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Modified atmosphere packaging delays enzymatic browning and extends the shelf life of fresh-cut lotus root by maintaining membrane lipid homeostasis.

Fresh-cut lotus root (FCLR) is prone to rapid browning and microbial growth after processing. Although modified atmosphere packaging (MAP) can inhibit browning in FCLR, the optimal gas composition and the physiological basis of browning inhibition remain unclear. In this study, a principal component analysis-assisted multi-index evaluation was employed to identify the optimal gas composition (MAP1: 1% O2, 15% CO2, 84% N2), followed by analyses of membrane lipid metabolism and untargeted metabolomics. After 15 d, MAP1 reduced browning by 72% and lowered mold/yeast counts and total aerobic count

Crafting probiotics a self-polymerized smart outfit for effective ulcerative colitis treatment.

Probiotic therapy has recently emerged as a promising approach for ulcerative colitis (UC) treatment. However, oral probiotic therapy is often hindered by challenges such as inferior colonization at lesion sites, where elevated intestinal hydrogen sulfide (H2S) level exacerbates epithelial barrier disruption. Moreover, without adjunct drugs, probiotics alone struggle to mitigate oxidative stress and persistent inflammation effectively. To address these issues, an alkali-labile polymerized ferulic acid (pFA) outfit was developed through a self-polymerization strategy, designed to both shield pr

Machine learning modeling for optimizing fermentation process of Dendrobium officinale with improved antioxidant property and metabolic changes.

Lactic acid bacteria (LAB) fermentation may affect chemical accessibility and can develop antioxidant properties of Dendrobium officinale (DO). This study integrated nine machine learning (ML) algorithms with Response Surface Methodology (RSM) to optimize polyphenol enrichment. XGBoost emerged as the superior predictive model (R2 = 0.982 ± 0.006, RMSE = 2.92 ± 0.076, and MAE = 2.35 ± 0.062), significantly outperforming the quadratic RSM model. LAB fermentation effectively enhanced bioactive small molecule production and radical scavenging activity (DPPH and ABTS) without reducing cell viabilit

Honokiol inhibits gastric cancer via tumor microenvironment modulation: a bioinformatics and single-cell analysis.

Honokiol, a natural polyphenol from Magnolia bark, exhibits antitumor effects in various cancers. This study aimed to elucidate its pharmacological mechanisms in gastric cancer. Active components and their targets were retrieved from the Traditional Chinese Medicine Systems Pharmacology Database and SwissTargetPrediction databases. Gastric cancer-related genes were collected from the Comparative Toxicogenomics Database and GeneCards databases. Overlapping targets were analyzed using STRING to construct a protein-protein interaction network. Gene Ontology and Kyoto Encyclopedia of Genes and Gen

Preparation and characterization of modified sunflower meal protein-quercetin nanoparticles: Shelf-life study of seasoned lamb kebabs.

This study developed a quercetin (Que) nanoencapsulation system (PU-SMP-Que) using phosphorylated and ultrasonicated sunflower meal protein (PU-SMP) as the carrier. At a protein-polyphenol mass ratio of 15:1, the spherical PU-SMP-Que nanoparticles exhibited an average diameter of 175.3 nm, a polydispersity index of 0.351, and a high encapsulation efficiency of 98.09 %. Spectroscopic and X-ray diffraction analyses confirmed the incorporation of Que into amorphous PU-SMP matrices through hydrogen bonding, electrostatic, hydrophobic, and van der Waals interactions. Nanoencapsulation significantly

Epigallocatechin-3-gallate binds tandem RNA recognition motifs of TDP-43 and inhibits its aggregation.

Transactive response DNA-binding Protein 43 (TDP-43) aggregation is a key pathological feature in Amyotrophic Lateral Sclerosis and related neurodegenerative diseases. This study investigates the inhibitory effects of Epigallocatechin-3-gallate (EGCG), a polyphenol found in green tea, on TDP-43 aggregation. Using a combination of fluorescence assays, NMR spectroscopy, and computational modeling, we demonstrate that Epigallocatechin-3-gallate significantly delays the nucleation phase of TDP-43 aggregation process, thus inhibiting the formation of TDP-43 aggregates in vitro. Additionally, we pro

Oatmeal and wheat flour as the sources of thyroid peroxidase and proinflammatory enzymes modulators in the prevention of thyroid diseases.

Polyphenolic plant compounds possess nutritional and pro-healthy potential, reducing the risk of auto-inflammatory and neoplastic diseases. However, their interference with the progression of thyroid gland dysfunctions has remained largely unaddressed. For this purpose, we combined the analyses of phenolic content and antioxidative activity with the thyroid peroxidase (TPO), lipoxygenase (LOX), xanthine oxidase (XO) and cyclooxygenase-2 (COX-2) activity assays, isobolographic approach and the estimation of thyroid cancer cells' proliferation and motility in vitro. Bioaccessible oatmeal (OM) an

Resveratrol: Molecular Mechanisms, Health Benefits, and Potential Adverse Effects.

Resveratrol (RES), a naturally occurring polyphenolic compound, has garnered significant attention due to its diverse biological activities, which include anti-inflammatory, antioxidant, and antiaging properties. This review synthesizes current evidence concerning the molecular mechanisms, therapeutic efficacy, and safety profile of RES across a variety of pathologies, with an emphasis on the latest research conducted in recent years. Mechanistically, RES is known to modulate critical signaling pathways such as the activation of sirtuin 1. These actions collectively contribute to the attenuati

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… RES is recognized as the most potent polyphenolic activator of sirtuins in vitro. RES orchestrates the regulation of several critical signaling pathways through the activation of sirtuins, particularly SIRT1. … Xiao , “ Polyphenols Targeting NF‐κB Pathway in Neurological Disorders: What We Know So Far? ,” Int J Biol Sci 20 , no. 4 ( 2024 ): 1332 – 1355 . 38385077 10.7150/ijbs.90982 PMC10878147 37 W. Dong , K. Zhang , X. …

Pharmacological Evaluation of Respiratory Safety Following a Single Intravenous Administration of Theophylline in Sprague-Dawley Rats.

Drinking tea is an important cultural and sensory activity in modern society. However, tea consumption may influence biological functions because of its high polyphenol and methylxanthine content. Theophylline is a methylxanthine that plays a significant role in respiratory physiology and is used clinically as a bronchodilator. In this study, we assessed the pharmacological safety of theophylline by investigating its effects on the respiratory responses of experimental rodents. Six-week-old male Sprague-Dawley rats were intravenously administered 0, 2.5, 5, or 10 mg/kg theophylline. After syst

Fabrication of Dialkyl Dithiophosphate-Functionalized Carbon Aerogel Microspheres for Enhanced Lubrication Performance.

Herein, functionalized carbon aerogel microspheres (CAMs) were successfully prepared by the pyrolysis of resorcinol-formaldehyde (RF) microspheres followed by surface modification. First, RF microspheres were carbonized to obtain CAMs. Afterward, the polyphenolic compound of epigallocatechin gallate (EGCG) was reacted with melamine to form a poly(EGCG) layer onto the CAM surface, followed by bonding the antiwear molecule dialkyl dithiophosphate (DDP) by the Michael addition, resulting in DDP-functionalized CAMs (DDP-CAMs). The grafting antiwear molecule DDP improved the lipophilicity of the CA

Enhanced Antioxidant and Anti-inflammatory Properties of Albino Cordyceps militaris: A Comparative Study With Wild-type Strain.

Cordyceps militaris is a medicinal fungus known for its immunomodulatory effects. This study compared the antioxidant and anti-inflammatory activities of an albino strain (C. militaris SHBTQ) and its wild-type counterpart (SHQ) using ethanol extracts from their fruiting bodies. The albino strain exhibited significantly higher bioactive compound levels, with cordycepin and pentostatin concentrations 2.37- and 1.74-fold higher than in the wild type. Enhanced polyphenol and flavonoid content correlated with stronger 1,1-diphenyl-2-picrylhydrazyl and azino-bis-(3-ethylbenzothiazoline sulfonate) ra

Quinine-chalcone hybrids as potent inhibitors of P-glycoprotein with apoptotic effects on EBC-1 cells.

Chincona alkaloids extracted from the bark stem of Cinchona officinalis have been historically used to treat fever and malaria. More recently, cinchona alkaloid derivatives have been attributed to apoptotic effects in the context of cancer. Similarly, chalcones are plant-derived polyphenolic compounds with known anti-fungal, -microbial, -malarial, and -carcinogenic properties. Here, we reveal cytotoxic and antiproliferative characteristics of synthetic quinine-chalcone hybrids in human cancer cell lines. Two derivatives (AD-12 and AD-13) presented IC50 values below 2 µM in the lung squamous ce

Mechanistic Perspectives on Herpes Simplex Virus Inhibition by Phenolic Acids and Tannins: Interference with the Herpesvirus Life Cycle.

Herpes simplex virus (HSV) is a prevalent and persistent human pathogen belonging to the family Herpesviridae and classified as an alpha-herpesvirus. It comprises two distinct types, HSV-1 and HSV-2, which together infect a significant portion of the global population and pose substantial public health challenges. HSV-1 is typically associated with oral herpes, while HSV-2 primarily causes genital herpes; both are characterized by recurrent lesions, latent infection, and mucocutaneous discomfort. Conventional antiviral drugs such as acyclovir and its derivatives are limited by drug resistance,

Морин гидрат: всеобъемлющий обзор терапевтического потенциала лечения неврологических заболеваний.

Фон: Морин гидрат представляет собой полифеноловый флавоноид, присутствующий в различных видах овощей, фруктов, орехов и морских продуктов. Согласно сообщениям, этот обзор позволяет выявить молекулярные механизмы и терапевтический потенциал Морина в связи с неврологическими заболеваниями, включая болезнь Паркинсона, болезнь Альцгеймера, травматическое повреждение мозга, нейропатическую боль, инсульт, болезнь Хантингтона, множественный склероз, амиотропический боковой склероз, депрессия, беспокойство, сон, энцефалопатию, шизофрению и психоз и т.д. энзиматическое ингибирование. Вывод: Несмотря н

Influence of Organic Nitrogen Derived from Recycled Wine Lees and Inorganic Nitrogen on the Chemical Composition of Cabernet Sauvignon Wines Fermented in the Presence of Non-Saccharomyces Yeasts Candida boidinii, C. oleophila, and C. zemplinina.

In this study, the influences of inorganic nitrogen source (INS) and organic nitrogen source (ONS) supplementation during the wine fermentation process using three non-Saccharomyces yeasts (Candida zemplinina, Candida oleophila, and Candida boidinii) were analyzed. Diamine phosphate (DAP) was used as an INS, and lees enzymatic hydrolysate was used as an ONS. Complete alcoholic fermentation and a higher concentration of volatile compounds were obtained in fermentations with ONS, mainly esters from 81 to 4564 µg/L, alcohols from 231 to 7294 µg/L, and isoamyl acetate ester compounds from 12.3-22.

A comprehensive review on the impact of hesperidin and its aglycone hesperetin on metabolic dysfunction-associated steatotic liver disease and other liver disorders.

The purpose of this review is to examine the effects of hesperidin and hesperetin on liver disorders. Metabolic dysfunction-associated steatotic liver disease is a complicated disorder influenced by many factors, including inflammation, diabetes and obesity. Currently, the most prominent treatment method is lifestyle changes. If left untreated, it can progress to cirrhosis, liver fibrosis and liver cancer. Hesperidin, which is a flavanone glycoside polyphenolic plant compound, belongs to the flavanone class and was first isolated from citrus peel. Hesperidin includes aglycone hesperetin and ru

Gallic acid pretreatment mitigates parathyroid ischemia-reperfusion injury through signaling pathway modulation.

Thyroid surgery often results in ischemia-reperfusion injury (IRI) to the parathyroid glands, yet the mechanisms underlying this and how to ameliorate IRI remain incompletely explored. Our study identifies a polyphenolic herbal extract-gallic acid (GA)-with antioxidative properties against IRI. Through flow cytometry and CCK8 assays, we investigate the protective effects of GA pretreatment on a parathyroid IRI model and decode its potential mechanisms via RNA-seq and bioinformatics analysis. Results reveal increased apoptosis, pronounced G1 phase arrest, and significantly reduced cell prolifer

A new strategy for the treatment of Parkinson's disease: Discovery and bio-evaluation of the first central-targeting tyrosinase inhibitor.

The high level of tyrosinase leads to the generation of neuromelanin, further causing the abnormality of redox-related protein level and mediating the occurrence and development of Parkinson's disease (PD). However, the existing tyrosinase inhibitors are mostly natural product extracts or polyphenolic derivatives, which hindered them from penetrating the blood-brain barrier (BBB). Herein, we obtained a novel tyrosinase inhibitor, 2-06 (tyrosinase: monophenolase IC50 = 70.44 ± 22.69 μM, diphenolase IC50 = 1.89 ± 0.64 μM), through the structure-based screening method. The compound 2-06 presented

The influences of extraction methods on the chemical constituents of Lyonia ovalifolia (wall.) Drude and intracellular protective effects based on metabolomics analysis.

Lyonia ovalifolia (Wall.) Drude (LO) is mainly distributed in China with health benefits. In this study, LO buds (LOB) were extracted by ultrasonic extraction (UE) with or without ultra-high-pressure (UHP-UE), microwave (MW-UE), subcritical (SC-UE) techniques. The metabolomic result showed that a total of 960 chemical compounds and 117 differential compounds were identified from LOB extracts. The UHP-UE extract was rich in total polyphenol and flavonoid contents, followed by MW-UE, UE and SC-UE extracts, respectively. All LOB extracts increased superoxide dismutase (SOD) and catalase (CAT) act

On the health effects of curcumin and its derivatives.

Turmeric (Curcuma longa) is an herbaceous plant that contains a phytochemical which is bright yellow and is known as curcumin. Turmeric, a member of Zingiberaceae family, has extensive application worldwide due to its beneficial medicinal attributes and is extensively used as a medicinal plant. Most people use turmeric as a spice, and it is a chief source of polyphenol curcumin. Curcuma longa has therapeutic properties, and since the initial extraction of curcumin from this plant, it has gained prodigious consideration from scientists in the medical field. The biological properties of curcumin