Journal of cosmetic dermatology · 2026
Oral JAK Inhibitors as a Promising Therapeutic Strategy for Refractory Rosacea: A Systematic Review and Meta-Analysis.
Систематический обзорСтатьяМетаанализНазвание и аннотация: Перевод в очереди
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Peng Yu, Sun Mingzi, Chen Jiayu, Huang Xubo, Zhang Fengchuan
Аннотация
BACKGROUND: Rosacea is a chronic inflammatory dermatosis. While standard therapies exist, managing refractory subtypes remains a therapeutic challenge. Oral Janus kinase (JAK) inhibitors have emerged as potential alternatives, but systematic evidence is lacking.
AIMS: To evaluate the efficacy and safety of oral JAK inhibitors for rosacea through a systematic review and meta-analysis.
METHODS: A comprehensive search was conducted in five databases from inception to December 1, 2025. The primary outcome was the pooled clinical response rate. Secondary outcomes included the Investigator's Global Assessment (IGA), Clinician's Erythema Assessment (CEA), and Dermatology Life Quality Index (DLQI).
RESULTS: Eleven studies involving 57 patients were included. The overall pooled response rate was 89.9% (95% CI: 74.4%-99.4%), with low heterogeneity (I2 = 16.3%). Regarding secondary outcomes, 67.8% of patients achieved an IGA score of ≤ 1, and 74.6% achieved a CEA reduction of ≥ 2 points. DLQI score also decreased from 17.30 ± 3.80 to 10.00 ± 3.43. Adverse events were reported in 10.5% of patients.
CONCLUSIONS: Oral JAK inhibitors show promising potential as a therapeutic option for refractory rosacea. However, given the small sample size and single-arm design, these findings are exploratory. Large-scale randomized controlled trials are urgently needed to validate these findings and guide stratified treatment.
AIMS: To evaluate the efficacy and safety of oral JAK inhibitors for rosacea through a systematic review and meta-analysis.
METHODS: A comprehensive search was conducted in five databases from inception to December 1, 2025. The primary outcome was the pooled clinical response rate. Secondary outcomes included the Investigator's Global Assessment (IGA), Clinician's Erythema Assessment (CEA), and Dermatology Life Quality Index (DLQI).
RESULTS: Eleven studies involving 57 patients were included. The overall pooled response rate was 89.9% (95% CI: 74.4%-99.4%), with low heterogeneity (I2 = 16.3%). Regarding secondary outcomes, 67.8% of patients achieved an IGA score of ≤ 1, and 74.6% achieved a CEA reduction of ≥ 2 points. DLQI score also decreased from 17.30 ± 3.80 to 10.00 ± 3.43. Adverse events were reported in 10.5% of patients.
CONCLUSIONS: Oral JAK inhibitors show promising potential as a therapeutic option for refractory rosacea. However, given the small sample size and single-arm design, these findings are exploratory. Large-scale randomized controlled trials are urgently needed to validate these findings and guide stratified treatment.