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Specific mode acupoint electrical stimulation combined with NGF for neurological recovery in ischemic stroke convalescence: A randomized controlled study.

BACKGROUND: Nerve growth factor (NGF) has neurorestorative potential after ischemic stroke, but its efficacy may be limited by the blood-brain barrier (BBB). Preclinical studies suggested that specific mode acupoint electrical stimulation (SMES) may transiently increase BBB permeability and facilitate neurotrophic factor delivery. This study evaluated the efficacy and safety of SMES combined with NGF in ischemic stroke and explored treatment-associated functional brain changes. METHODS: In this multicentre, randomized, placebo-controlled trial, adults aged 30-80 years with first-ever ischemic

Дифференциация силы сигнала МРТ по мозговому энцефалиту, вызванному Enterovirus 71: классификационный подход к этапам острой и выздоравливания.

Цель настоящего исследования состоит в том, чтобы оценить стандартизированные гистограммы силы сигнала T1 и T2 на сагиттальном виде без улучшения на 1) острой стадии и 2) стадии выздоравливания педиатрических пациентов с энцефалитом мозга 71, связанным с энцефалитом головного мозга (BE), и в отношении (3) здоровых норм. МЕТОДЫ: Наши подданные были госпитализированы в период с марта 2010 года по октябрь 2012 года и прошли подготовку до и после проведения МРТ. Необходимо ответить на вопрос о том, может ли сопоставление гистограмм интенсивности изображений МРТ и соответствующей статистической кол

Совпадение в аннотации оригинала
BACKGROUND: The objective of this study is to assess standardized histograms of signal intensities of T1 signal and T2 signal on sagittal view without enhancement during (1) acute stage, and (2) convalescence stage of pediatric patients with Enterovirus 71 related brainstem encephalitis (BE), and with respect to (3) healthy normal. METHODS: Our subjects wer…

Convalescent Spontaneous Coronary Artery Dissection With Elevated Pericoronary Fat Attenuation Index.

BACKGROUND: Myocardial infarction with nonobstructive coronary arteries (MINOCA) is defined by the presence of the universal acute myocardial infarction criteria in the absence of obstructive disease on angiography. Multimodal imaging can be invaluable in determining the underlying etiology of MINOCA. Spontaneous coronary artery dissection (SCAD) is among the most common etiologies. CASE SUMMARY: This report describes a case of unrecognized/asymptomatic myocardial infarction due to SCAD in an active 62-year-old woman whose care was facilitated by comprehensive evaluation of MINOCA. DISCUSSIO

Alterations of thyroid and adipose tissue hormones in acute and convalescent COVID-19 patients.

OBJECTIVE: Aim: To study and analyze studies data of thyroid function and adipose tissue hormones changes in patients with coronavirus infection. PATIENTS AND METHODS: Materials and Methods: The study was conducted on the basis of the Clinical Hospital «CMCH», Uzhhorod, outpatient department. The clinical presentation of the patients with Covid-19 verified diagnosis of was represented by damage to the upper respiratory tract, in particular nasopharyngitis. The age of the studied patients was 18±2.15 years. RESULTS: Results: All thyroid status parameters varied within the reference values, bu

Variations in oral health outcomes and mycobiome composition among COVID-19 convalescents.

The link between gut microbiota and COVID-19 has been previously established, but the role of the oral fungal microbiota in this context remains underexplored. This study aimed to characterize the oral mycobiome of COVID-19 convalescents. Saliva samples were collected from three groups: COVID-19 patients treated with antibiotics (group I), COVID-19 patients without antimicrobial treatment (group II), and healthy volunteers (group III) from the University Hospital and from the University Dental Clinic in Kraków. The samples were analyzed using next-generation sequencing (NGS) targeting the ITS-

Convalescent plasma for COVID-19: planning for the next pandemic using the worldwide experience.

SUMMARYCOVID-19 convalescent plasma (CCP) was the first specific therapy deployed for treating SARS-CoV-2 infection. CCP was successfully deployed in both resource-poor and resource-rich countries, establishing that convalescent plasma (CP) is a feasible option for combating the next pandemic. CCP reduced mortality and progression to hospitalization when used early in the disease with high-titer units. This knowledge was gained from a worldwide effort that included more than 50 countries. However, the deployment of CCP was haphazard and varied among countries. Clinical studies suffered from a

Convalescent plasma for the treatment of patients with COVID-19: the Singapore experience and lessons learnt.

INTRODUCTION: We report Singapore's convalescent plasma (CP) programme during the first year of the COVID-19 pandemic. Based on historical data and its potential therapeutic promise, CP was offered as an experimental treatment option for severe or high-risk COVID-19 patients when established therapeutics were lacking. METHODS: The CP programme was implemented under monitored expanded access approved by Singapore's Ministry of Health. CP donors were primarily selected based on specific antibody titres, while suitable recipients were chosen based on risk factors and disease severity. Operationa

Treatment with Sulodexide Downregulates Biomarkers for Endothelial Dysfunction in Convalescent COVID-19 Patients.

INTRODUCTION: Persistent elevation of biomarkers associated with endothelial dysfunction in convalescent COVID-19 patients has been linked t … ide (250 LRU orally, twice daily) with placebo over 8 weeks in adult patients during early COVID-19 convalescence. Differences in serum biomarkers between the groups were analyzed using repeated measures and post hoc tests, with Thrombomodulin (TM) as the primary endpoint. RESULTS: Among 206 analyzed patients (103 in each group), at week 8, the sulodexide grou …

Treatment of chronic COVID-19 with convalescent/postvaccination plasma in patients with hematologic malignancies.

Immunocompromised patients are at high risk to fail clearance of SARS-CoV-2. Prolonged COVID-19 constitutes a health risk and a management problem as cancer treatments often have to be disrupted. As SARS-CoV-2 evolves, new variants of concern have emerged that evade available monoclonal antibodies. Moreover, antiviral therapy promotes SARS-CoV-2 escape mutations, particularly in immunocompromised patients. These patients frequently suffer from prolonged infection. No successful treatment has been established for persistent COVID-19 infection. Here, we report on a series of 21 immunocompromised

Impact of Hospital Dentistry on Patients' Food Intake Status in Convalescent Rehabilitation Ward.

BACKGROUND: Treating oral problems with dentist intervention during hospitalisation may improve patients' food intake status. OBJECTIVES: This study aimed to clarify whether convalescent rehabilitation ward inpatients in a hospital with hospital dentistry (HHD) had a better diet at discharge than those in a hospital without hospital dentistry (HNHD). METHODS: Retrospective observational study including inpatients with dental involvement in a HHD with dentists and dental hygienists and HNHD with dental hygienist and visiting dental service between 1 March and 31 August 2022. Data included age

Comparing Bacillus Calmette-Guérin (BCG) strains in convalescent COVID-19 patients.

Aim: We previously published results of the BATTLE trial, showing that patients recently infected with SARS-CoV-2 can benefit from receiving Bacillus Calmette-Guérin (BCG) with minimal adverse effects. The study incorporated two strains of this vaccine. In this study, patient outcomes were compared based on the strain of BCG because different strains have been shown to have different immunogenicity. Methods: BATTLE was a double-blind controlled trial of COVID-19 convalescent patients; symptom progression, injection-site lesion characteristics and adverse effects were compared between recipient

Immunological fingerprint in coronavirus disease-19 convalescents with and without post-COVID syndrome.

BACKGROUND: Symptoms lasting longer than 12  weeks after severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection are called post-coronavirus disease (COVID) syndrome (PCS). The identification of new biomarkers that predict the occurrence or course of PCS in terms of a post-viral syndrome is vital. T-cell dysfunction, cytokine imbalance, and impaired autoimmunity have been reported in PCS. Nevertheless, there is still a lack of conclusive information on the underlying mechanisms due to, among other things, a lack of controlled study designs. METHODS: Here, we conducted a pr

Convalescent Adaptive Immunity Is Highly Heterogenous after SARS-CoV-2 Infection.

The optimal detection strategies for effective convalescent immunity after SARS-CoV-2 infection and vaccination remain unclear. The objective of this study was to characterize convalescent immunity targeting the SARS-CoV-2 spike protein using a multiparametric approach. At the beginning of the pandemic, we recruited 30 unvaccinated convalescent donors who had previously been infected with COVID-19 and 7 unexposed asymptomatic controls. Peripheral blood mononuclear cells (PBMCs) were obtained from leukapheresis cones. The humoral immune response was assessed by measuring serum anti-SARS-CoV-2 s

Guidance on the Use of Convalescent Plasma to Treat Immunocompromised Patients With Coronavirus Disease 2019.

Coronavirus disease 2019 (COVID-19) convalescent plasma (CCP) is a safe and effective treatment for COVID-19 in immunocompromised (IC) patients. IC patients have a higher risk of persistent infection, severe disease, and death from COVID-19. Despite the continued clinical use of CCP to treat IC patients, the optimal dose, frequency/schedule, and duration of CCP treatment has yet to be determined, and related best practices guidelines are lacking. A group of individuals with expertise spanning infectious diseases, virology and transfusion medicine was assembled to render an expert opinion state

Anticholinergic Load Is Associated with Swallowing Dysfunction in Convalescent Older Patients after a Stroke.

This study aimed to establish whether anticholinergic load affects the swallowing function of geriatric stroke patients in convalescent stages, as no proven association between the anticholinergic load-based Anticholinergic Risk Scale and the swallowing dysfunction in Japanese patients was known. A retrospective cohort study was conducted on hospitalized older patients undergoing rehabilitation after stroke. The study outcomes included evaluating the patients at hospital discharge using the Functional Oral Intake Scale. To evaluate the effects of an increased anticholinergic load, we used a mu

'Convalescent Plasma'- An Effective Treatment Option to Prevent Emerging nCOVID-19- A Review.

To date, no accepted therapy exists for treating the emerging infectious disease nCOVID-19 in a safe and effective way. Although various treatment options are under in the developing phase around the world, several studies concerning convalescent plasma (CP) from recovered patients reported promising effects against nCOVID-19 infected critically ill patients nowadays. The therapy showed very few adverse effects, and it helps diminish the viral load when administered at an early stage of infection. Convalescent plasma appears safe for critically ill nCOVID-19 patients by decreasing serum viral

Convalescent plasma therapy for patients with severe COVID-19: A case series study.

Coronavirus disease 2019 (COVID-19) is a novel acute respiratory infectious disease that can lead to multiple-organ dysfunction in patients with severe disease. However, there is a lack of effective antiviral drugs for COVID-19. Herein, we investigated the efficacy and safety of convalescent plasma (CP) therapy for treating severe COVID-19 in an attempt to explore new therapeutic methods. The clinical data of 3 imported patients with severe COVID-19 who underwent treatment with CP and who were quarantined and treated in a designated COVID-19 hospital from March 2020 to April 2020 were collecte

Characterization of an Anti-Ebola Virus Hyperimmune Globulin Derived From Convalescent Plasma.

BACKGROUND: Convalescent plasma has been used to treat many viral diseases including Ebola. The manufacture of a purified anti-Ebola virus (EBOV) intravenous immunoglobulin (IVIG) from pooled convalescent plasma is described in this paper. METHODS: An enzyme-linked immunosorbent assay (ELISA) targeting an EBOV surface glycoprotein antigen was used to determine the immunoglobulin titer of pooled plasma and purified anti-EBOV IVIG. Anti-EBOV IVIG was also tested in neutralization assays using a vesicular stomatitis virus pseudovirion expressing EBOV glycoprotein on its surface and with live EBO

Coronavirus disease 2019 convalescent children: outcomes after congenital heart surgery.

BACKGROUND: Children with exposure to coronavirus disease 2019 in recent times (asymptomatic or symptomatic infection) approaching congenita … One thousand one hundred and twenty-nine consecutive congenital heart surgeries were stratified as convalescence and control. Coronavirus disease 2019 Convalescent (n = 349) and coronavirus disease 2019 control (n = 780) groups were comparable for all demographic and clinical factors except younger and smaller kids in control. Convalescent children had no high …