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Role of circadian clock in oral squamous cell carcinoma pathogenesis and treatment.

The circadian clock is an endogenous timing mechanism that enables cellular physiological activities to adapt to environmental changes. It i … adian clock disruption in the development and progression of OSCC and summarizes recent advances in chronotherapy and therapeutic strategies targeting circadian clock genes, aiming to provide novel insights for the prevention and treatment of OSCC.

Circadian Rhythm, Clock Genes, and Hypertension: Recent Advances in Hypertension.

Accumulating evidence suggests that the molecular circadian clock is crucial in blood pressure (BP) control. Circadian rhythms are controlle … provide insight into potential future work in areas exploring the circadian clock in BP control and chronotherapy. A better understanding of peripheral clock function in regulating the circadian rhythm of BP will help pave the way for targeted therapeutics in the treatment of circadian BP dysregulation and hypertension.

BMAL1-mediated transcriptional regulation of CYP3A13 drives circadian rhythms in intestinal first-pass metabolism.

Intestinal first-pass metabolism serves as the primary metabolic barrier during the absorption of orally administered drugs, in which cytoch … y mechanisms of intestinal drug metabolism and provides a theoretical foundation for individualized chronotherapy in clinical practice.

Temporal immune surveillance in cancer: A circadian framework from mechanisms to chronotherapeutic integration.

From a traditional perspective, "immune surveillance" has long been regarded as a static process. However, recent studies have shown that th … tyle interventions such as time-restricted eating. Developing circadian biomarkers and personalized chronotherapy regimens is crucial for advancing precision oncology.

White Adipose Tissue and Circadian Rhythm Dysfunctions in Obesity: Pathogenesis and Available Therapies.

A combined neuroendocrine, metabolic, and chronobiological view can help to better understand the multiple and complex mechanisms involved in obesity development and maintenance, as well as to provide new effective approaches for its control and treatment. Indeed, we have currently updated data on the whole adipogenic process involved in white adipose tissue (WAT) mass expansion, namely due to a mechanism whereby WAT cells become hypertrophic, thus inducing a serious local (WAT) inflammatory condition that in turn, will impair not only the cross-talk between the hypothalamus and the WAT, but a

Disruption of circadian rhythms: a crucial factor in the etiology of depression.

Circadian factors might play a crucial role in the etiology of depression. It has been demonstrated that the disruption of circadian rhythms … ressive symptoms is far from being understood. The efficiency and the timing of treatments based on chronotherapy (e.g., light treatment, sleep deprivation, and scheduled medication) indicate that the circadian system is an essential target in the therapy of depression. The aim of the present review is to analyze the biological and clinical data that link depre …

The circadian-microbiome-immune axis in colorectal cancer: mechanisms of spatiotemporal immunosuppression and chronotherapeutic horizons.

Colorectal cancer (CRC) remains a major global oncological challenge, largely because most microsatellite-stable (MSS) tumors exhibit intrinsic resistance to immune checkpoint blockade (ICB). Emerging evidence suggests that the gut microbiome and host circadian rhythm jointly regulate mucosal homeostasis; however, their dynamic integration-defined here as the circadian-microbiome-immune axis-remains incompletely understood in CRC. In this review, we synthesize preclinical findings and the limited available clinical evidence concerning this axis. Experimental studies using genetic and lifestyle

Radiation-induced brachial plexopathy and hypofractionated regimens in adjuvant irradiation of patients with breast cancer--a review.

In order to increase the availability of adjuvant radiotherapy of breast cancer patients and make it more convenient and cheaper, in numerous cancer centres, the dose per fraction has been increased from 2 Gy to 2.25-2.75 Gy and the total dose has been decreased from 50 Gy to 40-45 Gy. The risk of developing any late complications after conventionally fractionated megavoltage radiotherapy is estimated to be below 1%. The aim of this review is to determine whether hypofractionated regimens increase the risk of damage to the brachial plexus. A review of the published literature shows that the us

Clinical study on chronopharmacokinetics of digoxin in patients with congestive heart failure.

Fluorescence polarization immunoassay was used to study the chronopharmacokinetics of digoxin in 10 patients with congestive heart failure (CHF) who also served as self-controls. Our results showed that the serum digoxin concentration reached peak value 1 h after taking digoxin at 7:00 a.m., but the serum digoxin concentration reached the peak value 2 h after taking digoxin at 4:00 p.m. The average serum digoxin concentration area under curve was greater and the best maintainable time of serum concentration within 24 h after taking digoxin at 4 p.m. longer than those at 7:00 a.m. The heart rat

Therapeutic applications of circadian rhythms for the cardiovascular system.

The cardiovascular system exhibits dramatic time-of-day dependent rhythms, for example the diurnal variation of heart rate, blood pressure, … f circadian biology including (1) timing of therapy to maximize efficacy in treating heart disease (chronotherapy); (2) novel biomarkers discovered by testing for genomic, proteomic, metabolomic, or other factors at different times of day and night (chronobiomarkers); and (3) novel pharmacologic compounds that target the circadian mechanism with potential clini …

Timekeepers of the gut: host circadian rhythms and microbial modulators.

The intestine is more than a digestive organ. It is a system under circadian control, where cellular renewal, barrier integrity, absorption, … robiota sustains health. Viewing the gut as a circadian conductor underscores new opportunities for chronotherapy and microbiota-targeted interventions.

BMAL1 Drives Cisplatin Resistance in Non-Small Cell Lung Cancer Via Lactate-MRP1 Signaling Pathway.

Lung cancer, the leading cause of cancer-related mortality, faces significant therapeutic challenges due to chemoresistance. While metabolic … ircadian dysfunction to chemoresistance and propose actionable strategies-such as AKT inhibition or chronotherapy-to circumvent therapeutic failure. This work underscores the necessity of targeting circadian-metabolic crosstalk to improve outcomes in NSCLC.

Хронобиология нейротропических вирусов: ритмичное вирусное проникновение и аритмические часы.

Нейротропиковые вирусы вторгаются в нейронные ткани, что приводит к серьезным заболеваниям, таким, как полиомиелит, бешенство, герпешвиральный энцефалит и вирусный менингит. Учитывая этот нейротропизм, мы изучили, находится ли инфекция носителя этих вирусов под контролем циркадов. В этом исследовании мы обнаружили, что выражение большинства нейротропиковых вирусных рецепторов имеет ритмичность по клеткам, церебральным органоидам и животным моделям, при этом чувствительная клеточная восприимчивость определяется циркадскими часами. Мы идентифицировали E2F8 как управляемый часами ген, который выс

Совпадение в аннотации оригинала
Neurotropic viruses invade neural tissues, resulting in severe diseases such as poliomyelitis, rabies, herpesviral encephalitis, and viral m … nteractions between circadian systems and neurotropic viral dynamics and highlight the potential of chronotherapy for improved antiviral treatments.

The role of the circadian system in the etiology and pathophysiology of ADHD: time to redefine ADHD?

Attention-deficit/hyperactivity disorder (ADHD) is highly associated with the delayed sleep phase disorder, a circadian rhythm sleep-wake di … n improvement of sleep quality, quantity, and phase-resetting, by means of improving sleep hygiene, chronotherapy, treatment of specific sleep disorders, and by strengthening certain neuronal networks involved in sleep, e.g., by sensorimotor rhythm neurofeedback. Ultimately, the main question is addressed: whether ADHD needs to be redefined. We propose a novel …

[Role of the pharmacopoeia in the prevention of jet-lag].

Long-haul flights allow rapid crossing of times zones. When four time zones are crossed, the transmeridian flight induce jet-lag syndrome. Jet-lag is essentially composed of digestive and behavioural disturbances (insomnia and/or drowsiness). It is due to an immediate conflict between external time cues, which have been phase-advanced or phase-delayed by eastward or westward flight, respectively, and the endogenous clock. This conflict induces a desynchronization of the biological rhythms. Different counter-measures could be advised, but the most used is the pharmacological one. Hypnotics like

Rhythms of mood: Bidirectional regulation of molecular clocks and neurotransmission in affective disorders.

Mood disorders, primarily major depressive and bipolar disorder, are characterized by significant neurochemical dysregulation and disturbances in biological rhythms. Recent evidence suggests for a complex, bidirectional interplay between the molecular circadian clock and major neurotransmitter systems, including monoamines (dopamine, serotonin, and norepinephrine), glutamate and GABA. While the suprachiasmatic nucleus acts as the master pacemaker, local clocks in limbic regions-such as the prefrontal cortex, hippocampus, ventral tegmental area and nucleus accumbens-maintain semi-autonomous osc

Protein Marker-Dependent Drug Discovery Targeting Breast Cancer Stem Cells.

Breast cancer is one of the most common cancers globally. Unfortunately, many patients with breast cancer develop resistance to chemotherapy … ntelligence (AI)-driven drug discovery and urge readers to seriously consider biological clocks and chronotherapy as experimental variables in drug discovery. Collectively, the task of cancer researchers is to overcome the many hurdles targeting BCSCs if we hope to tangibly improve breast cancer treatment outcomes and reduce mortality.

Reprogramming the Circadian Dynamics of Epileptic Genes in Mouse Temporal Lobe Epilepsy.

Temporal lobe epilepsy (TLE) is a common and severe epilepsy displaying rhythmicity in humans and animals. However, how the circadian clock … genes, shed light on possible TLE pathogenesis, and provide potential targets for TLE diagnosis and chronotherapy.

Insights about circadian clock in glioma: From molecular pathways to therapeutic drugs.

Glioma is characterized as the most aggressive brain tumor that occurred in the central nervous system. The circadian rhythm is an essential … ere are still many questions in this field waiting for further investigation. The results of glioma chronotherapy in sensitizing radiation therapy and chemotherapy have shown great therapeutic potential in improving clinical outcomes. These findings will help us further understand the characteristics of glioma pathophysiology.

Research progress on the interaction between circadian clock and early vascular aging.

Considerable researches implicate that the circadian clock regulates the responsive rhythms of organs and sets the orderly aging process of cells indirectly. It influences an array of diverse biological process including intestinal flora, peripheral inflammatory responses, and redox homeostasis. People with sleep disoders and other kinds of circadian disruptions are prone to have vascular aging earlier. Meanwhile, those people are always faced with chronic vascular inflammation. It has not been elucidated that the specific mechanism of the interaction between the circadian system and early vas