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An intra-abdominal malignant mesenchymoma associated with nonabsorbable sutures in a ferret (Mustela putorius furo).

A 6-year-old ferret (Mustela putorius furo) was presented with abdominal enlargement. Clinical examination revealed an intra-abdominal mass … a components. Immunohistochemistry revealed that both neoplastic cell populations were positive for vimentin and negative for actin (smooth and striated), desmin, and myoglobin. Nonabsorbable suture material was admixed with the neoplastic tissue in the histologic section. This material was birefringent when viewed microscopically under polarized light.

Inflammatory pseudotumours of the urinary bladder in dogs resembling human myofibroblastic tumours: a report of eight cases and comparative pathology.

Eight cases of inflammatory myofibroblastic tumours (IMT) of the urinary bladder in dogs are described, including their clinical, imaging, m … The cells were spindle-shaped, adopting a fascicular, pallisading or whirling organisation and were vimentin and variably desmin and actin positive. The nuclei were globular, containing open chromatin and prominent nucleoli. Mild to moderate pleomorphism and little mitotic activity were present. These morphological features are compatible with human myofib …

Sclerosing epithelioid fibrosarcoma of the pituitary.

Primary pituitary sarcoma in the absence of previous radiation therapy is very rare, only eight cases having been reported. We present the f … infrequently occurring, distinct variant of soft tissue fibrosarcoma. Its immunophenotype includes vimentin and occasionally CD-34, B cell lymphoma-2, S-100 protein, or keratin expression. Although initially thought to be a low-grade lesion, sclerosing epithelioid fibrosarcomas may also behave in a high-grade manner.

[Solitary fibrous tumor: a clinico-morphological and immunohistochemical study].

Solitary fibrous tumor is a rare neoplasm which may occur at any site although it is more frequent in the pleura, mediastinum and lung. The study used 4 cases of tumor localization in the pleura and orbit. Three cases presented as a "hemangiopericytic" variety of spindle cells; there were numerous giant cells in orbit tumor. Solitary fibrous tumor revealed enhanced expression of vimentin, CD34, bel-2 and CD99. Expression of S-100, desmine and non-striated muscle actin was found in few cells in some cases. Such features as large size (over 10 cm), necrosis, high cellularity, nuclear polymorphis…

Granulosa cell tumor arising in the wall of müllerian cyst of the broad ligament: report of a case and immunohistochemical study.

CASE: A unique case of granulosa cell tumor arising in a müllerian cyst of the broad ligament in a 57-year-old woman is presented. The surgically resected unilocular cyst, measuring 9.5 x 9.5 x 6.5 cm3, situated within the right broad ligament. The inner surface of the cyst was lined by a single layer of ciliated columnar cells. Solid cell sheath of the spindled cells were demonstrated in this cystic wall. Immunohistochemically, these spindled cells were diffusely positive for cytokeratin 7, AE1/AE3, vimentin, smooth muscle actin, calretinin and weakly positive for inhibin, but negative for cy…

Atypical fibrous histiocytoma of the scrotum.

Atypical fibrous histiocytoma is a rare neoplasm. A scrotal location for this tumor is even more unusual. We report a case of a 90-year-old … totic figures are identified. Immunohistochemical studies showed the tumor cells to be positive for vimentin, smooth muscle actin, desmin, KP-1, factor XIIIa, and MIB-1 (less than 10%). In addition to the expected immunohistochemical studies, the tumor stained diffusely positive for CD117. To our knowledge, this is the first report of atypical fibrous hist …

Cerebellar papillary meningioma in a 3-year-old boy: the usefulness of electron microscopy for diagnosis.

We report one case of papillary meningioma located in the posterior fossa in a 3-year-old boy. Despite a gross total resection, a major recurrence occurred 6 months later that was operated on. Eight months later, another recurrence was observed with intracranial metastases and dissemination throughout the cerebrospinal fluid. The tumor had a papillary architecture more obvious in the recurrence. Areas of necrosis were numerous. Tumor cells had large clear atypical nuclei. Many mitotic figures were seen and Ki-67 labeling index was high. The tumor cells were immunoreactive for vimentin and poly…

Solitary subcutaneous mucinosis surrounded by bizarre-shaped, factor XIIIa-positive cells with intranuclear vacuoles.

We describe a subcutaneous mucinosis developing in the right cheek of a 38-year-old man. Histologic examination revealed bipolar fibroblast-like cells embedded in a well demarcated mucinous stroma in the subcutis without a manifest reticulin network. In addition, bizarre, sometimes multinucleate, cells with intranuclear vacuoles were found at the periphery of the mucinous stroma. Immunohistologically, both the bipolar fibroblastic cells and bizarre-shaped cells were positive for vimentin, but were negative for smooth muscle A-actin, desmin, CD34, S100, trypsin, or chymotrypsin. However, the la…

[Olfactory neuroblastoma: a histopathological ultrastructural and immunohistochemical study of 11 cases].

Eleven cases of olfactory neuroblastoma (ONB) were studied histopathologically, ultrastructurally and immunohistochemically. Light microscop … results were obtained for the 11 neoplasms that were immunostained: NSE 11/11 (+), S-100 3/11 (+), Vimentin 4/11 (+), Keratin 1/11 (+) and NF, EMA, CEA, LCA all negative respectively. The significance of the morphological and immunohistochemical features of ONB in diagnosis and differential diagnosis were discussed.

Ependymoma of the uterosacral ligament.

Extraspinal ependymomas have been described in the subcutaneous sacrococcygeal and presacral areas. Since 1984, eight pelvic ependymomas hav … gs of cilia, blepharoplasts, and intermediate filaments. The tumor was positive for cytokeratin and vimentin. Ultrastructurally, neurosecretory granules were present within the cytoplasm. These features have not been described previously in pelvic ependymomas. These tumors, although easily confused with serous papillary carcinoma, should be distinguished f …

[Nitrosative stress promotes the malignant biological behavior of breast cancer through the glycolytic pathway].

OBJECTIVES: Breast cancer is one of the most common malignant tumors in women, and some patients face poor therapeutic efficacy and recurren … two drugs. Western blotting was used to detect the expression levels of E-cadherin, N-cadherin, and vimentin, as well as glycolysis-related proteins hexokinase 2 (HK2), pyruvate kinase M2 (PKM2), and enolase 1 (ENO1). RESULTS: The expression levels of iNOS and 3-NT in breast cancer tissues were significantly higher than those in normal breast tissues (P<0 …

[Protective effect of active vitamin D on liver fibrosis induced by sodium arsenite in SD rats].

OBJECTIVE: To explore the protective effect of active vitamin D(VD) on liver fibrosis injury induced by sodium arsenite(NaAsO_2) in SD rats. … levels of fibrosis-related markers α-smooth actin(α-SMA), transforming growth factor-β1(TGF-β1) and Vimentin in each group. RESULTS: After 36 weeks of NaAsO_2 exposure, the weight of rats was significantly decreased compared with the control group, and the weight of female rats after calcitriol intervention was significantly increased compared with NaAsO_ …

Воздействие ортофлавироза Тика-Борна на эндотелиальный барьер человеческого мозга.

Энцефалит, передаваемый через тик, по-прежнему является серьезным бременем для здоровья человека в эндемических районах Центральной Европы и Восточной Азии. Вирус энцефалита (TBEV) — нейротропический вирус, принадлежащий роду ортофлавивирусов. После того как ТБЭВ попадает в центральную нервную систему (СНС), он в основном нацелен на нейроны, вызывая энцефалит и приводя к пожизненной инвалидности, коме и, в редких случаях, смерти. Нейроинвазивные механизмы ортофлавиирузы плохо понимаются. Здесь мы исследуем механизм нейронного вторжения ТБЭВ, гипотеза о том, что ТБЭВ влияет на свойства мозговог

Совпадение в аннотации оригинала
Tick-borne encephalitis remains a significant burden on human health in the endemic areas in Central Europe and Eastern Asia. The causative … TBEV was significantly affected when two cellular surface antigens, the laminin-binding protein and vimentin, were blocked with specific antibodies. Taken together, these results indicate that orthoflaviviruses use non-destructive transcellular routes through endothelial cells to establish infection within the CNS.

DNA methylation-associated repression of MEST/PEG1 expression contributes to the invasion of extravillous trophoblast cells.

INTRODUCTION: The invasion of extravillous cytotrophoblasts (EVTs) into the maternal uterine decidua and vasculature is critical for human p … ravillous explant outgrowth, which were associated with the downregulation of Twist, N-cadherin and Vimentin. Decreased MEST protein expression with isoform 2 promoter hypermethylation was observed in the placentas of missed abortions, suggesting a possible pathological mechanism of missed abortion. CONCLUSIONS: Suppressed expression of MEST was associate …

Pseudosarcomatous Vaginal Polyp.

BACKGROUND: Although rare, pregnant women can present with fibroepithelial polyps of the vagina. Most likely hormonally related, these polyps have been described in various locations of the lower female genital tract. They can be mistaken for malignant lesions due to hypercellularity and cytologic atypia. CASE: We describe the case of a 31-year-old woman who presented with a polyp of the vagina during a postpartum visit. RESULTS: Atypical cells were seen in hypercellular areas of the stroma of the polyp. CONCLUSION: A pitfall to avoid is classifying these benign lesions as malignant based o

Anti-MCV and anti-CCP antibodies-diagnostic and prognostic value in children with juvenile idiopathic arthritis (JIA).

The goal of the study was to evaluate the diagnostic and prognostic value of anti-mutated citrullinated vimentin (anti-MCV) antibodies in juvenile idiopathic arthritis (JIA) comparing to anti-cyclic citrullinated peptide (anti-CCP). Thirty children with confirmed JIA diagnosis and 20 children as a control group were included into the study. Serum and synovial fluid levels of anti-CCP, anti-MCV, and immunoglobulin M rheumatoid factor (IgM-RF) antibodies have been assessed. Anti-MCV was positive in 11/30 (36.6 %), whereas anti-CCP positivity was found in 12/30 (40 %) children with JIA. Among 11 …

Cystic rete testis with testicular dysplasia in a rabbit.

An 8-year-old intact rabbit was presented to a veterinary hospital with a complaint of enlarged left scrotum. Histological examination revea … e round cells with cytoplasmic lipid droplets (Leydig cells). Both of these cells were positive for vimentin and melan A that are consistent with the staining pattern of Sertoli cells and Leydig cells. This is the first report to demonstrate cystic rete testis with testicular dysplasia in animals.

Primary intraparotid peripheral nerve sheath tumour with characteristics of benign schwannoma in a horse.

Schwannomas arising in the parotid gland are rare in man and are not documented in domestic animals. This report describes the clinical, mor … tern and intermixed with hypocellular areas resembling the Antoni B pattern. Tumour cells expressed vimentin, S100 protein, glial fibrillary acidic protein and variably neuron-specific enolase. Less than 5% of the neoplastic cells were immunolabelled with the proliferation marker Ki67. Although malignant melanomas frequently involve the parotid gland in ho …

Colonic malignant melanoma, primary or metastatic? Case report.

Gastrointestinal malignant melanomas, either primary or metastatic, are rare and overlooked tumors. There is also controversy regarding the … ined apparent brown pigment, most were found to be positive for S-100 protein, HMB-45, Melan-A, and vimentin. The possibility of a metastatic lesion was considered. While the patient had a history of a pathologically examined dorsal nevus excision two years before, there was no evidence of either cutaneous or ocular primary melanoma at the time of diagnosi …

Peripheral ossifying fibroma: a clinical and immunohistochemical study of four cases.

Peripheral ossifying fibroma (POF) is a lesion of the gingival tissues that predominantly affects women and is usually located in the maxilla anterior to the molars. The definitive diagnosis is established by histological examination, which reveals the presence of cellular connective tissue with focal calcifications. Surgery is the treatment of choice, though the recurrence rate can reach 20%. We present a clinical and histological review - including a detailed immunohistochemical analysis - of four cases of POF diagnosed and treated at our hospital. All four patients were women, and two were