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Slow versus rapid enteral feeding advancement in preterm newborn infants 1000-1499 g: a randomized controlled trial.

AIM: To evaluate whether preterm neonates weighing 1000-1499 g at birth receiving rapid enteral feeding advancement at 30 mL/kg/day attain full feedings (180 mL/kg/day) earlier than those receiving slow enteral feeding advancement at 20 mL/kg/day without increase in the incidence of feeding intolerance or necrotizing enterocolitis. METHODS: A total of 100 stable intramural neonates weighing between 1000 and 1499 g and gestational age less than 34 weeks were randomly allocated to enteral feeding (expressed human milk or formula) advancement of 20 mL/kg/day (n = 50) or 30 mL/kg/day (n = 50). R

Improving head growth in very preterm infants--a randomised controlled trial I: neonatal outcomes.

BACKGROUND: Infants born very preterm are at an increased risk of poor growth in the post-natal period. Poor brain growth in this critical period may result from inadequate nutrition, and has long-term effects on neurodevelopmental outcome. AIMS: To examine the feasibility of providing macronutrients at amounts above current recommendations (hyperalimentation) to improve nutrition and head growth in preterm infants. METHODS: 142 infants <29 weeks' gestation were randomised to hyperalimented or standard parenteral and enteral nutrition. Growth was monitored from birth to 36 weeks' postmenstru

Genotypic and Phenotypic Characterization of Cronobacter spp. Strains Isolated from Powdered Milk Formulas and Dairy Production Environments.

Cronobacter spp. is a pathogenic genus comprising seven species, of which C. sakazakii is particularly notable for its association with neonatal outbreaks linked to powdered infant formula. The severity of infections is associated with virulence factors (VFs) and β-lactam antibiotic resistance genes (ARGs). Next-generation sequencing (NGS) has enabled precise strain typing through core genome multilocus sequence typing (cgMLST), enhancing discrimination and accuracy. This study aimed to use cgMLST (2831 genes) to genomically characterize 34 Cronobacter strains which had been isolated from powd…

Integrated lipidomics and fatty acid positional distribution for nutritional assessment of nine mammalian milks.

The nutritional value of milk fat depends on lipid and fatty acid composition. This study characterized the lipidomics and fatty acid positi … These findings provide a systematic reference for evaluating mammalian milks and data for humanized infant formula lipid design.

Infantile extreme hypertriglyceridemia diagnosed as glycogen storage disease type Ia: A case report.

RATIONALE: Glycogen storage disease type Ia (GSD Ia) typically presents with fasting hypoglycemia and hyperlipidemia. Atypical infantile presentations can delay diagnosis. We report an infant with extreme hypertriglyceridemia ultimately diagnosed as GSD Ia. PATIENT CONCERNS: A 5-month-old girl presented with poor appetite, growth retardation, hepatomegaly, and extreme hypertriglyceridemia (72 mmol/L), hypercholesterolemia, elevated transaminases, hyperuricemia, and hyperlactatemia, but initial normal blood glucose. DIAGNOSES: Initial differentials included familial hypertriglyceridemia, but

Human Bone Marrow-Derived Mesenchymal Stromal Cells Reduce the Severity of Experimental Necrotizing Enterocolitis in a Concentration-Dependent Manner.

Necrotizing enterocolitis (NEC) is a devastating gut disease in preterm neonates. In NEC animal models, mesenchymal stromal cells (MSCs) administration has reduced the incidence and severity of NEC. We developed and characterized a novel mouse model of NEC to evaluate the effect of human bone marrow-derived MSCs (hBM-MSCs) in tissue regeneration and epithelial gut repair. NEC was induced in C57BL/6 mouse pups at postnatal days (PND) 3-6 by (A) gavage feeding term infant formula, (B) hypoxia/hypothermia, and (C) lipopolysaccharide. Intraperitoneal injections of PBS or two hBM-MSCs doses (0.5 × …

Concentrations, influencing factors, risk assessment methods, health hazards and analyses of polycyclic aromatic hydrocarbons in dairies: a review.

The occurrence of polycyclic aromatic hydrocarbons (PAHs) in dairies has been widely reported. Consumers may be overly exposed to PAHs throu … torage. There was a significant correlation between fat contents and PAH concentrations. Results of infant formula in certain research were worrying and those of smoked cheeses are remarkably high indicating the dangerous smoking process. It is significant to monitor PAHs and calculate TEQBaP from meadows to feeders. Moreover, the existing regulations are insuff …

The Effects of Early Life Stress, Postnatal Diet Modulation, and Long-Term Western-Style Diet on Later-Life Metabolic and Cognitive Outcomes.

Early life stress (ES) increases the risk to develop metabolic and brain disorders in adulthood. Breastfeeding (exclusivity and duration) is associated with improved metabolic and neurocognitive health outcomes, and the physical properties of the dietary lipids may contribute to this. Here, we tested whether early life exposure to dietary lipids mimicking some physical characteristics of breastmilk (i.e., large, phospholipid-coated lipid droplets; Concept Nuturis® infant milk formula (N-IMF)), could protect against ES-induced metabolic and brain abnormalities under standard circumstances, and

Breastfeeding and childhood obesity: A 12-country study.

This study aimed to examine the association between breastfeeding and childhood obesity. A multinational cross-sectional study of 4,740 children aged 9-11 years was conducted from 12 countries. Infant breastfeeding was recalled by parents or legal guardians. Height, weight, waist circumference, and body fat were obtained using standardized methods. The overall prevalence of obesity, central obesity, and high body fat were 12.3%, 9.9%, and 8.1%, respectively. After adjustment for maternal age at delivery, body mass index (BMI), highest maternal education, history of gestational diabetes, gestat

A new metabolic disorder in human cationic amino acid transporter-2 that mimics arginase 1 deficiency in newborn screening.

PURPOSE: We report a patient with a human cationic amino acid transporter 2 (CAT-2) defect discovered due to a suspected arginase 1 deficien … ntly, the child receives a protein-controlled diet of 1.2 g/kg/day with protein-and amino-acid free infant formula, 30 g/day, and is asymptomatic. CONCLUSION: We identified a novel defect in human CAT-2 due to biallelic pathogenic variants in the SLC7A2 gene. The characteristic biochemical profile includes high plasma and urine arginine, ornithine, and lysine l …

Effect of technological treatments on bovine lactoferrin: An overview.

Lactoferrin (LF) is a multifunctional protein that exerts important activities in the neonate through its presence in milk, and also in other external mucosas, acting as a defense protein of innate immunity. The addition of bovine LF to infant formula and also to other functional products and cosmetics has increased during the last decades. Consequently, it is essential to know the effect that the technological processes, necessary to elaborate those products, have on LF activity. In this study, we have revised the effect of classical treatments on lactoferrin structure and activity, such as h…

[Severe rhabdomyolysis secondary to severe hypernatraemic dehydration].

INTRODUCTION: Rhabdomyolysis is a rare paediatric condition. The case is presented of a patient in whom this developed secondary to severe hypernatraemic dehydration following acute diarrhoea. CASE REPORT: Infant 11 months of age who presented with vomiting, fever, diarrhoea and anuria for 15 hours. Parents reported adequate preparation of artificial formula and oral rehydration solution. He was admitted with malaise, severe dehydration signs and symptoms, cyanosis, and low reactivity. The laboratory tests highlighted severe metabolic acidosis, hypernatraemia and pre-renal kidney failure (Sod

The pros and cons of phytoestrogens.

Phytoestrogens are plant derived compounds found in a wide variety of foods, most notably soy. A litany of health benefits including a lower … etary supplements and widely marketed as a natural alternative to estrogen replacement therapy. Soy infant formula now constitutes up to a third of the US market, and soy protein is now added to many processed foods. As weak estrogen agonists/antagonists with molecular and cellular properties similar to synthetic endocrine disruptors such as Bisphenol A (BPA), t …

[Isolation of Shiga-toxin-producing Escherichia coli strains during a gastrointestinal outbreak at a day care center in Mar del Plata City].

From October 15 to November 8, 2003, a gastrointestinal outbreak occurred at a day care center in a Hospital in Mar del Plata City. Fourteen out of 80 (17.5%) children, mean age 23.6 +/- 13.9 months, and the mother of one of them had diarrhea. One case developed hemolytic uremic syndrome. No conclusive evidence of the origin of the outbreak was found, but the epidemic curve suggested person-to-person spread. The usual practices at the place where infant milk formula was prepared at the day care center, together with the inadequate infrastructure conditions and hygiene practices at the kitchen

Protein-energy malnutrition--its epidemiology and control.

The four most important deficiency diseases in developing countries today are protein-energy malnutrition (PEM), xerophthalmia, nutritional … em of malnutrition in nonindustrialized countries. The decline in breast-feeding and greater use of infant formula provide a good example of this problem. Finally, economic improvement in the Third World is essential if PEM is to be greatly reduced.

Intragastric feeding in type I glycogen storage disease: factors affecting the control of lactic acidemia.

Continuous nocturnal intragastric feeding, combined with frequent daytime feedings, has been reported to improve both linear growth and the … her reduction of blood lactate. At identical rates of glucose administration, a dextrose-containing infant formula and a high carbohydrate enteric feeding solution gave no significant improvement in control of blood lactate levels compared to dextrose alone. Plasma glucose levels fell more rapidly when intragastric feeding was stopped than after a mixed meal and …

Deciphering Cronobacter sakazakii Pathogenesis: From Host Invasion to Future Directions.

Cronobacter sakazakii is a formidable foodborne pathogen that poses a severe, often fatal threat to neonates and immunocompromised individuals, with contaminated powdered infant formula as the primary transmission vehicle. Infections can lead to devastating conditions, such as meningitis, necrotizing enterocolitis, and sepsis, with alarmingly high mortality rates. Clinical management is hampered by the lack of standardized treatment guidelines and the emergence of antibiotic resistance. However, ongoing research into its molecular pathogenesis continually covers novel targets for intervention.…

Электрохимический биосенсор на основе фюзеляжа для быстрого обнаружения кронобактера в пище.

Cronobacter spp. является высокоопасным пищевым патогеном, который представляет серьезную угрозу для новорожденных. Она может вызывать серьезные инвазивные инфекции, такие, как менингит и некротизирующий энтеноколит, причем коэффициент смертности составляет до 80%. Поэтому разработка быстрых и точных методов обнаружения имеет решающее значение для эффективного предупреждения и борьбы с инфекциями, вызываемыми спектером Кронобактера. В этом исследовании представлен инновационный электрохимический биосенсор, основанный на белке фисташкового волокна, полученном из фисташкового волокна (TFP08), дл

Совпадение в аннотации оригинала
Cronobacter spp. is a high-risk foodborne pathogen that poses a significant threat to neonates. It can cause severe invasive infections such … 2.3 × 101 to 3.7 × 107 CFU/mL, with a limit of detection as low as 23 CFU/mL. When tested in spiked infant formula and lettuce samples, the biosensor exhibited excellent recovery rates (99.23-102.46%) and high reproducibility (relative standard deviation ≤1.17%), This demonstrates its reliability and accuracy in complex food matrices. This work presents a rapid …

Maternal exposure to purified versus grain-based diet during early lactation in mice affects offspring growth and reduces responsivity to Western-style diet challenge in adulthood.

The nutritional environment during fetal and early postnatal life has a long-term impact on growth, development, and metabolic health of the offspring, a process termed "nutritional programming." Rodent models studying programming effects of nutritional interventions use either purified or grain-based rodent diets as background diets. However, the impact of these diets on phenotypic outcomes in these models has not been comprehensively investigated. We used a previously validated (C57BL/6J) mouse model to investigate the effects of infant milk formula (IMF) interventions on nutritional program

The value of MMP-7 combined with serological markers in diagnosing liver fibrosis in children with biliary atresia.

OBJECTIVE: To explore the diagnostic value of Matrix Metallopeptidase 7 (MMP-7) alongside serological markers in identifying liver fibrosis in children with biliary atresia (BA). METHODS: A retrospective study was conducted to analyze the general information, liver fibrosis stage, and laboratory results, including MMP-7, of children with BA who underwent Kasai portoenterostomy between 2022 and 2024 at two Chinese hospitals. The aspartate aminotransferase to platelet ratio index (APRI), Fibrosis 4 Score (FIB-4), and infant biliary atresia liver fibrosis (iBALF) score were calculated according t