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High mitochondrial sequence divergence in synanthropic flea species (Insecta: Siphonaptera) from Europe and the Mediterranean.

BACKGROUND: Adult fleas are haematophagous ectoparasites of warm-blooded vertebrates, particularly mammals. Among them, the cat flea (Ctenoc … THODS: Fleas were collected in four countries of the Mediterranean Basin (Croatia, Italy, Malta and Israel), as well as in Hungary, from domestic and wild carnivores, rodents and humans. The DNA extracts of representative fleas (n = 148), belonging to ten species of eight genera, were used for PCR amplification of part of their cytochrome c oxidase subun …

Dreaming through wartime: Self-compassion and the echoes of trauma.

OBJECTIVE: This study examines dreaming in the context of prolonged collective trauma. Specifically, it investigates whether exposure to the October 7, 2023, Hamas attacks in Israel, characteristics of dream life, and levels of self-compassion are associated with posttraumatic stress symptoms (PTSS) during the ongoing Israel-Hamas war. METHOD: Participants were 203 Israeli adults (79% women; age range = 21-79 years, M = 38.7), recruited via social media approximately 3 months after the attacks. Dream characteristics were assessed using the Mannheim Dream Questionnaire, which measures both nor…

Accessibility of day-night emergency alert systems for Deaf and hard-of-hearing adults during armed conflict.

BACKGROUND: People with disabilities, including Deaf and hard-of-hearing (DHH) individuals, face disproportionate disaster risks due to communication barriers. Emergency alert systems are predominantly auditory-based, limiting their effectiveness for DHH populations. This gap is especially critical during armed conflict, where timely alerts can be life-saving. OBJECTIVE: This study examined emergency alert system accessibility and associated psychological distress among DHH adults during active armed conflict. METHODS: A cross-sectional online survey was conducted in Israel (October-November…

Triptan Use and Potential Undertreatment in Migraine: A Retrospective Cohort Study.

Background/Objectives: While triptans remain the standard of care for moderate-to-severe migraine, the high discontinuation rates and remarkably low prescribing rates of triptans reflect suboptimal therapeutic optimization. Methods: This retrospective cohort study utilized data from Maccabi Healthcare Services (MHS), the second-largest healthcare provider in Israel, spanning 10 years (2012-2022). We identified naïve triptan users aged 21 years or older and evaluated triptan initiation and discontinuation patterns. Median time to discontinuation was assessed using Kaplan-Meier curves. Results: …

Late-adolescent weight categories and early kidney disease in young adulthood: a nationwide study of Arab and Jewish Israelis.

BACKGROUND: Previous reports have demonstrated that childhood obesity is associated with early chronic kidney disease. The aim of the study was to assess the relationship between weight categories in late adolescence and early chronic kidney disease (CKD) during young adulthood (age 30 years and younger) in individuals of Jewish and Arab ethnicity in Israel, on a nationwide level. METHODS: This retrospective cohort study included 102,902 adolescents aged 17-19 years - 47,892 of Jewish ethnicity and 53,492 of Arab ethnicity, born between 1988 and 1992 and insured by Clalit Health Services. Ear…

Blast injury and chronic psychiatric disability in military personnel: Exploring the association beyond posttraumatic stress disorder.

INTRODUCTION: Blast injuries are common among military personnel, yet their long-term psychiatric consequences, beyond posttraumatic stress … care from 2006 to 2021. Demographics, injury mechanisms, and injury settings were sourced from the Israel Defense Forces Trauma Registry; hospitalization data from the Israeli National Trauma Registry and psychiatric-related disability was assessed utilizing long-term disability claims documented by the Israel Ministry of Health Rehabilitation Departmen …

Patterns of service utilization and its relation to outcome in a first-episode psychosis program.

NAVIGATE is a comprehensive, manual-based intervention developed in the United States for young people experiencing first-episode psychosis (FEP). It comprises four core components: medication management, individual resilience training (IRT), supported employment and education (SEE), and a family psychoeducation program (FEP). This study aimed to describe NAVIGATE utilization patterns in Israel and their relationships to outcomes. Demographic and diagnostic information, service-utilization data, and functioning and symptom ratings were collected from clinical registries of 135 individuals who …

The moderating impact of personal and collective resilience resources on postpartum depression in conflict-affected environments.

BACKGROUND: Women exposed to conflict are at greater risk of experiencing adverse mental health impacts, and women in the postpartum period … parative cross-sectional study included 110 women from regions with high conflict exposure near the Israel-Gaza border and 210 women from areas with lower conflict exposure of Israel. Depression symptoms were evaluated six months postpartum, alongside measures of conflict exposure and personal and collective resilience resources. Multiple linear regressi …

Dissociative and Deep Sedations Administered by Trained Unsupervised Pediatric Residents in Israeli Emergency Departments.

STUDY OBJECTIVE: To cover pediatric emergency physicians' off-hours, third-year pediatric residents in Israel are trained for unsupervised administration of emergency department (ED) dissociative and deep sedation. We assessed the frequency of critical sedation events associated with resident-performed sedations. METHODS: We conducted a retrospective chart review on all patients receiving intravenous sedation across 10 pediatric EDs between January 2018 and September 2022. We defined a critical sedation event as one or more of the following: chest compressions, tracheal intubation, neuromuscu…

Machine learning-based scoring system to predict cardiogenic shock in acute coronary syndrome.

AIMS: Cardiogenic shock (CS) is a severe complication of acute coronary syndrome (ACS) with mortality rates approaching 50%. The ability to … nts hospitalized at intensive care units. Derivation cohort included over 40 000 patients from Beth Israel Deaconess Medical Center, Boston, USA. Validation cohort included 5123 patients from the Sheba Medical Center, Ramat Gan, Israel. The final derivation cohort consisted of 3228 and the final validation cohort of 4904 ACS patients without CS at hospit …

Вирусное нейроинвазивное заболевание Западного Нила: клинические характеристики и прогнозные факторы.

В 2024 году в Израиле произошла самая крупная вспышка вируса Западного Нила (ВНВ), причем 922 случая были подтверждены. WNV является ведущей глобальной причиной вирусного энцефалита. Это исследование было направлено на выявление клинических особенностей и прогнозируемых факторов, связанных с нейроинвазивным ВНВ у госпитализированных пациентов. Мы провели ретроспективную проверку госпитализированных пациентов с подтвержденным WNV в одном из высших центров Израиля (январь-сентябрь 2024 года). Пациенты были отнесены к категории нейроинвазивных или неевроинвазивных. Был проведен анализ демографиче

Совпадение в аннотации оригинала
BACKGROUND: In 2024, Israel experienced its largest West Nile Virus (WNV) outbreak, with 922 confirmed cases. WNV is a leading global cause of viral encephalitis. This study aimed to identify clinical features and prognostic factors associated with neuroinvasive WNV in hospitalized patients. METHODS: We retrospectively reviewed hospitalized patients with co…

The new face of cystic fibrosis in the era of population genetic carrier screening.

BACKGROUND: Population genetic carrier screening (PGCS) for cystic fibrosis (CF) has been offered to couples in Israel since 1999 and was included in a fully subsidized national program in 2008. We evaluated the impact of PGCS on CF incidence, genetic and clinical features. METHODS: This was a retrospective national study. Demographic and clinical characteristics of children with CF born in Israel between 2008 and 2018 were obtained from the national CF registry and from patients' medical records. Data on CF births, preimplantation genetic testing (PGT), pregnancy termination and de-identifie…

A deep look into the storm: Israeli multi-center experience of coronavirus disease 2019 (COVID-19) in patients with autoimmune inflammatory rheumatic diseases before and after vaccinations.

OBJECTIVE: We aimed to characterize the course of COVID-19 in autoimmune inflammatory rheumatic disease (AIIRD) patients in Israel, taking into consideration several remarkable aspects, including the outcomes of the different outbreaks, the effect of vaccination campaigns, and AIIRD activity post-recovery. METHODS: We established a national registry of AIIRD patients diagnosed with COVID-19, including demographic data, AIIRD diagnosis, duration and systemic involvement, comorbidities, date of COVID-19 diagnosis, clinical course, and dates of vaccinations. COVID-19 was diagnosed by a positive …

Licensed Medical Cannabis Use in Gilles de la Tourette Syndrome: A Retrospective Long-term Follow-Up.

Background: Medical cannabis (MC) is widely used in clinical practice to treat Gilles de la Tourette syndrome (GTS). However, legislation, multiple modes of administration, and inconsistent plant preparations have limited trials to assess its benefits and long-term safety. For the past decade, licensed MC has been authorized in Israel for use in resistant GTS. We aimed to describe subjects' satisfaction, consumption habits, and THC dose increment during long-term usage. Materials and Methods: A retrospective longitudinal data collection (up to 9 years) on cannabis use habits and structured que…

Furosemide Responsiveness Predicts Acute Kidney Injury Progression After Cardiac Surgery.

BACKGROUND: As patients with acute kidney injury (AKI) progress to a higher stage, the risk for poor outcomes dramatically rises. Early identification of patients at high risk for AKI progression remains a major challenge. This study aimed to evaluate the value of furosemide responsiveness (FR) for predicting AKI progression in patients with initial mild and moderate AKI after cardiac surgery. METHODS: We performed 2 separate exploratory analyses. The Zhongshan cohort was a single-center, prospective, observational cohort, whereas the Beth Israel Deaconess Medical Center cohort was a single-c…

Distress among hospitalized patients with acute coronary syndrome.

BACKGROUND: Previous studies have demonstrated that those suffering from acute coronary syndrome (ACS) experience various physical and psych … N: The study conducted a descriptive, cross-sectional survey. METHODS: The Acute Coronary Syndrome Israel Study is a national, biennial registry, enrolling all patients with ACS admitted to cardiac intensive care or cardiology wards in Israel within a 2-month period. Demographic and clinical data were retrieved from an electronic database. Distress was …

The Yield of Targeted Examination for the Detection of Symptomatic Congenital Cytomegalovirus Infection.

BACKGROUND: The incidence of congenital cytomegalovirus (CMV) infection in Israel is 0.7%. Only 10-15% are symptomatic. Valganciclovir has been shown to improve hearing and neurodevelopmental outcomes in neonates with symptomatic congenital CMV infection. Targeted examination of infants who fail routine neonatal hearing screening or have clinical or laboratory findings suggestive of symptomatic congenital CMV infection may be a cost-effective approach. OBJECTIVES: To assess the possibility of targeted examination for the detection of newborns with symptomatic congenital CMV infection. METHOD…

Bedouin Children With Celiac Disease: Less Symptoms but More Severe Histological Features at Presentation.

Background: The prevalence of celiac disease (CD) has dramatically increased with wide variability in clinical presentations between different geographical areas. However, the contribution of ethnic disparities in pediatric celiac disease is still unclear, especially in patients of Bedouin origin. Objective: We aimed to compare the clinical presentation and histological severity of celiac disease between Bedouin and Jewish children in southern Israel. Methods: This is a retrospective study in which we collected the demographic and clinical data, laboratory results, and histological severity of…

An Intraprocedural Endoscopic Cleansing Device for Achieving Adequate Colon Preparation in Poorly Prepped Patients.

BACKGROUND AND AIMS: An effective bowel preparation is essential for quality colonoscopy. Inadequate preparation results in missed lesions, need for earlier repeat procedures, prolonged colonoscopy duration, an increased likelihood of adverse events, reduced patient satisfaction, and increased costs. The MOTUS GI Pure-Vu System (Tirat Carmel, Israel) is an Food and Drug Administration-cleared device designed to improve visualization in an inadequately prepared colon by facilitating intraprocedural cleaning. We evaluated the efficacy, safety, and usability of the Pure-Vu System in cleansing poo…

NOD2/CARD15 Mutations among Bedouin Arabs with Inflammatory Bowel Disease: Frequency and Phenotype Correlation.

BACKGROUND: Inflammatory bowel disease (IBD) prevalence is increasing among Bedouin Arabs in Israel. This population is known to have a high rate of consanguinity. NOD2/CARD15 mutations are well-studied in IBD. OBJECTIVES: To investigate the frequency of NOD2/CARD15 mutations in IBD Bedouin patients and their relevance to disease phenotype. METHODS: The IBD-Arab cohort in southern Israel included 68 patients, of which 25 Crohn's disease (CD) patients and 25 ulcerative colitis (UC) patients consented to participate (72%). Blood samples were obtained from all participants who were genotyped fo…