Результаты поиска

Множественный склероз и COVID-19: взаимодействие и нерешенные вопросы.

Серьезная симптоматическая инфекция SARS-COV-2 и осложнения COVID-19 вызывают особую озабоченность у людей с множественным склерозом, особенно у тех, кто принимает иммунодепрессанты или иммуномодуляторы. Исследования были направлены на выявление лиц с множественным склерозом, подверженных высокому риску заражения саранчой SARS-COV-2, анализ взаимодействия между SARS-COV-2 и множественным склерозом и оценку иммунологической реакции на инфекцию и вакцины с помощью SARS-COV-2. Формирование доминирующих вариантов SARS-COV-2, ряд имеющихся вакцин и новые терапевтические подходы требуют регулярного

Совпадение в аннотации оригинала
Serious symptomatic SARS-CoV-2 infection and COVID-19 complications are particular concerns for people with multiple sclerosis, especially those receiving immunosuppressants or immunomodulators. Studies have aimed to identify individuals with multiple sclerosis who are at high risk for SARS-CoV-2 infection, to analyse the interplay between SARS-CoV-2 and mul…

Иллюстрация бездействия: повторное изучение прогрессивных парадигм лечения множественным склерозом.

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Совпадение в полном тексте источника
… Active inflammation in “inactive” progressive multiple sclerosis: Traditionally, the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis (PMS) has been framed as an inflammatory versus degenerative dichotomy. … unmet clinical need in compartmentalized progressive multiple sclerosis (MS). Current therapies for active MS target systemic adaptive immune system-mediated immune attacks (left panel). …

Intranasal insulin for improving cognitive function in multiple sclerosis.

Cognitive impairment is common in people with multiple sclerosis (PwMS). There is an urgent need to identify/develop novel therapies that can help cognitive function in MS. Insulin is critical for helping with regulation of multiple CNS functions, including learning and memory. Insulin administrated intranasally has shown to improve memory and learning in healthy people and in those with some neurodegenerative disorders. Hence, there was rationale for investigating intranasal insulin in PwMS who experience cognitive impairment. We completed a phase Ib/II, randomized, double-blind, placebo-cont…

SARS-CoV-2 Вакцины и множественный склероз: обновление.

В высшей степени заразная зоонозная болезнь коронавируса 2019 (В тыс.COVID-19), вызванной острым острым респираторным синдромом коронавируса 2 (В тыс.SARS-CoV-2), была объявлена пандемией Всемирной организацией здравоохранения в марте 11, 2020, и это привело к глобальному кризису в области здравоохранения с почти 777 million подтвержденные инфекции и более 7 million к ноябрю 10, 2024.1-3 Со временем появились различные варианты, при этом Омикрон и его подлинии доминировали над миром в прошлом. 3 Годы.4 Кроме того, растет число свидетельств, касающихся иммунной реакции SARS-CoV-2 вакцины, особе

Совпадение в аннотации оригинала
The highly contagious zoonosis coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV- … ncreasing evidence regarding the immune response of SARS-CoV-2 vaccines, especially for people with multiple sclerosis (MS) receiving disease-modifying therapies. Hence, with this review, we aim to provide an updated overview and recommendations for clinical practice regarding MS and SARS-CoV-2 vaccines, including efficacy and safety, SARS-CoV-2 variants, vaccine he …

Лечение пациентов с множественным склерозом: факторы риска.

ВВЕДЕНИЕ: Соблюдение является фактором, поддающимся изменению в лечении заболеваний у пациентов с множественным склерозом (МС). Наша цель заключается в оценке факторов риска, связанных с недостаточным соблюдением. МЕТОД: Ретроспективное исследование на основе анализа медицинской документации и анализа базы данных о выдаче лекарств пациентам с РС третичной больницы с 2004 по 2022 год. Был проведен многовариантный логистический регрессионный анализ демографических, клинических, нозологических и терапевтических факторов между пациентами-кондиционистами и пациентами, не являющимися пациентами, и л

Совпадение в аннотации оригинала
INTRODUCTION: Adherence is a modifiable factor to disease-modifying treatments response in patients with multiple sclerosis (MS). Our objective is to assess the risk factors associated with inadequate adherence. METHOD: Retrospective study through review of medical records and review of the database of pharmaceutical dispensing of patients with MS of a tert…

Множественные склерозы и припадки: клинические, диагностические и терапевтические корреляции.

ВВЕДЕНИЕ: Изъятия происходят чаще среди лиц с множественным склерозом (ПМС), чем среди населения в целом. В настоящее время не проводится никаких исследований, в которых соотносятся клинические, диагностические и терапевтические результаты ПМС и изъятия. Определяем распространенность припадков (припадков) у людей с синдромом MS/Clinical Insidential (CIS) и характеризуем популяцию PCMS/CIS и припадки (припадки). Мы использовали регистр MS в Южном Уэльсе для идентификации всех людей, имеющих MS/CIS и всю историю припадков, проживающих в Кардиффе и Вале. Из электронных записей были получены ретро

Совпадение в аннотации оригинала
INTRODUCTION: Seizures occur more commonly in people with multiple sclerosis (pwMS) than in the general population. Existing studies correlating clinical, diagnostic and therapeutic outcomes for pwMS and seizures are lacking. We determine the prevalence of seizure(s) in people with MS/clinically isolated syndrome (CIS) and characterize a population-based coh…

Sorafenib inhibits multiple sclerosis by regulating T cell differentiation.

Multiple sclerosis (MS) is a group of disorder characterized by aberrant T cell reactivity toward self-antigens with loss of immunological tolerance, resulting in chronic inflammation and tissue damage. CD4+ Th cells can differentiate into Th1, Th2, Th17, and Treg cells in response to a specific class of pathogenic microorganisms and to the cytokine milieu. Here, we found that tyrosine kinase inhibitor sorafenib (Sora), which had been approved by FDA for the treatment of tumor, could suppress pro-inflammatory Th1, Th17 cell differentiation, and promote anti-inflammatory Treg cell polarization.…

Личная терапия при множественном склерозе: Итальянский Дельфийский консенсус.

ЦЕЛЬ: Все более широкое применение методов лечения, направленных на изменение болезней, может обеспечить более индивидуализированные варианты лечения множественного склероза (МС), основанные на различных факторах, включая характеристики пациентов, прогнозные показатели, коморбиды и безопасность. В Италии недавние усилия были сосредоточены на поощрении междисциплинарного и ориентированного на пациентов ухода и обеспечении равного доступа к оптимальным методам лечения, о чем сообщалось в < < Барометре > > с множественным склерозом и связанными с ним заболеваниями 2023 года из Итальян

Совпадение в аннотации оригинала
OBJECTIVE: The increasing availability of disease-modifying therapies (DMTs) may provide more personalized treatment options for multiple sclerosis (MS) based on various factors, including patients' characteristics, prognostic indicators, comorbidities, and safety. In Italy, recent efforts focused on promoting interdisciplinary, patient-centered care and equ…

Real-world persistence of multiple sclerosis disease-modifying therapies.

BACKGROUND AND PURPOSE: Treatment persistence is the continuation of therapy over time. It reflects a combination of treatment efficacy and tolerability. We aimed to describe real-world rates of persistence on disease-modifying therapies (DMTs) for people with multiple sclerosis (pwMS) and reasons for DMT discontinuation. METHODS: Treatment data on 4366 consecutive people with relapse-onset multiple sclerosis (MS) were pooled from 13 UK specialist centres during 2021. Inclusion criteria were exposure to at least one MS DMT and a complete history of DMT prescribing. PwMS in blinded clinical tr…

Pathogenesis of multiple sclerosis: genetic, environmental and random mechanisms.

BACKGROUND: The pathogenesis of multiple sclerosis (MS) requires both genetic factors and environmental events. The question remains, however, whether these factors and events completely describe the MS disease process. This question was addressed using the Canadian MS data, which includes 29 478 individuals, estimated to represent 65-83% of all Canadian patients with MS. METHOD: The 'genetically-susceptible' subset of the population, (G), includes everyone who has any non-zero life-time chance of developing MS, under some environmental conditions. A 'sufficient' environmental exposure, for a…

Multiple Sclerosis: Clinical Update and Clinically-Oriented Radiologic Reporting.

Multiple sclerosis (MS) is a chronic inflammatory disease of the nervous system. MR imaging findings play an integral part in establishing diagnostic hallmarks of the disease during initial diagnosis and evaluating disease status. Multiple iterations of diagnostic criteria and consensus guidelines are put forth by various expert groups incorporating imaging of the brain and spine, and efforts have been made to standardize imaging protocols for MS. Emerging ancillary imaging findings have also attracted increasing interests and should be sought for on radiologic examination. In this paper, the …

Neuropathic Pain Secondary to Multiple Sclerosis: A Narrative Review.

Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system (CNS). Neuropathic pain in MS is a debilitating symptom that significantly impairs the quality of life for a substantial proportion of MS patients. Neuropathic pain in MS stems primarily from demyelination, axonal loss, CNS inflammation, and direct damage to the myelin sheath, leading to pain manifestations such as ongoing extremity pain, Lhermitte's phenomenon, and trigeminal neuralgia (TN). The pathophysiological mechanisms behind MS-related neuropathic pain are explored in this review, highlighti…

Iatrogenic myelodysplastic syndrome complicating multiple sclerosis: A case report.

After 1.5 years of treatment with dimethyl fumarate (DMF) for multiple sclerosis, preceded 8 years earlier by intravenous (IV) cladribine and 1 year earlier by natalizumab, our patient developed myelodysplastic syndrome (MDS). The initial manifestation was a severe drop in absolute neutrophil and lymphocyte counts. Repeat bone marrow biopsy demonstrated a new unbalanced translocation (between the chromosome 1 long arm and chromosome 7 short arm). This case report, to our knowledge, is the first linking iatrogenic MDS to DMF and cladribine, while also suggesting caution with immunosuppressants …

Combination protein biomarkers predict multiple sclerosis diagnosis and outcomes.

Establishing biomarkers to predict multiple sclerosis diagnosis and prognosis has been challenging using a single biomarker approach. We hypothesised that a combination of biomarkers would increase the accuracy of prediction models to differentiate multiple sclerosis from other neurological disorders and enhance prognostication for people with multiple sclerosis. We measured 24 fluid biomarkers in the blood and cerebrospinal fluid of 77 people with multiple sclerosis and 80 people with other neurological disorders, using ELISA or Single Molecule Array assays. Primary outcomes were multiple scl…

Impact of symptomatic multiple sclerosis therapy on pregnancy outcome.

BACKGROUND: Information on symptomatic therapy (ST) use in women of childbearing age with multiple sclerosis is sparse, and data on the impact of ST pregnancy exposure on pregnancy outcome are lacking. OBJECTIVE: To investigate (1) ST use patterns pre-conception, during pregnancy and postpartum and (2) pregnancy outcomes. METHODS: Pregnancy data from the German Multiple Sclerosis and Pregnancy Registry were analyzed for the ST use from pre-conception to postpartum. Pregnancy outcomes were compared between ST-exposed (n = 282) and matched (disease modifying therapy and age) ST-naive (n = 536)…

Pineal gland volume loss in females with multiple sclerosis.

INTRODUCTION: Multiple sclerosis has a complex pathophysiology, and numerous risk factors can contribute to its development, like exposure to sunlight that is associated with serum levels of melatonin. The aim of this study was to determine whether the volume of the pineal gland, assessed by magnetic resonance imaging (MRI), correlated with the presence of multiple sclerosis. METHODS: This retrospective study included a total of 394 patients. Subjects were divided into two groups: the first group consisted of 188 patients with a definite diagnosis of multiple sclerosis (based on revised McDon…

Optic Nerve Imaging in Multiple Sclerosis and Related Disorders.

Optic neuritis is a common feature in multiple sclerosis and in 2 other autoimmune demyelinating disorders such as aquaporin-4 IgG antibody-associated neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein antibody-associated disease. Although serologic testing is critical for differentiating these different autoimmune-mediated disorders, MR imaging, which is the preferred imaging modality for assessing the optic nerve, can provide valuable information, suggesting a specific diagnosis and guiding the appropriate serologic testing.

Typical and Emerging Diagnostic MRI Features in Multiple Sclerosis.

Magnetic resonance imaging (MRI) stands as the most sensitive paraclinical technique for detecting the demyelinating lesions characteristic of multiple sclerosis (MS). Consequently, MRI plays a pivotal role in establishing an accurate and timely diagnosis of the disease, ultimately based on the application of the McDonald criteria. Early diagnosis is particularly important as it facilitates the prompt initiation of disease-modifying treatments, deemed most effective during the initial phases of MS. This review article examines the recommended standardized MRI protocol, as well as the classic i…