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New Avenues and Major Achievements in Phytocompounds Research for Glioblastoma Therapy.

Phytocompounds have been evaluated for their anti-glioblastoma actions for decades, with promising results from preclinical studies but only limited translation into clinics. Indeed, by targeting multiple signaling pathways deregulated in cancer, they often show high efficacy in the in vitro studies, but their poor bioavailability, low tumor accumulation, and rapid clearance compromise their efficacy in vivo. Here, we present the new avenues in phytocompound research for the improvement of glioblastoma therapy, including the ways to enhance the response to temozolomide using phytochemicals, th

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… Creating mannosylated liposomes to deliver chlorogenic acid to TAMs was yet another proposal [ 70 ]. … Besides cannabinoids, chlorogenic acid also reached the clinical trial phase. …

Gastrointestinal Cancer Therapeutics via Triggering Unfolded Protein Response and Endoplasmic Reticulum Stress by 2-Arylbenzofuran.

Gastrointestinal cancers are a major global health challenge, with high mortality rates. This study investigated the anti-cancer activities of 30 monomers extracted from Morus alba L. (mulberry) against gastrointestinal cancers. Toxicological assessments revealed that most of the compounds, particularly immunotoxicity, exhibit some level of toxicity, but it is generally not life-threatening under normal conditions. Among these components, Sanggenol L, Sanggenon C, Kuwanon H, 3'-Geranyl-3-prenyl-5,7,2',4'-tetrahydroxyflavone, Morusinol, Mulberrin, Moracin P, Kuwanon E, and Kuwanon A demonstrate

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… Chlorogenic acid induces reactive oxygen species generation and inhibits the viability of human colon cancer cells. Anti-Cancer Drugs. 2017;28:59–65. doi: 10.1097/CAD.0000000000000430. 68. Thurow T. Effect of Chlorogenic Acid and Neochlorogenic Acid on Human Colon Cancer Cells. Discov. Stud. J. … Polyphenol chlorogenic acid, antioxidant profile, and breast cancer; pp. 311–321. 70. Zeng A., Liang X., Zhu S., Liu C., Wang S., Zhang Q., Zhao J., Song L. Chlorogenic acid induces apoptosis, inhibits metastasis and improves antitumor immunity in breast cancer via the NFκB signaling pathway. …

Zhenqi Fuzheng Granule targets the SCFAs-GPR109A axis to enhance PD-1 antibody efficacy via immunometabolic remodeling in colorectal cancer.

BACKGROUND: Immune checkpoint inhibitors (ICIs), particularly PD-1 antibodies, represent a breakthrough in colorectal cancer (CRC) treatment … droside (0.11 mg/g), Astragaloside IV (0.07 mg/g), Calycosin (0.03 mg/g), Formononetin (6.7 μg /g), Chlorogenic acid (1.4 μg/g), Apigenin (0.5 μg/g). In vivo studies, both ZQFZ and PD-1 antibody inhibited tumour growth, with the combination treatment exerting the most pronounced antitumour effects. ZQFZ reshaped the gut microbiota, increased the levels of short-ch …

Полифенолы и нейродегенеративные заболевания: понимание знаний, механистические свидетельства и новые виды применения в области питания.

Полифенолы представляют собой разнообразную группу биоактивных веществ растительного происхождения, которые были исследованы в качестве многоцелевых возможностей для потенциальной профилактики и лечения нейродегенеративных заболеваний (НДИ). Мы провели комплексный библиометрический и механистический обзор, охватывающий 12 классов полифенола и семь основных НИЗ, с использованием записей из PubMed, Embase, Cochrane Bibrary и Web of Science (1940-2024). Для картирования исследовательских ландшафтов и новых тем использовались ключевые слова, анализы по группам и модели BERTopic. Механистические до

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… They are broadly classified into flavonoids (including flavones, isoflavones, flavonols, flavanols, flavanones, anthocyanidins), phenolic acids (e.g., caffeic acid, chlorogenic acid), stilbenes (e.g., resveratrol), lignans, tannins [ 19 ], and others (e.g., coumarins, anthraquinones). … Effects of chlorogenic acid against aluminium neurotoxicity in ICR mice through chelation and antioxidant actions. J. Funct. Foods. 2018;40:365–376. doi: 10.1016/j.jff.2017.11.013. 16. Nguyen-Thi P.-T., Vo T.K., Pham T.H.T., Nguyen T.T., Vo G.V. …

Adjuvant Properties of Caffeic Acid in Cancer Treatment.

Caffeic acid (CA) is a polyphenol belonging to the phenylpropanoid family, commonly found in plants and vegetables. It was first identified by Hlasiwetz in 1867 as a breakdown product of caffetannic acid. CA is biosynthesized from the amino acids tyrosine or phenylalanine through specific enzyme-catalyzed reactions. Extensive research since its discovery has revealed various health benefits associated with CA, including its antioxidant, anti-inflammatory, and anticancer properties. These effects are attributed to its ability to modulate several pathways, such as inhibiting NFkB, STAT3, and ERK

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… Identification, quantitative determination, and antioxidative activities of chlorogenic acid isomers in prune (Prunus domestica L.) J. Agric. Food Chem. 2000;48:5512–5516. doi: 10.1021/jf000422s. 26. Bianco A., Buiarelli F., Cartoni G., Coccioli F., Jasionowska R., Margherita P. … Quantification of chlorogenic acid, rosmarinic acid, and caffeic acid contents in selected Thai medicinal plants using RP-HPLC-DAD. Braz. J. Pharm. Sci. 2020;56:e17547. doi: 10.1590/s2175-97902019000317547. 36. …

Precision medicine for mood disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs.

Mood disorders (depression, bipolar disorders) are prevalent and disabling. They are also highly co-morbid with other psychiatric disorders. … dolol, ciprofibrate, pioglitazone and adiphenine, as well as the natural compounds asiaticoside and chlorogenic acid. The last 3 had also been identified by our previous suicidality studies. Finally, we provide an example of how a report to doctors would look for a patient with depression, based on the panel of top biomarkers (12 for depression and bipolar, one fo …

Targeting Macrophage Migration Inhibitory Factor in Acute Pancreatitis and Pancreatic Cancer.

Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine implicated in the pathogenesis of inflammation and cancer. It is produced by various cells and circulating MIF has been identified as a biomarker for a range of diseases. Extracellular MIF mainly binds to the cluster of differentiation 74 (CD74)/CD44 to activate downstream signaling pathways. These in turn activate immune responses, enhance inflammation and can promote cancer cell proliferation and invasion. Extracellular MIF also binds to the C-X-C chemokine receptors cooperating with or without CD74 to activate chemokine

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… acid (20 or 40 mg/kg; i.p., 1 h before AP induction) | Chlorogenic acid suppressed AP-induced increase of MIF levels in serum and pancreatic tissue | Ohkawara et al. (2017) l -arginine (2 × 4 g/kg; i.p., 1 h interval) | Mif −/- and WT C57BL/6 mice | ISO-1 (3.5 mg/kg; i.p. 30 min before first l -arginine … Protective effect of chlorogenic acid on the inflammatory damage of pancreas and lung in mice with l-arginine-induced pancreatitis. Life Sci. 190, 91–96. 10.1016/j.lfs.2017.09.015 Oliveira C. S., De Bock C. E., Molloy T. J., Sadeqzadeh E., Geng X. Y., Hersey P., et al. (2014). …

Резюме ежегодного совещания Университета медицины и фармацевтики: 4th - 8th декабрь 2023, Клюй-Напока

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Natural Compounds with Potential to Modulate Cancer Therapies and Self-Reactive Immune Cells.

Cancer-related deaths are approaching 10 million each year. Survival statistics for some cancers, such as ovarian cancer, have remained unchanged for decades, with women diagnosed at stage III or IV having over 80% chance of a lethal cancer recurrence after standard first-line treatment (reductive surgery and chemotherapy). New treatments and adjunct therapies are needed. In ovarian cancer, as in other cancers, the immune response, particularly cytotoxic (CD8+) T cells are correlated with a decreased risk of recurrence. As well as completely new antigen targets resulting from DNA mutations (ne

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… acid Biochanin A | [ 162 ] Muntries | Kunzea pomifera | Antioxidant and induces apoptosis and inhibits proliferation in cancer cell lines | Delphinidin 3-glucoside cyanidin 3-glucoside | [ 165 , 166 ] Tasmanian pepper berry | Tasmannia lanceolata | Antioxidant | Cyanidin 3-rutinoside Cyanidin 3-glucoside … Rutin Chlorogenic acid Caffeic acid Quercetin | [ 166 , 167 ] Tasmanian pepper leaf | Tasmannia lanceolata | Antioxidant | Chlorogenic acid Quercetin p-Coumaric acid Cyanidin 3-glucoside | [ 167 ] Anise myrtle | Syzygium anisatum | Antioxidant and anti-inflammatory | Chlorogenic acid Myricetin Quercetin …

Dietary Polyphenols and Their Biological Significance

Dietary polyphenols represent a wide variety of compounds that occur in fruits, vegetables, wine, tea, extra virgin olive oil, chocolate and other cocoa products. They are mostly derivatives and/or isomers of flavones, isoflavones, flavonols, catechins and phenolic acids, and possess diverse biological properties such as antioxidant, antiapoptosis, anti-aging, anticarcinogen, anti-inflammation, anti-atherosclerosis, cardiovascular protection, improvement of the endothelial function, as well as inhibition of angiogenesis and cell proliferation activity. Most of these biological actions have bee

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… The major hydroxycinnamic acid is caffeic acid, which occurs in foods mainly as an ester with quinic acid called chlorogenic acid (5-caffeoylquinic acid). … Chlorogenic acid and caffeic acid are antioxidants in vitro and they might inhibit the formation of mutagenic and carcinogenic N -nitroso compounds for the inhibitory effect on the N -nitrosation reaction in vitro . …

A Review on the Molecular Mechanisms of Action of Natural Products in Preventing Bone Diseases.

The drugs used for treating bone diseases (BDs), at present, elicit hazardous side effects that include certain types of cancers and strokes, hence the ongoing quest for the discovery of alternatives with little or no side effects. Natural products (NPs), mainly of plant origin, have shown compelling promise in the treatments of BDs, with little or no side effects. However, the paucity in knowledge of the mechanisms behind their activities on bone remodeling has remained a hindrance to NPs' adoption. This review discusses the pathological development of some BDs, the NP-targeted components, an

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… Based on these findings, natural products such as gastrodin, icariin, and chlorogenic acid with antioxidant ability via the binding to and translocation of Nrf to the nucleus to upregulate the expression of antioxidant molecules will alleviate ROS-mediated bone loss. … Chlorogenic Acid Promotes the Nrf2/HO-1 Anti-Oxidative Pathway by Activating P21 Waf1/Cip1 to Resist Dexamethasone-Induced Apoptosis in Osteoblastic Cells Free Radic. Biol. Med. 2019 137 1 12 10.1016/j.freeradbiomed.2019.04.014 31004750 130. Yang J. Wu Q. Lv J. …

Platycodon grandiflorum, as a medicinal and food homologous plant: a comprehensive review of anti-tumor components, mechanisms, modern applications, and preventive healthcare.

Platycodon grandiflorum (Jacq.) A. D C. (P. grandiflorum), as a medicinal and edible plant, is widely distributed in China. In terms of Chinese medical theories, Traditional Chinese Medicine (TCM) believes that the root of P. grandiflorum has the functions of relieving sore throat, eliminating phlegm, and draining pus, and is widely used in lung diseases and respiratory system disorders. Modern pharmacological studies have shown that Platycodon grandiflorum saponin, flavonoids, polysaccharides, and phenolic acids are the main active components of P. grandiflorum, which have significant antitus

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… acid. … acid 500 mg/100 g Jinyinhua Jiegeng Fig extract lozenge | Fig (irradiated), Platycodon grandiflorum ( P. grandiflorum ), Honeysuckle extract (Jinyinhua). | G20141269 | Crude polysaccharide 4.34 g/100 g; chlorogenic acid 0.34 g/100 g Jiegeng Dihuang lozenge | Scrophularia ningpoensis (Xuansheng), Rehmannia …

Antioxidant Intake and Antitumor Therapy: Toward Nutritional Recommendations for Optimal Results.

The role of the induction of oxidative stress as the mechanism of action of many antitumor drugs is acquiring an increasing interest. In such cases, the antitumor therapy success may be conditioned by the antioxidants present in our own body, which can be synthesized de novo (endogenous) or incorporated through the diet and nutritional supplements (exogenous). In this paper, we have reviewed different aspects of antioxidants, including their classification, natural sources, importance in diet, consumption of nutritional supplements, and the impact of antioxidants on health. Moreover, we have f

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… acids | Coffee Ferulic acid | Cereals, seeds, citrus fruits, and some vegetables Tea and coffee are very important sources of antioxidants for humans. … In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid. International Journal of Pharmaceutics. 2011;403(1-2):136–138. doi: 10.1016/j.ijpharm.2010.09.035. 53. Zhao Z., Moghadasian M. H. …

ACY‑1215, a HDAC6 inhibitor, decreases the dexamethasone‑induced suppression of osteogenesis in MC3T3‑E1 cells.

Glucocorticoid‑induced osteoporosis is the commonest form of drug‑induced osteoporosis. Histone deacetylase 6 (HDAC6) is involved in the differentiation from mesenchymal stem cells to osteoblasts. However, the role of ricolinostat (ACY‑1215, HDAC6 inhibitor) in the dexamethasone (Dex)‑induced proliferation and differentiation of preosteoblasts remains to be elucidated. The protein expression and mRNA expression levels of HDAC6, osteopontin (OPN), runt‑related transcription factor 2 (Runx2), osterix (Osx), collagen I (COL1A1) and glucocorticoid receptor (GR) in MC3T3‑E1 cells were analyzed by w

(Поли) фенолы и множественный склероз: результаты межсекционного исследования наблюдений.

(Поли) фенолы представляют собой широкий и разнородный класс веществ с рядом потенциальных преимуществ для здоровья. Их роль в нейрозащите и когниции по-прежнему вызывает сомнения. Цель этого исследования заключается в изучении возможной взаимосвязи между общим и индивидуальным (поли)поглощением фенола, основными источниками питания и остротой множественного склероза (МС) в группе пациентов, страдающих НР. Были собраны демографические данные, данные о физической активности участников, данные о курении и рационе питания наряду с клиническими параметрами, включая Расширенный цикл оценки инвалидн

Googling the Guggul (Commiphora and Boswellia) for Prevention of Chronic Diseases.

Extensive research during last 2 decades has revealed that most drugs discovered today, although costs billions of dollars for discovery, and yet they are highly ineffective in their clinical response. For instance, the European Medicines Agency has approved 68 anti-cancer drugs, and out of which 39 has reached the market level with no indication of increased survival nor betterment of quality of life. Even when drugs did improve survival rate compared to available treatment strategies, most of these were found to be clinically insignificant. This is a fundamental problem with modern drug disc

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… Various phenolic compounds such as hydroxybenzoic acid derivatives such as gallic acid, protocatechuic acid, gentisic acid, vanillic acid, p-hydroxy benzoic acid, syringic acid, ellagic acid, and cinnamic acid derivatives which include caffeic acid, chlorogenic acid, ferulic acid, sinapic acid (SA), … Effect of a natural supplement containing Curcuma longa , guggul, and chlorogenic acid in patients with metabolic syndrome. Angiology 66, 856–861. 10.1177/0003319714568792 Prabhavathi K., Chandra U. S., Soanker R., Rani P. U. (2014). …

From laboratory to clinic: opportunities and challenges of functional food active ingredients in cancer therapy.

This review provides a comprehensive analysis of the potential of functional food active ingredients in cancer prevention and therapy. It outlines the multifaceted anticancer mechanisms of bioactive compounds-such as polyphenols, carotenoids, omega-3 fatty acids, phytosterols, alkaloids, isothiocyanates, polysaccharides, phenolic acids, flavonols, and amide-bearing compounds-which include antioxidant and anti-inflammatory activities, induction of apoptosis and autophagy, modulation of the tumor microenvironment, interference with cell cycle regulation and signaling pathways, and regulation of

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… Combination treatments with chlorogenic acid show synergistic miRNA modulation affecting miR-144-3p (2.2-fold upregulation) in hepatocarcinogenesis prevention studies ( 105 ). 3.5 Anticancer mechanisms of isothiocyanates 3.5.1 Induction of apoptosis and cell cycle arrest Isothiocyanates (ITCs) are … Chlorogenic acid induces cancer differentiation through coordinated miRNA regulation. Key miRNAs include miR-20a, miR-93, and miR-106b, which regulate p21 targeting through the seed sequence AAGUGC. …

Терапевтическая ориентация на нейроинфламацию, вызванную ожирением, и нейродегенерацию.

Ожирение является одним из основных из изменяемых факторов риска, ведущих к нейроинфламмации и нейродегенерации. Чрезмерное содержание жира в ожирении способствует постепенному проникновению иммунных клеток в жировые ткани, что приводит к высвобождению провоспалительных факторов, таких, как цитокины и адипокины. Эти подстрекательские посредники циркулируют по кровотоку, пропагандируя воспаление как на периферии, так и в центральной нервной системе. Гут дисбиоз, который приводит к утечке кишечного барьера, усугубляет воспаление и играет важную роль в увязке ожирения с патогенезом нейроинфламмац

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… A natural dietary supplement (NDS) containing curcuma longa, silymarin, guggul, chlorogenic acid and inulin was shown to reduce the activation of astrocytes, ROS, lipid peroxidation and NF-ĸβ, IL-6 and IL-1β levels in the cerebral cortex of HFD mice, indicative of antioxidant and anti-inflammatory effects …

Bioactivity of the Genus Turnera: A Review of the Last 10 Years.

Turnera is a genus of plants whose biological activity has been widely studied. The importance of this genus, particularly Turnera diffusa, as a source of treatment for various conditions is evidenced by the large number of new studies that have evaluated its biological activity. Accordingly, the objective of this review was to compile the information published in the last ten years concerning the biological activities reported for Turnera spp. The present work includes 92 publications that evaluate 29 bioactivities and toxicological and genotoxic information on five species of this genus. Amo

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… Through an HPLC-DAD analysis, they identified chlorogenic acid (6) ( Figure 1 ), apigenin, luteolin-7-O-glucoside (7) ( Figure 1 ), and vitexin as the major components in this extract. … Although chlorogenic acid and some flavonoids have been identified in the active extract, it is essential to continue isolation studies to establish which of the components of the extract are responsible for this activity. 3.11. …

Effect of N-Acetylcysteine on Cisplatin Toxicity: A Review of the Literature.

N-acetylcysteine (NAC) is a membrane-permeable cysteine precursor capable of enhancing the intracellular cysteine pool, enhancing cellular glutathione (GSH) synthesis, and thus potentiating the endogenous antioxidant mechanism. Late administration of NAC after cisplatin has been shown in different in vivo studies to reduce the side effects caused by various toxicities at different levels without affecting the antitumor efficacy of platinum, improving total and enzymatic antioxidant capacity and decreasing oxidative stress markers. These characteristics provide NAC with a rationale as a potenti

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… TLR4/inflammasomes cross-talk and pyroptosis contribute to N-Acetyl cysteine and chlorogenic acid protection against cisplatin-induced nephrotoxicity. Pharmaceuticals . 2023;16(3):337. doi: 10.3390/ph16030337 30. Ramkumar V, Mukherjea D, Dhukhwa A, Rybak LP. …