Psychological and psychopathological factors in alopecia areata.

INTRODUCTION

Natural latex allergy poses significant risks in medicine due to widespread use of the material and potential for severe reactions.

AIM: To examine latex allergy causes, clinical manifestations, and contemporary diagnostic approaches through systematic literature review.

METHODS

Systematic analysis of 67 publications published between 2019 and 2024, conducted from August to December 2024, using multiple databases, defined inclusion/exclusion criteria, and comparative content analysis.

RESULTS

Fresh latex comprises 60% water, 35% polyisoprene, and 5% proteins/lipids, with Hev b proteins being highly sensitising. Medical personnel demonstrate 5-17% allergy prevalence; industrial workers show up to 12% sensitisation. Key risk factors include atopy, tropical fruit cross-reactivity, and multiple childhood surgeries. Skin tests, specific IgE detection, and provocation tests demonstrate high diagnostic efficacy.

CONCLUSIONS

Unified allergenicity assessment standards and enhanced regulatory control are essential. Transitioning to synthetic alternatives and improving early diagnostic protocols can reduce complications and enhance safety.