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Microsurgical replantation of the lip: a multi-institutional experience.

Traumatic amputation of the lip is a rare yet devastating event affecting both form and function. Considering the available methods for reconstruction, replantation may offer a reasonable solution. We sought to characterize the variables associated with lip replantation and to assess the outcome in a retrospective review of 13 lip replantations performed in 12 institutions utilizing a form database and clinical and photographic analysis. Lip replantation was successful in all 13 patients; partial flap loss occurred in one patient owing to iatrogenic injury. Follow-up averaged 3.1 years. Averag

Disintegrins from hematophagous sources.

Bloodsucking arthropods are a rich source of salivary molecules (sialogenins) which inhibit platelet aggregation, neutrophil function and angiogenesis. Here we review the literature on salivary disintegrins and their targets. Disintegrins were first discovered in snake venoms, and were instrumental in our understanding of integrin function and also for the development of anti-thrombotic drugs. In hematophagous animals, most disintegrins described so far have been discovered in the salivary gland of ticks and leeches. A limited number have also been found in hookworms and horseflies, and none i…

Эндемическая болезнь, похожая на тиф, Чили.

Сообщаем, что 54-летний мужчина, который был укушен несколькими наземными пиявками во время поездки на остров Чилоэ в южной части Чили в 2006 году, был укушен тифом. Молекулярный образец, идентифицированный как относящийся к цутсугамуши на основе последовательности гена 16S rRNA, был получен из биопсии эшара на ноге пациента. Серологический анализ показал, что иммуноглобулин G преобразуется в антиген целой клетки О. цутсугамуши. Этот случай и связанные с ним молекулярные анализы свидетельствуют о том, что в Западном полушарии присутствует агент, похожий на Ориентию, который может вызывать боле

Совпадение в аннотации оригинала
We report a case of scrub typhus in a 54-year-old man who was bitten by several terrestrial leeches during a trip to Chiloé Island in southern Chile in 2006. A molecular sample, identified as related to Orientia tsutsugamushi based on the sequence of the16S rRNA gene, was obtained from a biopsy specimen of the eschar on the patient's leg. Serologic analysis …

Strategies to increase flap survival in nasal reconstruction in patients with deep panfacial burns.

Total nasal reconstruction requires the management of skin, cartilage, and nasal mucosa. This three-dimensional surgical approach is especially restricted in patients with severe deformities after deep panfacial burns. In this regard, the development of tissue fibrosis reduces the quality and reliability of surrounded donor sites, limiting the surgical options and flap survival outcomes. This report discusses the benefit of tissue protection procedures, such as flap delay and leech therapy, in the total nasal reconstruction of a patient with split-thickness skin grafts on donor sites for foreh

Scalp replantation after traumatic injury.

A 30-year-old female patient lost her scalp in an industrial accident. Surgeons used a microscope to reconnect the arteries and veins in her scalp and to reattach the scalp to the patient's cranium. The patient tolerated the procedure without complications, although she developed venous congestion in her right ear while she was in the neuroscience intensive care unit. After several days of leech therapy, the patient experienced an uneventful postoperative course. One month after discharge from the hospital, the patient's hair was growing back in and her incision lines were fading.

Pediatric abdominal radiograph use, constipation, and significant misdiagnoses.

OBJECTIVE: To determine the proportion of children diagnosed with constipation assigned a significant alternative diagnosis within 7 days (misdiagnosis), if there is an association between abdominal radiograph (AXR) performance and misdiagnosis, and features that might identify children with misdiagnoses. STUDY DESIGN: We conducted a retrospective cohort study of consecutive children <18 years who presented to a pediatric emergency department in Toronto, between 2008 and 2010. Children assigned an International Statistical Classification of Diseases and Related Health Problems 10th Revision c

[Cloning and expression analysis of wpHSP90 gene from Whitmania pigra at different temperatures].

HSP90 is a widely distributed molecular chaperone that participates in a variety of cellular processes and plays an important role in the meiosis of germ cells. However, its role in the gonadal development of hermaphroditic Whitmania pigra is not yet clear. To explore the effect of HSP90 on the germ cell development of Wh. Pigra, this study cloned the wpHSP90 gene, performed bioinformatics analysis, and measured its expression levels. The results showed that the cloned wpHSP90 was 2 592 bp in length, with an open reading frame(ORF) of 2 373 bp, encoding 790 amino acids. Prediction analysis rev

Prevalence of musculoskeletal pain and environmental health hazards among tea pluckers of Maddekanda tea estate in Balangoda Pradeshiya Saba Division, Sri Lanka.

Background: Tea pluckers in Sri Lanka play a prominent role in supplying tea for the local and foreign demand. Long standing, bearing weight on back, repetitive hand movements, slip and falls due to walking on uneven grounds lead to various health problems among them. Thus, this study was aimed to assess the prevalence of musculoskeletal pain and environmental health hazards among tea pluckers of Maddekanda tea estate in Balangoda area, Sri Lanka. Design and Methods: A descriptive cross-sectional study was carried out among 378 tea pluckers, recruited using simple random sampling method. Data

Plain abdominal radiograph as an evaluation method of bowel dysfunction in patients with spinal cord injury.

OBJECTIVE: To evaluate the usefulness of plain abdominal radiography as an evaluation method for bowel dysfunction in patients with spinal cord injury (SCI). METHODS: Forty-four patients with SCI were recruited. Patients were interviewed about their clinical symptoms, and the constipation score and Bristol stool form scale were assessed. The colon transit time (CTT) was measured by using radio-opaque markers (Kolomark). The degree of stool retention and the presence of megacolon or megarectum were evaluated using plain abdominal radiographs. We examined the relationship between clinical aspec

Reconstruction of a large defect of the ear using a composite graft following a human bite injury.

Human bites to the ear are not an uncommon injury as a consequence of brawls or even contact sports like rugby. Untreated, the cosmetic outcome of such injury is unsightly. This case history documents how a patient, who had two-thirds of his external ear bitten off, was treated successfully by replacing the part as a composite graft. The segment replanted was minimally trimmed but inset to allow maximal soft tissue apposition at the skin edges. An episode of postoperative venous congestion was treated with leeches. Patience was exercised rather than early debridement of any struggling tissue. …

[Research progress on processing history evolution, chemical constituents, and pharmacological effects of Hirudo].

As a traditional animal drug, Hirudo is slightly toxic and has the effects of breaking blood stasis, dredging meridians, expelling stasis, and resolving mass. It has a long history of processing, and the early boiling records can be traced back to the Han Dynasty. More than ten processing methods such as frying, roasting, and lime processing appeared later. After processing, Hirudo is deodorized and modified in taste and becomes crispy, which is conducive to crushing and clinical application. At present, the reported components in Hirudo mainly include protein polypeptides, pteridines, and lip

Effects of modeling and topic stimulus on self-referent touching.

Self-touching is defined as self-directed touches, e.g., scratching or rubbing, that have no apparent conscious motivation. Earlier research on self-touching focused on internal processes associated with self-touching, e.g., mental conflict, while more recent research has considered external motivators, such as an auditory or visual presentation of a provocative stimulus, e.g., leeches. Here, 110 undergraduate psychology students (68 women, 42 men; M age = 18.7 yr., SD = 1.0) were shown a video about chiggers to replicate previous findings, while simultaneously studying the social influence of…

Laser microbeam axotomy and conduction block show that electrical transmission at a central synapse is distributed at multiple contacts.

Touch (T) sensory neurons in the leech innervate defined regions of skin and synapse on other neurons, including other T cells, within the ganglionic neuropil. The cells' receptive fields in the periphery are comprised of a central region, innervated by thick axons, and adjoining regions (minor fields) innervated by thinner axons. Secondary branches, known to be sites of synapses, emerge from the thinner and thicker axons. Pairs of T cells appear to make up to 200 separate contacts distributed within the neuropil. When the T cell is hyperpolarized, as occurs during natural stimulation of the c

Species delimitation recovers undescribed Erpobdellidae (Annelida: Hirudinea) from USA and Trkiye.

Erpobdellid leeches are morphologically similar to each other and thus cause confusion in taxonomic identification. In particular, annuli, colour and eye patterns are very close across species which creates difficulties in external morphological resolution. Here we describe six new species of Erpobdellidae collected from North America and Europe based on morphological and molecular criteria. New species are formally designated Erpobdella farmensis sp. nov., Erpobdella haddonensis sp. nov., Erpobdella madenensis sp. nov., Dina sivricensis sp. nov., Dina takasensis sp. nov. and Trocheta kesirven…

Occupational Hazards Faced by Inland Fishers of Odisha State, India.

OBJECTIVE: To identify occupational hazards and hazard control strategies adopted by inland fishers of Odisha state in India. METHODS: Information on occupational hazards faced by fishers was collected by personal interviews with 90 riverine and reservoir fishers of Odisha. Through qualitative discussions with key informants and review of literature, a list of occupational hazards were prepared and classified into physical, ergonomics, psychosocial, and natural. Responses were quantified, and descriptive statistics were used for data analysis. RESULTS: Occupational hazards faced by fishers w

The crystal structure of an intramolecular trans-sialidase with a NeuAc alpha2-->3Gal specificity.

BACKGROUND: Intramolecular trans-sialidase from leech (Macrobdella decora) is a unique enzyme which cleaves the terminal neuraminic acid (NeuAc) residue from sialoglycoconjugates, releasing 2, 7-anhydro-neuraminic acid (2,7-anhydro-NeuAc). It is the first enzyme found to exhibit strictly specific cleavage of NeuAc alpha2-->3Gal linkages in sialoglycoconjugates. The release of 2,7-anhydro-NeuAc instead of NeuAc implies a unique mechanism, in which the sialosyl linkage is transferred within the sialoglycoconjugate rather than hydrolyzed. The aims of the structural study were to gain structural i

Mucosal hirudiniasis presenting as palatal mass: A case report and review of the literature.

This paper presents the case of a 5-year-old child who presented with an 15-day history of a swelling over the palatal region and blood stained saliva. Intraoral examination showed dark red circular mass rising from the hard palate. Diagnosis of mucosal hirudiniasis have been made. The parasite has been extracted under local anesthesia using a blunt forceps, it has been identified as an adult Limnatis nilotica. Leech endoparasitism must be suspected in case of bleed from throat, dysphagia or any other related symptom, especially in pediatric patients who have been exposed to freshwater. Preven

Microsurgical reattachment of totally amputated ears.

At a time when microsurgical reattachment of amputated limbs is commonplace, successful reattachment of total ear amputations is rare. Avuls … wo of the three patients. Anticoagulation was essential in alleviating venous thrombosis. Medicinal leeches (Hirudo medicinalis) were used to salvage one case with venous thrombosis. Despite the technical difficulties and long operative times, successful microvascular reattachment of an amputated ear is superior to any other means of reattachment or recon …

Ultrastructural Architecture and Morphological Examination of Hirudo verbana (Annelida, Hirudinea).

In this study, the morphological characteristics of the medicinal leech Hirudo verbana (Annelida, Hirudinea) were examined. Mitochondrial CO1 gene sequences of representative specimens were recorded in GenBank, and macroscopic, histological, and SEM analyses of remaining representatives were made. The species had trignathous jaws, each half-moon in shape. There were 75-80 denticles on the left jaw with their tips medially, while the right jaw had 30-34 equilateral triangular denticles, all arranged in a single row. The anterior jaw had 35-40 blunt-tipped denticles similarly arranged in a singl