Результаты поиска

Acquired pendular nystagmus in multiple sclerosis and oculopalatal tremor.

OBJECTIVE: Acquired pendular nystagmus occurs mainly in multiple sclerosis (MS) and focal brainstem lesions. In the later case, it is part of the syndrome of oculopalatal tremor. Even though pathophysiology of acquired pendular nystagmus has been clearly characterized experimentally in both etiologies, there is a persisting ambiguity in clinical literature, which leads one to consider both clinical conditions as a common entity. The objective of our work was to compare in a prospective study clinical features, eye movement recording, and functional consequences of acquired pendular nystagmus i…

Recent advances in optic neuritis related to multiple sclerosis.

More advanced methods of detecting and quantifying optic neuritis (ON) in multiple sclerosis have been developed in the past 15 years. This review focuses on developments in optical coherence tomography (OCT) measurement of the retinal nerve fibre layer (RNFL) and its role in monitoring axonal loss in the course of the disease. New clinical trial methods of measuring visual acuity (VA) include high-contrast VA testing with Early Treatment Diabetic Retinopathy Study charts, low-contrast letter acuity and contrast sensitivity testing. Multi-focal visual evoked potentials have been used to detect…

Relapse severity and recovery in early pediatric multiple sclerosis.

BACKGROUND: Factors determining severity and recovery of early demyelinating events in pediatric multiple sclerosis (MS) patients are unknown. OBJECTIVE: The objective of this study was to characterize the severity and recovery of early demyelinating events in pediatric MS. METHODS: Multivariate logistic regression was performed to determine predictors of severe (versus mild/moderate) relapses and poor or fair (versus complete) recovery in patients aged 18 years or less with MS or clinically isolated syndrome (CIS). RESULTS: Optic nerve involvement (OR 4.30, 95% CI 1.50-12.3, p = 0.007) was…

Множественный склероз: расстройство перестроенного T-Cell Homeostasis

Существует неопределенность в отношении того, способствуют ли аналогичные или различные механизмы патогенезу различных подтипов множественного склероза (МС). Детальный анализ наивного гомеостазиза клеток Т показывает, что пациенты с повторно излучающими MS (RRMS) и с первичным прогрессивным MS (PPMS) имеют раннее наступление тимической инструкции, что приводит к снижению тимической производительности. Снижение тимической производительности приводит к вторичным периферийным гомеостатическим изменениям в наивных CD4 Т-клеток, которые тесно имитируют изменения Т-клеток, наблюдаемые в эксперимента

Совпадение в аннотации оригинала
Uncertainty exists as to whether similar or different mechanisms contribute to the pathogenesis of different subtypes of multiple sclerosis (MS). Detailed analysis of naive T cell homeostasis shows that patients with relapsing-remitting MS (RRMS) and with primary progressive MS (PPMS) have early-onset thymic involution that causes reduced thymic output. The …

Supratentorial multiple sclerosis lesions affect the blink reflex test.

INTRODUCTION: The Blink Reflex Test (BRT) is a neurophysiological examination used for evaluation of brainstem reflex circuits. MRI is the most precise modality for evaluation of MS lesion anatomy. Our study objective was to investigate how the functional results of the neurophysiological BRT relate to the anatomy of MS lesions in routine MRI studies. METHODS: 65 MS patients underwent the BRT within 2 months of a brain MRI showing demyelinating lesions. RESULTS: The overall sensitivity of the BRT was 90.8%, while in patients with at least one brainstem lesion and no brainstem lesions it was

Chronic cerebro-spinal venous insufficiency (CCSVI) and multiple sclerosis.

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the CNS caused by the interplay of genetic and environmental factors. In the last years, it has been suggested that an abnormal venous drainage due to stenosis or malformation of the internal jugular and/or azygous veins may play a major pathogenetic role in MS. This abnormality called chronic cerebro-spinal venous insufficiency (CCSVI) could result in increased permeability of blood brain barrier, local iron deposition and secondary multifocal inflammation. In the present paper, literature data in favour and against this hypo…

[Pain in multiple sclerosis: prevalence, mechanisms, types and treatment].

INTRODUCTION: Pain is a frequent symptom in multiple sclerosis (MS), although its prevalence and its importance vary from one study to another. AIM: To analyse the prevalence, types, mechanisms and treatments of the different painful syndromes that affect patients with MS. DEVELOPMENT: The work includes a non-systematic review of the literature on the above-mentioned aspects in patients with MS. The prevalence of pain in this disease is higher than what was initially supposed and some series estimate it to be up to 86%. It has important effects on patients' quality of life, limiting both the…

Becoming mothers. Multiple sclerosis and motherhood: a qualitative study.

PURPOSE: This study aimed to provide a better understanding of the experiences of women with multiple sclerosis (MS) in becoming or being a mother. The research also focused on eliciting their perspectives of strategies that helped them and their families manage mothering young children whilst living with MS. METHOD: A qualitative, interpretive, descriptive approach using individual interviews to elicit and analyze women's experiences of MS and pregnancy, birth, and mothering young children. RESULTS: Analysis of interviews with nine women produced six key themes: becoming a mother as a publi…

Vitamin D, pregnancy, breastfeeding, and postpartum multiple sclerosis relapses.

OBJECTIVE: To determine whether low levels of 25-hydroxyvitamin D (25[OH]D) contribute to the increased risk of postpartum multiple sclerosis (MS) relapses. DESIGN: Prospective cohort study. SETTING: Outpatients identified through membership records of Kaiser Permanente Northern California or Stanford University outpatient neurology clinics. PATIENTS: Twenty-eight pregnant women with MS. INTERVENTIONS: We prospectively followed up patients through the postpartum year and assessed exposures and symptoms through structured interviews. Total serum 25(OH)D levels were measured using the DiaSor…

Successful treatment of co-morbid schizophrenia and multiple sclerosis.

Multiple sclerosis (MS) has both neurological and psychiatric manifestations. Though depression, bipolar disorder and la belle indifference are commonly described, schizophrenia-like-psychosis is not widely reported with MS. Drug interactions and side effects make treatment, in such scenario, challenging. We, for the first time, report a patient with MS and paranoid schizophrenia successfully treated with concurrent use of clozapine and risperidone with interferon-beta-1a.

Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis.

BACKGROUND: Fingolimod (FTY720), a sphingosine-1-phosphate-receptor modulator that prevents lymphocyte egress from lymph nodes, showed clinical efficacy and improvement on imaging in a phase 2 study involving patients with multiple sclerosis. METHODS: In this 12-month, double-blind, double-dummy study, we randomly assigned 1292 patients with relapsing-remitting multiple sclerosis who had a recent history of at least one relapse to receive either oral fingolimod at a daily dose of either 1.25 or 0.5 mg or intramuscular interferon beta-1a (an established therapy for multiple sclerosis) at a wee…

Multiple sclerosis: an update for oral health care providers.

Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease of the central nervous system. The disease mostly affects young adults and is increasing in prevalence and incidence. Multiple sclerosis is characterized by periods of activity and remission which, after numerous relapses, cause permanent neurologic deficits. Diagnosis of MS is based on patient history and clinical examination supplemented by the findings of radiologic and laboratory tests. Numerous motor and sensory disturbances occur in MS and may present in the orofacial region. This medical management update highligh…

Multiple sclerosis. Part 2: ophthalmic issues in MS therapy.

PURPOSE OF REVIEW: This update includes topics relating to the treatment of multiple sclerosis (MS) for the ophthalmologist. RECENT FINDINGS: Despite investigation into numerous genetic and environmental factors, the cause of MS remains elusive. MS is a disease of the central nervous system that mainly affects young people and usually progresses over time, leading to disability in multiple areas, including mobility, cognition, affect and vision. It is likely that, as novel MS treatments are introduced, there will be a greater interest in tracking visual function and monitoring for visual comp…

Superficial siderosis of central nervous system mimicking multiple sclerosis.

INTRODUCTION: Superficial siderosis of the central nervous system is a neurologic disorder mainly characterized by cerebellar involvement, myelopathy, neurosensory hearing loss, and possibly progressive cognitive impairment. Root avulsion due to traumatic plexus injury has been recognized as an extremely rare cause of hemosiderin deposition on leptomeninges and subpial layers of brain and spinal cord parenchyma. CASE REPORT: A 49-year-old man presented with progressively evolving ataxia and spastic paraparesis. CSF oligoclonal bands were indicative of an underlying inflammatory process and ra

Fractal dimension analysis of grey matter in multiple sclerosis.

The fractal dimension (FD) is a quantitative parameter that characterizes the morphometric variability of a complex object. Among other applications, FD has been used to identify abnormalities of the human brain in conventional magnetic resonance imaging (MRI), including white matter abnormalities in patients with Multiple Sclerosis (MS). Extensive grey matter (GM) pathology has been recently identified in MS and it appears to be a key factor in long-term disability. The aim of the present work was to assess whether FD measurement of GM in T1 MRI sequences can identify GM abnormalities in pati…

[Optic neuritis in multiple sclerosis: diagnosis and prognosis data].

The most frequent ophthalmologic sign in multiple sclerosis (MS) is optic neuritis (ON), but internuclear ophthalmoplegia, nystagmus, and ocular motor nerve palsies are also observed. This paper describes the most important signs suggesting an inflammatory origin of ON, most particularly MS. We detail new laboratory exams such as optic coherence tomography (OCT), which could be of potential interest for MS patients. Finally, we summarize the prognosis factors for disability in MS after a first episode of ON.

Relationship between psychosocial factors and onset of multiple sclerosis.

OBJECTIVE: The aim of this study was to investigate the influence of psychosocial variables on patients with multiple sclerosis (MS) and the relationship between these variables and the onset of MS. BACKGROUND: The current evidence indicates that many types of psychosocial factors are involved in the development and relapse of MS, and it has been suggested that they could serve as predictors as well. So far, little has been reported on the effect of psychosocial factors on MS and the relationship between psychosocial factors and the onset of MS. METHODS: Forty-one patients, 15 males and 26 f…

[Neuromyelitis optica--an important differential diagnosis for multiple sclerosis].

Neuromyelitis optica (Devic's disease) is a rare autoimmune neuroinflammatory disease. The disease can often be difficult to distinguish from multiple sclerosis. It is important to be familiar with the disease because of the risk of rapid progression to disability or even death. We describe a 15-year-old woman with onset of a typical relapsing-remitting course. The case includes the diagnostic tests and effected treatment.

Multiple sclerosis in the Faroe Islands. 8. Notifiable diseases.

OBJECTIVE: To seek evidence for a possible infectious origin of the type 1 epidemic of multiple sclerosis (MS) in the Faroe Islands. This began in 1943 coincident with their British military occupation throughout World War II. MATERIALS AND METHODS: Data obtained from the Danish National Health Service were assessed for all notifiable diseases in the Faroe Islands reported from 1900 to 1977. RESULTS: Among 38 disorders, selective increases were found for acute infectious gastroenteritis (AIGE) and paradysentery, with outbreaks in late 1940 and in 1943 shortly after the introduction and later…

Paraoxonase 1 activity in different types of multiple sclerosis.

BACKGROUND: Paraoxonase 1 (PON1) is an antioxidant enzyme bound to plasma high-density lipoproteins and is also present in the brain. OBJECTIVE: The aim of this study was to estimate the activity of PON1 in patients with different types of MS. METHODS: The PON1 activity toward paraoxon and phenyl acetate and lipid profile was examined in 40 relapsing-remitting (RR) patients in relapse, in 42 RR patients in remission, in 55 progressive MS patients and in 40 healthy individuals. RESULTS: PON1 activity did not differ in MS patients compared to control group. PON1 activity in relapse was signif