectomes are worms1-3, sea squirts4 and comb jellies5 (103-104 synapses). By contrast, the fruit fly is more complex (108 synaptic connections), with a brain that supports learning and spatial memory6,7 and an intricate ventral nerve cord analogous to the vertebrate spinal cord8-12. Here we report a densely reconstructed adult fly connectome that unites the brain and ventral nerve cord, and we leverage this resource to investigate principles of neural control. We show that effector neurons (motor neurons, endocrine cells and efferent neurons targeting the viscera) are primarily influenced by sensory neurons in the same body part, forming local feedback loops. These local loops are linked by long-range circuits that involve ascending and descending neurons organized into behaviour-centric modules. Single ascending and descending neurons are often positioned to influence the voluntary movements of multiple body parts, together with the endocrine cells or visceral organs that support those movements. Brain regions involved in learning and navigation supervise these circuits. These results reveal an architecture that is distributed, parallelized and embodied, reminiscent of distributed control architectures in engineered systems13,14.

Предметные рубрики MeSH

Animals Female Male Brain Connectome Drosophila melanogaster Endocrine Cells Motor Neurons Neural Pathways Neurons Neurons, Efferent Sensory Receptor Cells Synapses

Distributed control circuits across a brain-and-cord connectome.

Ошибки и ограничения

Аннотация

Предметные рубрики MeSH