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The evaluation of DLCO changes in patients with relatively higher lung shunt fractions receiving TARE.

OBJECTIVE: Transarterial radioembolization (TARE) with Yttrium-90 (90Y) labeled microspheres is an effective locoregional treatment option for patients with primary and metastatic liver cancer. However, TARE is also associated with radiation-induced lung injury due to hepatopulmonary shunting. If a large proportion of the injected radionuclide microspheres (more than 15%) is shunted, a rare but lethal complication may develop: radiation-induced pneumonitis (RP). Diffusion capacity of the lungs for carbon monoxide (DLCO) is a valuable test to assess lung function and a decrease in DLCO may indi

Variations in rifampicin and isoniazid resistance associated genetic mutations among drug naïve and recurrence cases of pulmonary tuberculosis.

BACKGROUND: The resistance to first-line drugs can increase the risk of treatment failure and development of resistance to other anti-TB dru … n was determined in naïve and recurrence cases. Some mutations were exclusively associated with the retreatment of 35anti-TB drugs which suggest the increased risk of resistance with poor treatment outcome.

Multimodality Treatment of Posterior Inferior Cerebellar Artery Aneurysms.

OBJECTIVE: Posterior inferior cerebellar artery (PICA) aneurysms are heterogeneous, uncommon lesions that can be treated in many fashions. M … and endovascular parent vessel occlusion: 6. There were 3 procedural complications. Recurrence and retreatment rates were 23.3% and 20.0%, respectively. Retreatments included coiling: 1; clipping: 4; and bypass: 1. Seven patients had an associated cerebellar arteriovenous malformation, of whom 5 have undergone resection. Good clinical outcome was achieved in …

Dysfunction of the thyroid gland during amiodarone therapy: a study of 297 cases.

AIM: This study aims to explore and compare the efficacy of radioiodine treatment (RIT) in hyperthyroid and euthyroid patients who have been … as, who were treated with AM and developed amiodarone-induced thyrotoxicosis, and currently require retreatment with AM. Group B: Hyperthyroid patients (92 M and 26 F, mean age 72±11.8 years) after AM therapy in the past. Group C: Hyperthyroid patients (66 M and 13 F, mean age 63.9±13.2 years) currently treated by AM. Group D: Hypothyroid patients (6 M and 16 …

Impact of vitreomacular adhesion on ranibizumab mono- and combination therapy for neovascular age-related macular degeneration.

PURPOSE: To investigate the influence of vitreomacular adhesion on the efficacy of pro re nata (PRN) ranibizumab monotherapy and verteporfin … r adhesion), and -113 μm (vitreomacular adhesion) in combination therapy (P=.924). Mean ranibizumab retreatments during 12 months were 4.9 (posterior vitreous detachment), 6.6 (release of vitreomacular adhesion), and 5.3 (vitreomacular adhesion) in monotherapy (P=.018) and 4.7 (posterior vitreous detachment), 5.2 (release of vitreomacular adhesion), and 5.8 ( …

Cohesive tensile strength of human LASIK wounds with histologic, ultrastructural, and clinical correlations.

PURPOSE: To measure the cohesive tensile strength of human LASIK corneal wounds. METHODS: Twenty-five human eye bank corneas from 13 donors that had LASIK were cut into 4-mm corneoscleral strips and dissected to expose the interface wound. Using a motorized pulling device, the force required to separate the wound was recorded. Intact and separated specimens were processed for light and electron microscopy. Five normal human eye bank corneas from 5 donors served as controls. A retrospective clinical study was done on 144 eyes that had LASIK flap-lift retreatments, providing clinical correlatio…

Tuberculosis in Hong Kong-patient characteristics and treatment outcome.

OBJECTIVES: To identify the general characteristics of patients with tuberculosis, and to evaluate their treatment outcomes. DESIGN: Retros … (5.2%) were patients who were retreated with a positive sputum smear, and 4134 (71.8%) were new or retreatment patients with a negative sputum smear. The overall treatment completion rates at 12 and 24 months were 80.4% and 84.8%, respectively. Males and patients aged 60 years or older had lower treatment completion rates. Non-adherence, transfer to other se …

High-dose intravenous pamidronate for metastatic bone pain.

The bisphosphonates are able to relieve pain from metastatic bone disease and, when given intravenously, may promote bone healing of lytic metastases. In this study, the aim was to assess the acute effects of a single 'high-dose' intravenous treatment with pamidronate on pain, mobility, analgesic consumption and quality of life (QOL). Thirty-four normocalcaemic patients with painful progressing bone metastases (22 from breast, five prostate and seven others) received a single intravenous infusion of 120 mg of pamidronate as palliative therapy. No other systemic therapy or drugs known to influe

Enterococcus faecalis and Endodontic Treatment Failure: A Qualitative Systematic Review of Its Role and Elimination Strategies.

The aim of this study was to synthesize evidence on the influence of Enterococcus faecalis on endodontic treatment failure and strategies fo … ltrasonic activation, reduced intraradicular bacterial load but achieved complete sterilization. In retreatment, two-visit protocols with intracanal medication improved microbiological outcomes, although calcium hydroxide efficacy depended on vehicle and duration. Adjunctive approaches showed mainly in vitro promise. Optimised disinfection and sealing remain …

Recurrent intraocular inflammation: Staphylococcus hominis endophthalmitis.

An 84-year-old highly myopic monocular male, with remote uncomplicated extracapsular cataract surgery without intraocular lens implantation … resolution. Seven months later, the same clinical picture recurred; despite prompt remission after retreatment, pars plana vitrectomy was added. No relapses occurred during 3 years of follow-up. Staphylococcus hominis was isolated from the removed whitish masses. Possible pathogenic mechanisms include bacterial sequestration within capsular remnants, recurre …

Subcutaneous daratumumab plus carfilzomib and dexamethasone (D-Kd) versus carfilzomib and dexamethasone (Kd) in patients with relapsed/refractory multiple myeloma who received previous daratumumab treatment: LYNX study.

Daratumumab-based regimens demonstrate clinical efficacy in relapsed/refractory multiple myeloma (RRMM). As more patients receive frontline daratumumab-based therapy, evaluation of daratumumab retreatment is needed. In the phase 2 LYNX study (ClinicalTrials.gov Identifier: NCT03871829), 88 patients with RRMM who received 1-3 prior lines of therapy, one of which contained daratumumab, were randomized to receive subcutaneous daratumumab plus carfilzomib/dexamethasone (D-Kd; n = 44) or carfilzomib/dexamethasone (Kd; n = 44). The primary endpoint was the very good partial response or better (≥VGPR…

Novel Flow Reversal Technique Using Dual-Balloon Inflation for Right Common Carotid Artery Stenosis: A Technical Case Report.

OBJECTIVE: Herein, we present a novel flow reversal technique using dual-balloon inflation that can provide enhanced catheter stability and reliable embolic protection for percutaneous antegrade stenting in a patient with right common carotid artery (CCA) stenosis. CASE PRESENTATION: A 75-year-old female patient with post-radiation right CCA stenosis initially underwent stenting using distal filter protection, which resulted in transient left upper limb paralysis caused by embolic infarction. After restenosis at 6 months, retreatment was performed using dual-balloon occlusion with the 9-F bal…

Мультимодальное лечение трехгеминиальной нейронгии, связанной с множественным склерозом: опыт одного центра.

ВВЕДЕНИЕ: Множество связанных со склерозом трехгеминиальных нейрологов (МСРТГН) является сложным заболеванием, которое часто является трудноразрешимым и связано с частыми рецидивами. Цель этого исследования заключается в изучении различных методов нейрохирургического управления этим заболеванием. МЕТОДЫ: В одном центре, где проходят ретроспективный анализ три различных метода: радиочастотная абляция (RF), радиохирургия гамма-ножа (GKRS) и микроваскулярная декомпрессия (MVD)-42 пациента, проходящих лечение для MSrTGN. Были проанализированы и сопоставлены результаты лечения, выживаемость без рец

Совпадение в аннотации оригинала
INTRODUCTION: Multiple sclerosis-related trigeminal neuralgia (MSrTGN) is a challenging disease, often intractable and associated with frequ … for MSrTGN were retrospectively analysed. Treatment outcomes, relapse-free survival, and repeat and retreatment procedures were analysed and compared across modalities. RESULTS: RF provided better initial pain control with higher VAS reduction compared to GKRS for MSrTGN patients. Time to second or third procedures and time to relapse did not differ signific …

Successful Management of Ovarian Cancer Progressing on Olaparib by Niraparib Following Cytoreduction: A Case Report.

BACKGROUND: Polyadenosine 5'-diphosphoribose polymerase inhibitors (PARP-Is) are novel, effective agents for treating newly diagnosed epithelial ovarian cancer (EOC). However, the effect of PARP-I on the progression of recurrent EOC has not yet been determined. In particular, there is limited evidence regarding retreatment with PARP-I for recurrent EOC that has progressed on PARP-I in the short term. CASE REPORT: A 69-year-old woman with a BRCA1 mutated EOC relapsed five months after starting olaparib maintenance following neoadjuvant chemotherapy and interval debulking surgery. Although the …

Chronic Hepatitis B Finite Treatment: Similar and Different Concerns With New Drug Classes.

Chronic hepatitis B, a major cause of liver disease and cancer, affects >250 million people worldwide. Currently there is no cure, only supp … ing trial design, patient selection, outcomes, biomarkers, predefined stopping criteria, predefined retreatment criteria, duration of investigational therapies, and follow-up after stopping therapy. Future research of unmet needs are discussed.

Femto-SMILE after photo-therapeutic keratectomy in an eye with failed LASIK flap: A case report.

PURPOSE: The aim of the study is to describe a case where Femtosecond Intrastromal Lenticule Extraction was used to address the refractive d … f 20/20. CONCLUSIONS AND IMPORTANCE: Femtosecond Intrastromal Lenticule Extraction can be used for retreatment after surface ablation. Topo-PTK can be used to ablate post-operative LASIK-induced irregularities with a successful outcome.

Beyond BCMA, why GPRC5D could be the right way: treatment strategies with immunotherapy at relapse after anti-BCMA agents.

Multiple Myeloma remains incurable, and there is a need for therapies with novel mechanisms of action. Recently, B cell maturation antigen targeted therapy has demonstrated deep and durable responses in a largely treated population. However, the relapse rate of myeloma patients after anti-BCMA treatment strategies is increasing worldwide, and one of the most challenging issues for them is to choose the best therapy sequencing. After anti-BCMA treatment, retreatment with anti-BCMA drugs remains an option, but new targets are emerging strongly. One of them is G protein-coupled receptor, class C …

Case Report: Acute Corneal Hydrops despite Accelerated Transepithelial Corneal Cross-linking.

SIGNIFICANCE: Corneal cross-linking is a well-established treatment to reduce or halt the progression of keratoconus. This case demonstrates … USIONS: Patients should continue to be monitored for several years after corneal cross-linking, and retreatment should be considered if there is progressive corneal thinning.

Derisking CD20-therapies for long-term use.

Anti-CD20 have quickly become the mainstay in the treatment of multiple sclerosis (MS) and other neuroinflammatory conditions. However, when … derisk anti-CD20 therapies, we need evidence-based approaches to reduce dosing intervals and guide retreatment.

[Research progress of outer retinal tabulation].

The outer retinal tubular structure (ORT) indicates a round or oval-shaped structure with a highly reflective border and a relatively low re … n spectrum-domain coherence tomography, but they are not an indication for neovascular activity and retreatment. Their response to anti-vascular endothelial growth factor is poor, and the visual prognosis is not optimistic. Therefore, raising awareness of ORTs is very important for guiding clinical treatment and judging prognosis. (Chin J Ophthalmol, 2020, 56 …