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Chronic lung disease in children and adolescents with HIV: a case-control study.

OBJECTIVE: To describe the features of HIV-associated chronic lung disease (CLD) in older children and adolescents living with HIV and to examine the clinical factors associated with CLD. This is a post hoc analysis of baseline data from the BREATHE clinical trial (ClinicalTrials.gov, NCT02426112). METHODS: Children and adolescents aged 6-19 years were screened for CLD (defined as a FEV1 z-score <-1 with no reversibility post-bronchodilation with salbutamol) at two HIV clinics in Harare, Zimbabwe, and Blantyre, Malawi. Eligible participants with CLD (cases) were enrolled, together with a cont…

Can visual interpretation of NucliSens graphs reduce the need for repeat viral load testing?

BACKGROUND: In Zimbabwe, viral load (VL) testing for people living with HIV on antiretroviral therapy is performed at the National Microbiology Reference Laboratory using a NucliSens machine. Anecdotal evidence has shown that invalid graphs for "Target Not Detectable (TND)" will upon repeat VL testing produce a valid result for virus not detected, therefore removing the need to repeat the test. This needs formal assessment. OBJECTIVES: To determine i) intra- and inter-rater agreement of the visual interpretation of NucliSens graphs (Target Detectable [TD], TND and No Line [NL]) between two la…

Insights for Implementation Science From 2 Multiphased Studies With End-Users of Potential Multipurpose Prevention Technology and HIV Prevention Products.

BACKGROUND: Lower adherence to biomedical HIV prevention and challenges with persistence among young women underscore the need for methods to identify factors that will achieve higher adoption and use of effective prevention options and inform new approaches. SETTING: South Africa, Kenya, and Zimbabwe. METHODS: We synthesized findings from 2 multiphased studies (TRIO and Quatro) conducted with young women aged 18-30 years that included a crossover clinical study with placebo products, a discrete-choice experiment, and qualitative interviews with women, male partners, and health providers. TR…

Local staff making sense of their tuberculosis data: key to quality care and ending tuberculosis.

<sec id="st1"> <title>BACKGROUND</title> The End TB Strategy's ambitious targets require universal health coverage, new tools and better data to monitor progress. </sec> <sec id="st2"> <title>OBJECTIVE</title> To assess the feasibility of a novel approach, whereby facility and district staff analyse and use their tuberculosis (TB) data to strengthen the quality of patient care and data. </sec> <sec id="st3"> <title>METHODS</title> This approach was piloted in Zimbabwe, and performance before and during the study were compared. Key indicators were defined for presumptive TB, TB disease, drug-re…

История туберкулеза связана с более низким уровнем выдохшегося окиси азота у ВИЧ-инфицированных детей.

ЦЕЛЬ: ВИЧ нарушает механизмы защиты принимающей стороны и поддерживает хроническое воспаление легких. Окись азота является маркером воспаления легких и может измеряться в выдохнутом воздухе. Мы изучили взаимосвязь между выдохшимся окисью азота (eNO), ВИЧ-статусом и аномалиями дыхательных путей у перинатальных ВИЧ-инфицированных детей в возрасте 6-19 лет. DESIGN: перекрестное исследование. МЕТОДЫ: В одной из государственных больниц в Хараре (Зимбабве) были завербованы ВИЧ-инфицированные лица с антиретровирусной терапией и ВИЧ-инфицированные дети без активного туберкулеза (ТБ) или острой инфекци

Совпадение в аннотации оригинала
OBJECTIVE: HIV disrupts host defense mechanisms and maintains chronic inflammation in the lung. Nitric oxide is a marker of lung inflammatio … rculosis (TB) or acute respiratory tract infection were recruited from a public hospital in Harare, Zimbabwe. Clinical history was collected and eNO testing and spirometry was performed. The association between eNO and explanatory variables (HIV, FEV1 z-score, CD4 cell count, viral load, history of TB) was investigated using linear regression analysis adju …

Survival from childhood cancers in Eastern Africa: A population-based registry study.

Cancers occurring in children in Africa are often underdiagnosed, or at best diagnosed late. As a result, survival is poor, even for cancers considered 'curable'. With limited population-level data, understanding the actual burden and survival from childhood cancers in Africa is difficult. In this study, we aimed at providing survival estimates for the most common types of cancers affecting children aged 0-14 years, in three population-based Eastern African registries; Harare, Zimbabwe (Kaposi sarcoma, Wilms tumour (WT), non-Hodgkin lymphoma (NHL), retinoblastoma, and acute lymphocytic leukaem…

Escherichia coli Contamination across Multiple Environmental Compartments (Soil, Hands, Drinking Water, and Handwashing Water) in Urban Harare: Correlations and Risk Factors.

Escherichia coli pathotypes (i.e., enteropathogenic and enterotoxigenic) have been identified among the pathogens most responsible for moder … ironmental reservoirs within households (N = 142) in high-population density communities of Harare, Zimbabwe. We further assessed the interconnectedness of the environmental compartments by investigating associations between, and household-level risk factors for, E. coli contamination. From the data we collected, the source and risk factors for E. coli con …

Systematic Literature Review on the Incidence and Prevalence of Heart Failure in Children and Adolescents.

While the epidemiology of adult heart failure has been extensively researched, this systematic review addresses the less well characterized … 8% (Norway) to 82.2% (Nigeria); associated with rheumatic heart diseases from 1.5% (Turkey) to 74% (Zimbabwe); associated with renal disorders from 3.8% (India) to 24.1% (Nigeria); and associated with HIV from 1% (US) to 29.3% (Brazil). To our knowledge, this is the first systematic review of the topic and strengthens current knowledge of pediatric HF epid …

Application of ethnobotanical repellents and acaricides in prevention, control and management of livestock ticks: A review.

Ticks transmit at least the same number or even more pathogens than any other group of blood-feeding arthropods worldwide affecting humans a … hich are traditionally used against ticks by native and local communities of Africa (Kenya, Uganda, Zimbabwe, South Africa), Europe (Serbia, Macedonia, Romania), Asia (Pakistan, India) and America (Brazil, Canada), from 56 families. However, only 7 families (i.e. Asteraceae, Euphorbiaceae, Fabaceae, Lamiaceae, Meliaceae, Apocynaceae and Solanaceae) represe …

Etiology of spinal cord injuries in Sub-Saharan Africa.

STUDY DESIGN: Review. OBJECTIVES: The aim is to highlight the epidemiology of spinal cord injuries (SCIs) in Sub-Saharan Africa in order to … e papers covered seven countries: Ethiopia, Ghana, Nigeria, Senegal, Sierra Leone, South Africa and Zimbabwe. In traumatic SCIs, motor vehicle accidents are the most frequent cause of injury followed by falling from a height and thirdly violence, being the most important cause of SCI in South Africa. In the Plateau State of Nigeria, collapsing tunnels in i …

Low genetic diversity in a snail intermediate host (Biomphalaria pfeifferi Krass, 1848) and schistosomiasis transmission in the Senegal River Basin.

Population genetic perturbations of intermediate hosts, often a consequence of human pressure on environmental resources, can precipitate un … vealed little population differentiation in SRB snails compared with those from natural habitats in Zimbabwe, where Schistosoma mansoni transmission is much lower. 'Open' SRB habitats are associated with greater water contact, smaller population sizes and less genetic diversity, with sites downstream of Richard-Toll showing greater inter- and intrapopulati …

Prevalence and correlates of substance use among school children in six African countries.

An increasing trend of noncommunicable diseases is a worldwide phenomenon, also including the developing countries. Few studies focus on adolescents' substance use in relation to mental distress and protective factors in African countries. The purpose of this study was to assess the prevalence and correlates (mental distress and protective factors) of substance use among school-going adolescents in six African countries. The sample included 20,765 students aged from 13 to 15 years from six African countries (Kenya, Namibia, Swaziland, Uganda, Zambia, Zimbabwe), chosen by a two-stage cluster sa…

Formative study conducted in five countries to adapt the community popular opinion leader intervention.

OBJECTIVE: To obtain information about the social and cultural factors related to health behaviors influencing HIV/sexually transmitted disease (STD) transmission in study communities in China, India, Peru, Russia, and Zimbabwe so that the assessment and intervention of the National Institute for Mental Health (NIMH) Collaborative HIV/STD Prevention Trial could be adapted appropriately. METHODS: Field observations, focus groups, in-depth interviews with key informants, and an observation of community social dynamics were conducted as part of a rapid ethnographic assessment. RESULTS: All five…

Demographic and social characteristics of regular donors who sero-converted in Harare.

Zimbabwe, like any other country, is currently experiencing a fast growing HIV/AIDS pandemic. A considerable number of infections are caused by blood transfusion. The aim of this study is to determine risk factors, events and socio-demographic characteristics associated with incidence of HIV infections and to prevent sero-conversion of regular blood donor. A retrospective cross sectional study was done. 22,922 regular donors at National Blood Transfusion Services in Harare were used. The number of all regular donors who sero-converted and their status during the 1999 to 2001 period were determ…

Identifying appropriate IUD candidates in areas with high prevalence of sexually transmitted infections.

BACKGROUND: The IUD is a highly effective, safe, inexpensive and long-lasting contraceptive. However, IUDs may increase PID risk during the early postinsertion period when inserted in women with cervical infections. We developed a simple algorithm to identify women at low risk of current sexually transmitted infection (STI) who are appropriate IUD candidates in regions with moderate or high STI prevalence. METHODS: We used data sets from family planning populations in Kenya, Zimbabwe, Jamaica and the United States to develop optimum algorithms. We then validated these algorithms using data se…

Complete genome analysis of 33 ecologically and biologically diverse Rift Valley fever virus strains reveals widespread virus movement and low genetic diversity due to recent common ancestry.

Rift Valley fever (RVF) virus is a mosquito-borne RNA virus responsible for large explosive outbreaks of acute febrile disease in humans and … 87, or Egypt, 1977 to 1978) exhibit little diversity, while those in enzootic settings (e.g., 1970s Zimbabwe) can be highly diverse. In addition, the large Saudi Arabian RVF outbreak in 2000 appears to have involved virus introduction from East Africa, based on the close ancestral relationship of a 1998 East African virus. Virus genetic diversity was low ( …

The relentless spread of tuberculosis in Zambia--trends over the past 37 years (1964-2000).

OBJECTIVE: To review trends in the rates of tuberculosis (TB) case notifications over a 37-year period. DESIGN: A retrospective study of Mi … in 2000. Comparison of case-notification rates over the past 2 decades with neighbouring countries (Zimbabwe, Malawi and Tanzania) show that Zambia has one of the highest case-notification rates in the region. CONCLUSIONS: Zambia, like many countries in Africa, is in the midst of a serious TB epidemic and there are no signs that it is abating. This increa …

HPV-based cervical cancer screening in a population at high risk for HIV infection.

We determined the utility of an assay for 13 cancer-associated HPV types in primary cervical cancer screening of Zimbabwe women at high risk of HIV infection. HIV antibody status was determined by ELISA of oral mucosal specimens, and HPV DNA in the genital tract was identified by hybridization of cervical scrapes with probe B of Hybrid Capture II. Among the 466 women investigated, the prevalence of HPV, low-grade squamous intraepithelial lesions (LGSIL) and high-grade SIL (HGSIL) were 47.2%, 13.9% and 12%. Fifty-three and one-half percent of the women were HIV-seropositive. As compared with HI…

Relationship of human herpesvirus 8 peripheral blood virus load and Kaposi's sarcoma clinical stage.

OBJECTIVE: To determine the relationship between human herpesvirus 8 (HHV-8 or Kaposi's sarcoma-associated herpesvirus) peripheral blood virus load and Kaposi's sarcoma (KS) clinical stage. DESIGN: Blinded, cross-sectional analysis of peripheral blood HHV-8 DNA levels in persons with AIDS-related KS in Harare, Zimbabwe. METHODS: Subjects were stratified by KS clinical stage. The amount of HHV-8 DNA in plasma and peripheral blood mononuclear cells (PBMC) was determined by quantitative real-time PCR amplification of the HHV-8 open reading frame 26. RESULTS: Thirty-one HIV-1/HHV-8-coinfected p…

Geostatistical analysis of baseline prevalence and treatment history drastically reduces the cost of soil-transmitted helminth impact assessment surveys.

BACKGROUND: Impact assessment surveys (IAS) are central to monitoring and evaluating the effectiveness of mass drug administration (MDA) pro … cy and survey cost. RESULTS: The methodology was applied to datasets from Kenya, Sierra Leone, and Zimbabwe. Compared to conventional survey designs, our model-based approach achieved similar classification accuracy with 60-90% lower survey costs. These gains were consistent across settings with different endemicity levels and deworming histories. The res …