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Distinguishing Human Peripheral Blood NK Cells from CD56dimCD16dimCD69+CD103+ Resident Nasal Mucosal Lavage Fluid Cells.

Natural killer (NK) cells are members of the innate lymphoid cells group 1 (ILC1s), which play a critical role in innate host defense against viruses and malignancies. While many studies have examined the role of circulating peripheral blood (PB) CD56+ NK cells, little is known about the resident CD56+ cell population. Therefore, matched CD56+ cells from nasal lavage fluid (NLF) and PB of smokers and non-smokers were compared phenotypically, via flow cytometry, and functionally, via NK-cell specific gene expression. NLF and PB CD56+ cells had similar expression of CD56, but differentially expr…

Nicotine consumption may lead to aseptic loosening in proximal mega-prosthetic femoral replacement.

BACKGROUND: Aseptic loosening after total hip arthroplasty is likely related to nicotine ingestion. However, aseptic loosening as a direct c … patients with 27 prostheses were included. Five patients were active smokers, and 21 patients were non-smokers. Aseptic loosening was observed in three patients in the smoking group, whereas none of the non-smokers developed aseptic loosening. Fisher's exact test showed a relationship between nicotine consumption and aseptic loosening of the prostheses (p = …

Successful breast reconstruction using acellular dermal matrix can be recommended in healthy non-smoking patients.

INTRODUCTION: We present Scandinavia's first series of immediate alloplastic breast reconstructions with an acellular dermal matrix. MATERI … se due to necrosis and/or wound dehiscence (10%) and two due to infection (3%). The failure rate in non-smokers was 2/52 (4%) compared with 8/24 (33%) in smokers, p = 0.001. In hypertensive patients, the failure rate was 6/12 (50%) compared with 4/64 (6%)in normotensive patients, p = 0.001. 70% of the failed reconstructions occurred in patients older than 65 …

Adherence to Tobacco Dependence Treatment Among HIV-Infected Smokers.

High prevalence of tobacco use and low success in quitting remain significant problems for reducing disease burden among HIV-infected persons. This study's purpose was to examine participant responsiveness and tobacco dependence treatment adherence and their influences on tobacco abstinence among HIV-infected patients. This non-randomized study included HIV-infected smokers 18 years of age or older, who smoked at least 5 cigarettes per day, and had an interest in quitting smoking in the next 30 days. HIV-infected smokers (n = 247) received a 12-week tobacco dependence treatment intervention th

[Comparing investigations of the valence of acetylcholine test and the closing volume for the early detection of non-specific lung diseases (author's transl)].

Investigations in 77 healthy persons and 94 patients with a manifest obstructive lung disease have led to the result that not only the central but also the peripheral part of the bronchial system are influenced by the bronchial reactivity. Accordingly the examination of the bronchial reactivity (0.01% acetylcholine solution as ultrasonic aerosol) enable in healthy persons a certain differentiation between smokers and non-smokers if the single breath test by means of the slope index are used. Therefore the method of investigation may be recommended for the early detection of functional disorder…

Tobacco smoking (up to 10 cigarettes daily) and lung functions in pregnant women.

The main objective of this paper was to study the effect of tobacco smoking (up to 10 cigarettes daily) on lung functions of healthy pregnant women as part of a large scale foetus antenatal care programme. Seventy eight pregnant women with no history and clinical evidence of pulmonary, cardiac, obstetrical or gynecological diseases were subjected to a comprehensive functional investigation of breathing. The women, all in the tenth lunar month of pregnancy, were divided into four categories: non-smokers, ex-smokers that have quitted smoking after diagnosing of pregnancy, with a mean of 2.0 +/- …

Investigating attentional bias in low-dependence smokers with steady-state visual evoked potentials (SSVEPs): Linking wanting, liking, and neural responses.

While traditional electrophysiological measures such as ERPs have been successfully used to study individual differences, their signal-to-no … obacco smoking-related attentional bias. A total of 39 participants, including smokers (N = 22) and non-smokers (N = 17), were exposed to a passive visual oddball paradigm comprising rapidly flickering stimuli under two conditions: neutral (e.g., office tools) and smoking-related (e.g., cigarettes). Neural activity was recorded using EEG, and frequency-specif …

Воздействие курения на клинические результаты лечения окролизумаба множественным склерозом.

ВВЕДЕНИЕ: Курение постоянно увязывается с ускорением развития болезней в множестве склерозов (MS), однако его воздействие в контексте современных методов лечения заболеваний, таких, как острелизумаб, остается неясным. В этом исследовании была проведена оценка взаимосвязи между курением и связанными с НР клиническими результатами на основе данных, основанных на утверждениях, у пациентов, которые активно лечатся окролизумаб. Мы провели ретроспективное когортное исследование на основе претензий с использованием исследовательской сети TriNetX, которая объединяет электронные медицинские записи 106

Совпадение в аннотации оригинала
INTRODUCTION: Smoking has been consistently linked to accelerated disease progression in multiple sclerosis (MS), but its impact in the cont … s, and mortality. Cox proportional hazards models were used to compare outcomes between smokers and non-smokers. RESULTS: Among 5998 patients (mean age 45.0 years; 60 % female), smokers had similar rates of optic neuritis (HR 1.33; 95 % CI, 0.93-1.90), but higher risk of extremity weakness (HR 1.43; 95 % CI, 1.17-1.76), seizures (HR 3.24; 95 % CI, 2.11-4.98) …

Identifying Predictors of Smoking Switching Behaviours Among Adult Smokers in the United States: A Machine Learning Approach.

Completely abstaining from cigarette smoking or fully switching to e-cigarette (EC) use may be beneficial for reducing the global burden of smoking-related diseases. This study aimed to identify and compare the top 10 prospective predictors of smokers switching away from smoking in the United States. Data from adult exclusive cigarette smokers at Wave 4 of the Population Assessment of Tobacco and Health (PATH) study, who were followed up at Wave 6, were analysed. An Xgboost-based machine learning (ML) approach with a nested cross-validation scheme was utilised to develop a multiclass predictiv

Optimizing tissue expander breast reconstruction in nicotine users: An algorithmic approach.

INTRODUCTION: Smoking is a risk factor for post-operative complications following breast reconstruction. Abruptly refraining from all nicoti … onstruction on the day of mastectomy and were divided into Group II (active smokers) and Group III (non-smokers). Group III was considered the control group. RESULTS: There was a total of 195 patients (323 breast reconstructions): Group I (10 patients, 19 expanders); Group II (11 patients, 19 expanders) and Group III (174 patients, 285 expanders). In Group I …

The Effect of Smoking and Body Mass Index on The Complication Rate of Alloplastic Breast Reconstruction.

BACKGROUND AND AIMS: The aim of this study was to evaluate the effect of smoking and body mass index on the occurrence of complications afte … patients had a complication. As much as 46% of smokers had severe complications compared to 18% of non-smokers. Of patients with body mass index ⩾ 25, 40% had severe complications compared to 10% with body mass index < 25. Smokers had eight times more chance of developing severe complications than non-smokers (ORadjusted = 8.0, p = 0.02). Patients with body …

Cigarette smoking prevalence among adults with HIV compared with the general adult population in the United States: cross-sectional surveys.

BACKGROUND: The negative health effects of cigarette smoking and HIV infection are synergistic. OBJECTIVE: To compare the prevalence of current cigarette smoking and smoking cessation between adults with HIV receiving medical care and adults in the general population. DESIGN: Nationally representative cross-sectional surveys. SETTING: United States. PATIENTS: 4217 adults with HIV who participated in the Medical Monitoring Project and 27 731 U.S. adults who participated in the National Health Interview Survey in 2009. MEASUREMENTS: The main exposure was cigarette smoking. The outcome measu

Impact of smoking and periodontitis on salivary IL-39, IL-41, IL-1β, and TNF-α levels: a cross-sectional analysis.

BACKGROUND: This study investigated the effects of periodontitis and smoking on salivary interleukin (IL)-39, IL-41, IL-1β, and tumor necros … diagnostic accuracy for distinguishing periodontitis from health in both smokers (AUC = 0.861) and non-smokers (AUC = 0.808), while the diagnostic capacity of IL-1β was impaired in smokers. CONCLUSIONS: Salivary IL-39 and TNF-α emerged as the most reliable biomarkers for distinguishing periodontitis from health, whereas IL-1β showed reduced diagnostic accur …

Passive Smoking Is Associated with the Risk of Functional Bowel Disorders Among College Freshmen.

Background: Functional bowel disorders (FBDs) have detrimental effects on young adults, but the risk factors were not fully explored. This study aimed to investigate the prevalence and potential risk factors of FBDs in college freshmen, including, in particular, the association between passive smoking and the risk and symptoms of FBDs. Methods: A cross-sectional study was conducted in September 2019 in freshmen of Huazhong University of Science and Technology with a random cluster sampling method. Validated questionnaires were voluntarily completed by participants. Rome IV criteria were applie

ADAM15 expression is increased in lung CD8+ T cells, macrophages, and bronchial epithelial cells in patients with COPD and is inversely related to airflow obstruction.

BACKGROUND: A disintegrin and metalloproteinase domain-15 (ADAM15) is expressed by activated leukocytes, and fibroblasts in vitro. Whether ADAM15 expression is increased in the lungs of COPD patients is not known. METHODS: ADAM15 gene expression and/or protein levels were measured in whole lung and bronchoalveolar lavage (BAL) macrophage samples obtained from COPD patients, smokers, and non-smokers. Soluble ADAM15 protein levels were measured in BAL fluid (BALF) and plasma samples from COPD patients and controls. Cells expressing ADAM15 in the lungs were identified using immunostaining. Stain…

Ineffectiveness of the Tobacco Hazards Prevention Act in patients with severe and persistent mental illness.

OBJECTIVES: The effect of the Tobacco Hazards Prevention Act (THPA) on the reduction of tobacco use in the general population in Taiwan is u … selected from a healthcare network. Then, 100 of 144 patients with SPMI, included 50 smokers and 50 non-smokers, have agreed with 1st year follow-up. Eighty-two patients with SPMI, consisted of 44 smokers and 38 non-smokers, have agreed with 2nd year follow-up. RESULTS: Although women were less likely to smoke than men, those who did smoke reduced the number …

Cell counting in human endobronchial biopsies--disagreement of 2D versus 3D morphometry.

QUESTION: Inflammatory cell numbers are important endpoints in clinical studies relying on endobronchial biopsies. Assumption-based bidimensional (2D) counting methods are widely used, although theoretically design-based stereologic three-dimensional (3D) methods alone offer an unbiased quantitative tool. We assessed the method agreement between 2D and 3D counting designs in practice when applied to identical samples in parallel. MATERIALS AND METHODS: Biopsies from segmental bronchi were collected from healthy non-smokers (n = 7) and smokers (n = 7), embedded and sectioned exhaustively. Syst…

Effects of smoking on renal function in patients with type 1 and type 2 diabetes mellitus.

BACKGROUND: Smoking increases the risk of end-stage renal failure in patients with primary renal disease. Whether and to what extent smoking … mokers were younger (47+/-14 vs 54+/-16 years, P < 0.01), and had a lower GFR (95+/-26 ml/min) than non-smokers (107+/-33 ml/min, P < 0.05). Mean GFR remained constant during follow-up in non-smokers (106+/-31 ml/min), but decreased significantly in smokers (83+/-22 ml/min, P < 0.0001), and this relationship persisted when adjusted for retinopathy, glycaemic …

Respiratory findings in gun factory workers exposed to solvents.

OBJECTIVE: Gun factory workers are exposed to many solvents (toluene, acetone, butanol, xylene, benzene, trichloroethylene). We investigated … were grouped according to their smoking habits (smokers, [exposed n: 353 vs. unexposed n: 339] and non-smokers [exposed n: 58 vs. unexposed n: 341]). Asthma-related symptoms were defined as either definite asthma, probable asthma, and possible asthma. RESULTS: In non-smokers, the report of asthma-related symptoms was more prevalent in exposed workers than u …

Comparing the efficacy of two Internet-based, computer-tailored smoking cessation programs: a randomized trial.

BACKGROUND: Online computer-tailored smoking cessation programs have not yet been compared directly. OBJECTIVE: To compare the efficacy of two Internet-based, computer-tailored smoking cessation programs. METHODS: Randomized controlled trial conducted in 2003-2004. Visitors to a smoking cessation website were randomly assigned to either an original online, interactive smoking cessation program or to a modified program. Both programs consisted of tailored, personalized counseling letters based on participants' characteristics, followed by monthly email reminders. The original program was base