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Surgery for pelvic organ prolapse: a historical perspective.

Surgical treatment of pelvic organ prolapse has evolved from the use of pomegranates as pessary devices to contemporary robot-assisted laparoscopic sacral colpopexy. Symptomatic pelvic organ prolapse requires correction of all the defects to achieve optimal outcomes. Factors to consider in selecting the appropriate repair include patient's age; stage of prolapse; vaginal length; hormonal status; desire for uterine preservation and coitus; symptoms of sexual, urinary, or bowel dysfunction; and any comorbidities that influence her eligibility for anesthesia or chronically increase intra-abdomina…

Treatment with Punica granatum var. pleniflora Inhibits Postoperative Adhesion Formation in a Rat Uterine Horn Adhesion Model.

OBJECTIVE: Despite recent advances in surgical procedures, postoperative peritoneal adhesions are common following major abdominopelvic surgery. Here, the therapeutic potential of Punica granatum var. pleniflora (PGP) on postoperative peritoneal adhesions has been explored in a rat uterine horn adhesion model. METHODS: Eighteen Albino Wistar female rats were divided into three groups: control group, sham, and treatment group receiving 400 mg/kg/day PGP orally for ten days. An identical surgical technique was employed to induce adhesion of the uterine horn in both the control and treatment gro

Punica granatum and amygdalin extracts plus cobalamin combined with albendazole reduce larval burden and myositis in experimental trichinosis.

Trichinellosis is a zoonosis results from eating raw or semi-cooked meat of infected animals. Medicinal plants have been used lately as alternatives and/or combined therapies to resolve some drawbacks of the current regimens. This work analyzed the effect of albendazole monotherapy on Trichinella spiralis experimental infection (group A), in comparison to P. granatum and amygdalin extracts +cobalamin (group B), plus its combination with albendazole (group C). The study revealed that the extracts alone or combined with albendazole had an inferior effect to albendazole monotherapy regarding numb

Pan-genome and antibiotic resistance insights into Xanthomonas citri pv. punicae pathotypes.

BACKGROUND: Bacterial blight, caused by Xanthomonas citri pv. punicae (Xcp) is a significant threat to pomegranate cultivation in India. Although antibiotics such as streptomycin, streptocycline, and tetracycline are commonly used for its management, their effectiveness is declining due to the emergence of resistant Xcp strains carrying acquired resistance genes. Considering this growing concern, the present study aimed to investigate nine Xcp isolates obtained from pomegranate-growing regions of India by assessing their pathogenicity, followed by in vitro evaluation of their antibiotic sensit…

Sugar-Responsive Enzyme-Polyphenol 'Tooth Nanoarmor' for Long-Lasting Caries Prevention via Glucose Depletion and Biofilm Suppression.

High sugar intake in modern dietary patterns heightens the risk of dental caries, yet current preventives neither address dietary sugars nor effectively inhibit cariogenic biofilms. Herein, we introduce a fully biomass-derived enzyme-polyphenol 'tooth nanoarmor' that self-assembles from glucose oxidase (GOx) and ellagic acid, a natural phenolic molecule found in pomegranate peels and tree bark. Noncovalent interactions mediate the self-assembly, yielding a porous supramolecular phenolic framework, with nanochannels exhibiting remarkable bioadhesion and biostability. Adhering to tooth enamel, t…

Punicalagin inhibits neuron ferroptosis and secondary neuroinflammation to promote spinal cord injury recovery.

Spinal cord injury (SCI) represents a severe type of central nervous system damage, with no effective treatment currently available, partly due to neuronal ferroptosis and subsequent neuroinflammation. Punicalagin, an anti-inflammatory compound extracted from pomegranate peel, has exhibited therapeutic potential for inflammatory diseases. In this study, we present evidence that punicalagin facilitates the recovery of neurological function following SCI by mitigating neuronal ferroptosis. Mechanistically, this effect involves the upregulation of nuclear factor E2-related factor 2 (Nrf2) and the…

Relationship between rheological properties, sensory perception, and overall acceptability of thickened liquids for dysphagia in young and old healthy individuals.

This study investigated the relationship between rheological properties, sensory perception, and overall acceptability in healthy young and old groups for dysphagia thickened liquids. Unflavored (UTL) and flavored (FTLP) thickened liquids were prepared using tap water or pomegranate juice at 10 different viscosity levels. The rheological properties were then evaluated via syringe flow test and line spread test (LST). When the apparent viscosity levels of UTL and FTLP were similar, the syringe test and LST results were also similar, indicating consistent flow behavior. Sensory perception evalua…

In Vitro Xanthine Oxidase Inhibition, DNA Protection, Anti-Inflammatory, Antioxidant Activity, Phytochemical Analysis, and In Silico Studies of Punica granatum Peels and Flowers.

This study investigated the antioxidant, anti-inflammatory activities, xanthine oxidase (XO) inhibition, DNA protective effects, and phytochemical contents of ethanol (E) and methanol (M) extracts of Punica granatum (pomegranate, PG). It also aimed to determine the inhibitory properties of epigallocatechin against the XO enzyme theoretically through molecular docking, molecular dynamics (MD), and MM-PBSA analyses, and to explore the pharmacokinetic properties of this component. PGFE showed the highest DPPH• activity, while PGFM exhibited the highest FRAP activity. PGPM demonstrated a higher in…

Development of food-origin biochars for the adsorption of selected volatile organic compounds (VOCs) for environmental matrices.

Four novel fruit-derived biochars were developed: pomegranate peels (PB), prickly pear peels (PPB), carob (CB), and locust bean gum (LBGB). The feedstocks were pyrolyzed at 350 and 550 ℃ (under N2), respectively, and characterized using Scanning Electron Microscopy (SEM), Elemental Analysis (EA), Diffuse Reflectance Infrared Fourier Transform Spectroscopy (DRIFTS), Brunauer-Emmett-Teller (B.E.T) analysis, and Thermogravimetric analysis (TGA). A systematic and comprehensive comparison for the adsorption of selected volatile organic compounds (VOCs) by biochar was established. Cresol, dimethyl t…

Innovations in natural ingredients and their use in skin care.

Natural ingredients have been used traditionally for millennia and their application in topical creams, lotions and preparations within the … ntation and antioxidative capabilities, licorice, green tea, arbutin, soy, acai berry, turmeric and pomegranate are among those plants and compounds found to be most beneficial. Additional research is needed to determine to confirm and elucidate the benefits of these ingredients in the prevention and management of skin disease.

Dental applications of Punica granatum L. in the treatment of gingivitis: A review of ethnomedicinal uses, randomized clinical trials, and antibacterial potential against Porphyromonas gingivalis.

ETHNOPHARMACOLOGICAL RELEVANCE: Mouthwashes based on medicinal plants have demonstrated benefits in controlling plaque and inflammation, acting positively on the oral hygiene of patients with gingivitis. In traditional medicine, Punica granatum L. has been used to treat oral diseases in countries in Europe, Asia, North America, and Africa. AIM OF THE STUDY: The present study aimed to conduct a comprehensive review on the dental applications of Punica granatum L. for the treatment of gingivitis, including ethnomedicinal uses, analysis of randomized clinical trials, antibacterial activity again

Punica granatum Seed Essential Oil Suppressed Methadone-Induced Cell Death by Natural Antioxidant Activity.

OBJECTIVES: Methadone is an opioid used in treating chronic and acute pains as well as opioid dependence. It induces death in neural cells. This study investigates Punica granatum oil's effects as a natural antioxidant on methadone-induced cell death. MATERIALS AND METHODS: The cell death index indicating the apoptosis occurrence is calculated using the TUNEL test. Rhodamine123 evaluated mitochondrial membrane permeability. Griess reaction was used to detect nitric oxide production. Furthermore, IL-1β, IL-6, INFγ, and TNFα inflammatory cytokines were measured using the Rat inflammatory cytoki

Ellagic Acid as a Sustainable Multifunctional Agent: Primary Effects, Mechanisms, and Skin Health Applications.

Ellagic acid (EA), a natural polyphenol found in fruits like pomegranates and strawberries, has gained significant attention in skin health due to its multifaceted bioactivities, including skin depigmentation, antioxidant, anti-photoaging, anti-inflammatory, and antibacterial effects. Sourced sustainably from agricultural by-products, EA is an environmentally friendly ingredient. This review evaluates these primary bioactivities, emphasizing its role in modulating reactive oxygen species (ROS) as a central mechanism. It also summarizes extraction strategies and advancements aimed at enhancing …

High pressure homogenization applied to fruit juices: Effects on microbial inactivation and on maintenance of bioactive components.

High-pressure homogenization (HPH) is a non-thermal technology widely studied to replace, partially or in total, the conventional thermal pr … eported were apple, apricot, banana, blackberry, carrot, kiwifruit, mandarin, mango, orange, peach, pomegranate, rosehip, strawberry and tomato. The paper elucidates the potential application of HPH to fruit juice processing aiming at producing safe products with high nutritional and sensory quality.

Assessment of polyphenol coated nano zero valent iron for hexavalent chromium removal from contaminated waters.

Alternative plant extracts were examined as raw materials for the synthesis of nZVI from ferric solutions. Four plants were selected for evaluation, i.e. Camellia sinensis (green tea, GT), Syzygium aromaticum (clove, CL), Mentha spicata (spearmint, SM) and Punica granatum (pomegranate, PG). Based on the results obtained, it was concluded that the reduction of Fe(III) with the herb extracts is not complete. Using the GT extract, approximately 28 mM of the initial 66 mM of Fe (42.4 %) are reduced to the elemental state Fe(0). The highest reduction of Fe(III), about 53 %, was achieved with PG and…

Effect of Some Plant-Based Substances on Microbial Content and Sperm Quality Parameters of Bull Semen.

The rapid emergence of antibacterial resistance requires alternatives to antibiotics to be found, including for semen preservation. One of the possible alternatives would be to use plant-based substances with known antimicrobial effects. The objective of this study was to test the antimicrobial effect of pomegranate powder, ginger, and curcumin extract in two concentrations on bull semen microbiota after exposure for <2 h and 24 h. An additional aim was to evaluate the effect of these substances on sperm quality parameters. The bacterial count in semen was low from the beginning; however, a re…

Задержка в росте заболеваемости мышей TgMHu2ME199K в результате объединения трансплантации ВСНП и управления Нано-ПСО.

gCJD — смертельное нервно-дегенеративное заболевание, связанное с мутациями в гене PPRP. Ранее мы показали, что трансплантация нейронных клеток-прекурсоров (НПК) или применение наноформуляции гранатового семенного масла (Nano-PSO, GranaGard) в новорожденные асимптоматические мыши TgMHu2ME199K, моделирующие E200K gCJD, значительно задержали развитие клинических заболеваний. В настоящем исследовании мы проверили индивидуальное и комбинированное воздействие как на старых, так и на больных мышей TgMHu2ME199K. Мы показываем, что в то время как трансплантация НПК как в начальный (140 дней), так и в

Совпадение в аннотации оригинала
gCJD is a fatal late-onset neurodegenerative disease linked to mutations in the PRNP gene. We have previously shown that transplantation of neural precursor cells (NPCs), or administration of a nanoformulation of pomegranate seed oil (Nano-PSO, GranaGard), into newborn asymptomatic TgMHu2ME199K mice modeling for E200K gCJD significantly delayed the advance o…

Pretreatment with Resveratrol Prevents Neuronal Injury and Cognitive Deficits Induced by Perinatal Hypoxia-Ischemia in Rats.

Despite advances in neonatal care, hypoxic-ischemic brain injury is still a serious clinical problem, which is responsible for many cases of perinatal mortality, cerebral palsy, motor impairment and cognitive deficits. Resveratrol, a natural polyphenol with important anti-oxidant and anti-inflammatory properties, is present in grapevines, peanuts and pomegranates. The aim of the present work was to evaluate the possible neuroprotective effect of resveratrol when administered before or immediately after a hypoxic-ischemic brain event in neonatal rats by analyzing brain damage, the mitochondrial…

A dual-biomimetic MOF integrated with a hydrogel microfluidic chip for dual-mode polyphenol detection.

The detection of polyphenols is critical for safeguarding nutritional quality and human health. A microfluidic device incorporating a dual-b … platform, total polyphenols and three individual polyphenols (GA, punicalagin and ellagic acid) in pomegranate peel (PPe) were successfully detected, with colorimetric detection limits below 32 nmol/L and fluorescence detection limits below 21 nmol/L. Based on the dual-biomimetic design, the platform achieved highly sensitive and rapid on-site visualization …

Molecular insights into protein disulfide isomerase antagonism by punicalagin.

Punicalagin, an ellagic acid polyphenol from pomegranate, has been proposed as an antagonist of protein disulfide isomerase (PDI) and endoplasmic reticulum resident protein 57 (ERp57), thiol oxidoreductases that regulate protein folding and extracellular thrombotic signaling. Here, biochemical oxidase and reductase assays on PDI show that punicalagin inhibits both activities with micromolar potency, thereby extending earlier work that described only disulfide reductase inhibition. In parallel, thiol labeling of catalytic cysteines revealed no change in the redox state, supporting a noncovalent…