Molecular biology reports · 2025
A novel HPS3 pathogenic nonsense variant associated with Hermansky-Pudlak syndrome type 3 and a platelet dysfunction.
СтатьяКлинический случайНазвание и аннотация: Перевод в очереди
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Chouman Chahnaz, Salhab Suzana, Martella Salvatore, Mousawi Zahraa, Assi Alexandre, Chebly Alain, El Shamieh Said
Аннотация
BACKGROUND: Hermansky-Pudlak Syndrome (HPS) is a rare autosomal recessive syndromic type of albinism. It is characterized by oculocutaneous hypopigmentation, platelet dysfunction, and variable systemic involvement depending on the specific subtype. To date, eleven distinct HPS types have been identified, with HPS3 being among the milder forms.
METHODS AND RESULTS: Clinical and ophthalmic examinations, followed by whole exome sequencing (WES), Sanger sequencing, and segregation analysis, were performed. Here, we report a case of a 26-year-old Lebanese male patient born to consanguineous parents who presented with oculocutaneous albinism without a history of bleeding or other systemic involvement. WES identified a novel homozygous nonsense variant in the HPS3 gene (NM_032383.5): c.998T > A; p.(Leu333Ter) that co-segregated with the phenotype. The platelet function analysis (PFA-100) revealed a prolonged collagen/epinephrine closure time, accompanied by a normal collagen/ADP response.
CONCLUSIONS: We report one of the very few HPS3 cases in the Middle East and North Africa region (MENA) and the Arab regions, caused by a novel homozygous nonsense variant associated with platelet dysfunction. In contrast to the founder mutations described in Puerto Rican and Ashkenazi Jewish populations, HPS3 cases in this region appear to result from distinct mutational events, indicating the absence of a common ancestral origin.
METHODS AND RESULTS: Clinical and ophthalmic examinations, followed by whole exome sequencing (WES), Sanger sequencing, and segregation analysis, were performed. Here, we report a case of a 26-year-old Lebanese male patient born to consanguineous parents who presented with oculocutaneous albinism without a history of bleeding or other systemic involvement. WES identified a novel homozygous nonsense variant in the HPS3 gene (NM_032383.5): c.998T > A; p.(Leu333Ter) that co-segregated with the phenotype. The platelet function analysis (PFA-100) revealed a prolonged collagen/epinephrine closure time, accompanied by a normal collagen/ADP response.
CONCLUSIONS: We report one of the very few HPS3 cases in the Middle East and North Africa region (MENA) and the Arab regions, caused by a novel homozygous nonsense variant associated with platelet dysfunction. In contrast to the founder mutations described in Puerto Rican and Ashkenazi Jewish populations, HPS3 cases in this region appear to result from distinct mutational events, indicating the absence of a common ancestral origin.