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Patterns of cortical atrophy are associated with specific cognitive domains in patients with logopenic primary progressive aphasia.

BackgroundLogopenic primary progressive aphasia (LPA) is often associated with Alzheimer's disease (AD) pathology. However, few studies have … ins.ResultsThe LPA group performed significantly worse than the aMCI group on NP measures assessing verbal learning, attention/working memory, language, and executive functioning (p < 0.05). Compared to the aMCI group, the LPA group demonstrated both smaller and thinner cortex in the left lateral aspect of the superior temporal gyrus, superior temporal sulcus, an …

The impact of music-based intervention on cognitive function and brain functional magnetic resonance imaging in people with mild Alzheimer's disease.

BackgroundWith the accelerating global aging population, the incidence of Alzheimer's disease (AD) continues to rise, while current pharmaco … rd Fluency Test (WFT), World Health Organization-University of California, the Los Angeles Auditory Verbal Learning Test (WHO-UCLA-AVLT), and functional magnetic resonance imaging (fMRI). Data were analyzed using SPSS 20.0.Results47 participants completed the study. The music-based intervention group showed significant improvements in MoCA, GDS, NPI, WFT, and WHO …

Visual Working Memory in Pediatric Epilepsy using Magnetoencephalography: Pilot Study.

Pediatric epilepsy is known to impair behavior, cognition, and learning, particularly affecting working memory (WM). While many aspects of verbal WM have been studied in pediatric epilepsy, little is known about visuospatial working memory (VSWM). VSWM is crucial for spatial navigation, object recognition, and early literacy skills, aiding children in recalling shapes, colors, positions, and movements. Magnetoen-cephalography (MEG), a non-invasive neuroimaging technique with high temporal resolution, provides direct insight into the neural disruptions of VSWM. To investigate this, we measured

Caudate nucleus atrophy as a neuroimaging feature of mild cognitive impairment induced by occupational aluminum exposure.

Occupational aluminum (Al) exposure is linked to mild cognitive impairment (MCI), yet its neuroanatomical mechanisms remain unclear. We investigated gray matter volume (GMV) alterations specifically associated with Al-induced MCI. This study enrolled 86 participants: 30 Al-exposed MCI (Al-MCI), 26 Al-exposed cognitively normal (Al-HC), and 30 non-exposed controls (Non-Al-HC). Structural MRI quantified whole-brain GMV. Plasma Al concentrations, Montreal Cognitive Assessment (MoCA), the Rey Auditory Verbal Learning Test (AVLT), and the Trail Making Test (TMT) were assessed in Al-exposed individu…

Optimizing Student Outcomes: A Comparison of Two Teaching Methods for Identifying Vegetal Foreign Bodies in Canine Limbs Using Simulation Models and Ultrasound.

Musculoskeletal ultrasonography is an underutilized skill within the veterinary industry. It requires practice and repetition to improve confidence and competence. In a clinic, ultrasonography is often used to identify grass seeds in patients; however, its teaching within the veterinary curriculum is limited. This study investigated the use of simulation models using two different teaching methods to improve undergraduate student outcomes in identifying vegetal foreign bodies (VFB). Forelimb models, containing wild oaten grass seeds (Avena fatua) in one of three locations, were used as ultraso

Сравнительное исследование когнитивного расстройства в эпизодических и семейных случаях множественного склероза.

Генетика играет важную роль в многоразовом склерозе (MS), причем примерно 12,6% случаев происходят в семейной форме. Хотя предыдущие исследования показали различия в динамике заболеваний и результатах МРТ между семейными и спорадическими МЗ, сопоставления когнитивных нарушений между ними не проводилось. В этом исследовании мы оценивали когнитивные показатели у пациентов с спорадическим и семейным MS, а также у здоровой контрольной группы. В общей сложности для каждой группы было набрано 130 человек, соответствующих их возрасту, полу и уровню образования. Средний возраст участников составлял 37

Совпадение в аннотации оригинала
Genetics plays a significant role in Multiple Sclerosis (MS), with approximately 12.6% of cases occurring in familial form. While previous s … s Test (SDMT) (Familial: 46.96 ± 12.59, Sporadic: 45.88 ± 14.13, Normal: 56.48 ± 11.89), California Verbal Learning Test (CVLT) (Familial: 66.90 ± 14.01, Sporadic: 68.19 ± 16.49, Normal: 75.18 ± 13.02), and the Brief Visuospatial Memory Test-Revised (BVMT-R) (Familial: 24 (12), Sporadic: 24 (12), Normal: 35 (4)) compared to healthy controls. Meanwhile, no signifi …

Существует ли пороговая или зависимость &quot; доза-реакция &quot; между физической активностью и когнитивной функцией при множественном склерозе?

ЦЕЛЬ: Когнитивное расстройство широко распространено, недействителен и плохо регулируется при множественном склерозе (МС). Физическая активность, зачастую выраженная в виде шагов в день, связана с когнитивной функцией этой группы населения. В этом кратком докладе рассматривается возможность установления 1) порогового показателя в день, связанного с отсутствием когнитивного расстройства, или 2) соотношения &quot; доза-реакция &quot; между ступенями в день и когнитивной функцией в MS. МЕТОД: В выборке приняли участие 358 человек, имеющих MS, которые представили демографическую (возраст, пол, рас

Совпадение в аннотации оригинала
OBJECTIVE: Cognitive impairment is prevalent, disabling, and poorly managed in multiple sclerosis (MS). Physical activity, often expressed a … isability status) information, and completed the Symbol Digit Modalities Test (SDMT) and California Verbal Learning Test-Second Edition (CVLT-II). Participants wore an ActiGraph GT3X+ accelerometer above the non-dominant hip during waking hours of the day over a 7-day period for measuring steps/day. RESULTS: The receiver operating characteristic (ROC) curve anal …

Diagnosing Suicidal Ideation from Resting State EEG Data Using a Machine Learning Algorithm.

Suicide poses a global health crisis with significant social and economic impact. Prevention may be possible if objective quantitative methods are developed to supplement the often inaccurate interview-based risk assessments. Our research goal is to develop a machine learning algorithm (MLA) to predict the presence of suicide ideation from resting state electroencephalography (EEG) data collected from 224 subjects with major depressive disorder (MDD) in the Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care for Depression (EMBARC) study. Using the Concise He

Predicting the reversion from mild cognitive impairment to normal cognition based on magnetic resonance imaging, clinical, and neuropsychological examinations.

BACKGROUND: Reversion from mild cognitive impairment (MCI) to normal cognition (NC) is not uncommon and indicates a better cognitive traject … ion, hippocampus volume, the Alzheimer's Disease Assessment Scale-Cognitive score, the Rey Auditory Verbal Learning Test-immediate score, and mean arterial pressure) achieved good C-indexes of 0.892 (95 % confidence interval [CI], 0.859-0.926) and 0.806 (95 % CI, 0.709-0.902) for the training and validation cohort. LIMITATION: Observational duration is relativel …

Associations Between Cognitive Impairment and Neuroimaging in Patients with Multiple Sclerosis.

OBJECTIVE: Multiple sclerosis (MS) is a debilitating inflammatory and neurodegenerative disease which commonly involves cognitive dysfunctio … ol Digit Modalities Test (β = 0.11), Brief Visuospatial Memory Test, delayed (β = 0.12), California Verbal Learning Test, delayed and total (β = 0.24 and β = 0.15 respectively), and Trail Making Test Part A (β = -0.01), after adjusting for covariates. CONCLUSIONS: These findings demonstrate an independent association between thalamic volumes and processing speed …

Cortico-limbic volume abnormalities in late life depression are distinct from β amyloid and white matter pathologies.

This study was conducted to clarify patterns of cortico-limbic volume abnormalities in late life depression (LLD) relative to non-depressed … 0.03 to 0.15]). LLD exhibited poorer performance on measures of global cognition, set shifting, and verbal learning and memory relative to ND. Cognitive function was positively associated with cortico-limbic volumes and these relationships did not differ by group. Secondary analyses with an ND sample additionally matched for Mild Cognitive Impairment (MCI) diagno …

Effect of traumatic upper-limb injury on cognitive functions: A cross-sectional observational study.

OBJECTIVES: There is growing evidence of cognitive impairment after traumatic peripheral lesions. The purpose of this study was to explore t … and occupation. Short-term memory and executive functions were assessed using the Rey Auditory and Verbal Learning Test (RAVLT) and Stroop Color and Word Test (SCWT), respectively. RESULTS: 104 participants with traumatic upper-limb injury and 104 uninjured control subjects were included. There was a significant inter-group difference only in RAVLT (p < 0.01; C …

Childhood trauma and cognitive functioning in mood disorders: A systematic review.

BACKGROUND: Cognitive impairment is a core feature of mood disorders and has been identified as an important treatment target. A better unde … s for euthymic patients and psychomotor speed for in-episode patients. There was mixed evidence for verbal learning and memory and executive function for in-episode patients. Identification of patterns within other domains was difficult due to limited number of studies. CONCLUSION: Findings from this review suggest childhood trauma is associated with poorer cogn …

Hidden hurt: A qualitative study of the microaggressions experienced by disabled children in education in China.

BACKGROUND: Microaggressions are brief, commonplace indignities expressed through verbal or behavioral means. In China, microaggressions have proliferated with the wide implementation of education protection policies for disabled children (including learning in regular classes (LRC), special school education (SSE), and home-delivery education (HDE)), resulting in severe consequences. However, related issues have not been discussed yet. OBJECTIVE: This study explores concrete forms of microaggressions that disabled children have experienced under three educational policies. METHODS: We took a

Prospective, longitudinal study to isolate the impacts of marijuana use on neurocognitive functioning in adolescents.

INTRODUCTION: Policies to legalize possession and use of marijuana have been increasingly supported across the United States. Although there … ths apart. RESULTS: Results suggest that marijuana use may be specifically related to a decline in verbal learning ability in the short term and in emotion recognition, attention, and inhibition in the longer-term. DISCUSSION: These preliminary findings suggest that marijuana use has potential to adversely impact vulnerable neurodevelopmental processes during a …

Machine learning polysomnographically-derived electroencephalography biomarkers predictive of epworth sleepiness scale.

Excessive daytime sleepiness (EDS) causes difficulty in concentrating and continuous fatigue during the day. In the clinical setting, the assessment and diagnosis of EDS rely mostly on subjective questionnaires and verbal reports, which compromises the reliability of clinical diagnosis and the ability to robustly discern candidacy for available therapies and track treatment response. In this study, we used a computational pipeline for the automated, rapid, high-throughput, and objective analysis of previously collected encephalography (EEG) data to identify surrogate biomarkers for EDS, thereb

Longitudinal amyloid cognitive composite in preclinical Alzheimer's disease.

BACKGROUND AND PURPOSE: Previous studies have developed several cognitive composites in preclinical Alzheimer disease (AD). However, more se … and the LACPA. RESULTS: Considering the group-time interaction effects of each subtest, the Seoul Verbal Learning Test-Elderly version immediate recall/delayed recall/recognition, the Korean Trail Making Test B Time, and the Korean Mini-Mental State Examination were selected as components of the LACPA. The LACPA exhibited a significant group-time interaction ef …

Altered regional homogeneity and cognitive impairments in first-episode schizophrenia: A resting-state fMRI study.

BACKGROUND: Patients with schizophrenia consistently present pervasive cognitive deficits, but the neurobiological mechanism of cognitive im … (speed of processing, attention/vigilance and social cognition); PCC was positively correlated with verbal learning; right superior occipital gyrus was positively correlated with speed of processing and social cognition. CONCLUSION: In conclusion, we found widespread ReHo alterations and cognitive dysfunction in FES. And the pathophysiology mechanism of a wide r …

Impaired Behavioral Pattern Separation in Refractory Temporal Lobe Epilepsy and Mild Cognitive Impairment.

OBJECTIVE: Episodic memory impairment and hippocampal pathology are hallmark features of both temporal lobe epilepsy (TLE) and amnestic mild … T). Group differences were evaluated and relationships between clinical characteristics, California Verbal Learning Test-Second Edition scores, and MST performance were tested in the TLE group. RESULTS: Patients with TLE and aMCI demonstrated poorer PS performance relative to the HCs, but performance did not differ between the two patient groups. Neither the sid …

Metabolic Syndrome and Cognitive Function in Midlife.

OBJECTIVE: Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors associated with cognitive decline. We investigated the rela … d Edition), EF (Stroop Color Word, Digit Span Backward, and Trails A and B), and memory (California Verbal Learning Test, 2 Edition). RESULTS: Higher number of MetS components was related to weaker EF-F(4, 191) = 3.94, p = .004, MetS components ß = -.14, p = .044. A similar relationship was detected for tests of memory-F(4, 192) = 7.86, p < .001, MetS components …