Journal of pregnancy · 2016
Pregnancy and Birth Outcomes among Women with Idiopathic Thrombocytopenic Purpura.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Wyszynski Diego F, Carman Wendy J, Cantor Alan B, Graham John M, Kunz Liza H, Slavotinek Anne M, Kirby Russell S, Seeger John
Аннотация
OBJECTIVE: To examine pregnancy and birth outcomes among women with idiopathic thrombocytopenic purpura (ITP) or chronic ITP (cITP) diagnosed before or during pregnancy.
METHODS: A linkage of mothers and babies within a large U.S. health insurance database that combines enrollment data, pharmacy claims, and medical claims was carried out to identify pregnancies in women with ITP or cITP. Outcomes included preterm birth, elective and spontaneous loss, and major congenital anomalies.
RESULTS: Results suggest that women diagnosed with ITP or cITP prior to their estimated date of conception may be at higher risk for stillbirth, fetal loss, and premature delivery. Among 446 pregnancies in women with ITP, 346 resulted in live births. Women with cITP experienced more adverse outcomes than those with a pregnancy-related diagnosis of ITP. Although 7.8% of all live births had major congenital anomalies, the majority were isolated heart defects. Among deliveries in women with cITP, 15.2% of live births were preterm.
CONCLUSIONS: The results of this study provide further evidence that cause and duration of maternal ITP are important determinants of the outcomes of pregnancy.
METHODS: A linkage of mothers and babies within a large U.S. health insurance database that combines enrollment data, pharmacy claims, and medical claims was carried out to identify pregnancies in women with ITP or cITP. Outcomes included preterm birth, elective and spontaneous loss, and major congenital anomalies.
RESULTS: Results suggest that women diagnosed with ITP or cITP prior to their estimated date of conception may be at higher risk for stillbirth, fetal loss, and premature delivery. Among 446 pregnancies in women with ITP, 346 resulted in live births. Women with cITP experienced more adverse outcomes than those with a pregnancy-related diagnosis of ITP. Although 7.8% of all live births had major congenital anomalies, the majority were isolated heart defects. Among deliveries in women with cITP, 15.2% of live births were preterm.
CONCLUSIONS: The results of this study provide further evidence that cause and duration of maternal ITP are important determinants of the outcomes of pregnancy.
Предметные рубрики MeSH
AdolescentAdultChronic DiseaseCohort StudiesCongenital AbnormalitiesDatabases, FactualFemaleFetal DeathHumansInfant, NewbornLive BirthPregnancyPregnancy Complications, HematologicPregnancy OutcomePremature BirthPurpura, Thrombocytopenic, IdiopathicRetrospective StudiesStillbirthUnited StatesYoung Adult