Результаты поиска

[Multiple sclerosis and pelvic floor disorders].

This review explores the impact of multiple sclerosis (MS) on pelvic organ function. Beyond the classical symptoms, MS might lead to voiding dysfunctions, faecal incontinence, and/or constipation, and/or sexual dysfunctions for both men and women. Pelvic organ dysfunction is stigmatising and often considered taboo. Therefore, it is crucial to address these issues through comprehensive medical history taking and examinations. Effective treatments are available for all dysfunctions, and a multidisciplinary approach is recommended to enhance the quality of life for patients.

Astrocyte Functional Heterogeneity in Multiple Sclerosis.

Multiple sclerosis (MS) is a chronic neuroinflammatory disease characterized by demyelination and axonal degeneration. Astrocytes have emerged as pivotal regulators of MS pathology, playing both pathogenic and regulatory roles. This review explores the mechanisms underlying astrocyte heterogeneity in MS, with a focus on how astrocyte functional states are influenced by extrinsic environmental factors such as inflammatory signals and dynamic interactions with immune cells and other glial populations. We discuss how the astrocyte heterogeneity established during development and further modulated…

[Age-related aspects of multiple sclerosis].

OBJECTIVE: To evaluate the epidemiology and clinical features of multiple sclerosis (MS) patients in late adulthood and old age. MATERIAL AND METHODS: MS registry data from the Scientific and Educational Center for the Study of Demyelinating Diseases at Yaroslavl State Medical University were analyzed over a 12-year period. The study included 25 patients with MS onset at age 50 or older, for whom detailed information was available. The comparison group comprised 20 patients with MS onset before age 30. RESULTS: Secondary-progressive MS was more prevalent among patients with late-onset diseas…

Urodynamic Voiding Patterns in Multiple Sclerosis.

AIMS: This study aimed to describe urodynamic voiding patterns in patients with MS (PwMS) using standardized assessments, and to compare the performance of the available nomograms and indices for obstruction and bladder contractility. METHODS: PwMS and lower urinary tract symptoms underwent cystometry and pressure flow studies. Fluoroscopy findings were collected when available. Bladder contractility was assessed using the following parameters: bladder voiding efficiency (BVE), bladder contractility index (BCI), Watts factor (WF) for men, Projected Isovolumetric Pressure 1 (PIP1), the Valenti

На пути к первичной профилактике множественных склерозов.

Множественный склероз (МС) является одной из наиболее распространенных причин инвалидности среди молодежи и, несмотря на появление высокоэффективных методов лечения заболеваний, остается неизлечимым заболеванием. Профилактика НР до начала обезвоживания является осуществимой, хотя и амбициозной целью. В настоящее время профилактические меры, подкрепленные адекватными доказательствами эффективности, отсутствуют, и оценка таких мер с применением традиционных методов пробного производства сопряжена с трудностями. Кроме того, высокая частотность и низкий эффект предполагаемых факторов риска НР, огр

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is among the most common causes of disability in the young and, despite the advent of highly effective disease-modifying therapies, remains an incurable disease. Prevention of MS before the onset of demyelination is a feasible, albeit ambitious, goal. Currently, preventive interventions with adequate evidence of efficacy are lacking, …

Повреждённая временная обработка в множестве склерозов.

Множественный склероз (MS) — хроническое аутоиммунное заболевание центральной нервной системы, которое повреждает серую и белую материю и снижает эффективность нейронной передачи. По данным исследований МРТ, ранние нейродегенерации в субкортических структурах, включая базальную ганглию (БГ), с микроструктурными повреждениями и изменчивой анизотропией тканей, о которых сообщается по всем подтипам MS, влияют на функциональную связь BG, а также связаны с усталостью. Учитывая центральную роль BG во временной обработке, мы предположили, что у людей с MS (PwMS) будет нарушено восприятие и двигательн

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system that damages grey and white matter and reduces neural transmission efficiency. Volumetric MRI studies indicate early neurodegeneration in subcortical structures, including the basal ganglia (BG), with microstructural damages and altered tissue anisotropy reported across all…

Множественный склероз: Вирусная глиопатия?

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Multiple sclerosis (MS) is believed to be caused by specific autoreactive B cells and T cells; however, definitive antigen targets remain unclear. …

Ocrelizumab для педиатрического восстановления множественных склерозов.

ЦЕЛЬ: Оценка эффективности и безопасности лечения окрилизумаба при педиатрии с множественным склерозом (POMS) (POCKGROHL): Пациенты POMS, как правило, имеют более высокие показатели рецидивов и перехода к среднему прогрессивному курсу обучения в более раннем возрасте по сравнению со взрослыми. Несмотря на то, что " Окрелизумаб " , рекомбинантная гуманитарная антиCD20 моноклональная IgG1, утвержденная УЛХ и ЕМА для взрослых пациентов с множественным склерозом (AOMS), в литературе имеются ограниченные данные о ее эффективности и безопасности в подгруппах ПОМС.МЕТОД: Было проведено ретр

Совпадение в аннотации оригинала
OBJECTIVE: To evaluate the effectiveness and safety of Ocrelizumab treatment for Pediatric-onset multiple sclerosis (POMS) BACKGROUND: POMS patients tend to have a higher rate of relapses and progression to secondary progressive course at earlier age compared to adult-onset MS. Although Ocrelizumab, a recombinant humanized anti-CD20 monoclonal IgG1, approved…

Оптимизация лечения педиатрического множественного склероза.

ВВЕДЕНИЕ: Педиатрический множественный склероз (POMS) отличается от взрослых MS в своих клинических характеристиках и курсах по болезням. В ПОМС наблюдается повышенная подстрекательская активность с более высокими показателями рецидивов и травмирования, наряду с менее ранними физическими недостатками, но более выраженными когнитивными нарушениями и ухудшением роста мозга. ОБЛАСТЬ ПРИМЕНЕНИЯ: В настоящем обзоре рассматривается стратегия обработки в рамках ПОМС на основе данных о безопасности и эффективности наблюдений и выборочных контролируемых испытаний. Эта статья основана на результатах пои

Совпадение в аннотации оригинала
INTRODUCTION: Pediatric-onset multiple sclerosis (POMS) differs from adult MS in its clinical characteristics and disease course. POMS exhibits a heightened inflammatory activity with higher relapse rates and lesion load, alongside less early physical disability but more pronounced cognitive impairment and impaired brain growth. AREAS COVERED: This review e…

Optical coherence tomography in multiple sclerosis.

BACKGROUND: Multiple sclerosis (MS) is a chronic neurodegenerative disease that damages myelinated fibers within the central nervous system. Data obtained using optical coherence tomography (OCT) have recently been identified as a potential biomarker for this disease. We aimed to measure circumpapillary retinal nerve fiber layer thickness (cpRNFLT) using OCT and to compare the results in healthy participants with those of individuals having clinically definitive MS with and without a history of optic neuritis. METHODS: This cross-sectional study recruited patients with clinically confirmed MS…

Palliative Care Aspects in Multiple Sclerosis.

CONTEXT: Multiple sclerosis (MS) is an inflammatory, chronic, demyelinating, and neurodegenerative disorder of central nervous system, determined by an auto-immune dysfunction. Severe disability generally occurs in patients with progressive forms of MS that typically develop either after an earlier relapsing phase or less commonly from disease onset. Despite advances in research to slow the progression of MS, this condition remains a life-limiting disease with symptoms impacting negatively the lives of patients and caregivers. OBJECTIVES: To analyze the difefrent aspects of palliative cae in …

Retinal Function in Advanced Multiple Sclerosis.

PURPOSE: People with multiple sclerosis (pwMS) experience autoimmunity-mediated inflammation and neurodegeneration throughout the central nervous system. There remains a need for clinically accessible, reliable functional markers of neurodegeneration in MS. Previous research has described changes to electroretinography (ERG)-derived measures of retinal bipolar cell function in pwMS early in the disease course. We, therefore, investigated ERG as a potential outcome measure in individuals with more advanced disease. METHODS: This cross-sectional observational study included pwMS with Expanded D…

Optociliary shunt vessels in multiple sclerosis.

BACKGROUND/INTRODUCTION: Optociliary shunt vessels develop as a result of chronic retinal venous obstruction. Optic neuritis has never been reported as a causative influence. OBJECTIVE: To determine whether optic neuritis predisposes to the development of optociliary shunts in patients with multiple sclerosis. CASES: This case series follows two patients with multiple sclerosis from August 1st, 2019 to April 24th, 2024, who developed optociliary shunt vessels after attacks of optic neuritis. A 43-year-old female presented with left visual loss and bilateral superior optociliary shunt vessels…

Множественная склерозовая помощь в Латинской Америке.

Латинская Америка (ЛАТАМ) представляет собой разнообразный регион с более чем 30 странами, каждая из которых имеет различные культурные, экономические и социальные аспекты. Несмотря на то, что в рамках ЛАТАМ удалось улучшить многоплановый уход за больными склерозом (МС), все еще предстоит решить ряд проблем. Эпидемиологические исследования показали различные показатели распространенности НР в регионе под влиянием таких факторов, как генетика, экологические условия и региональное разнообразие. Расширились научные исследования по вопросам MS в LATAM, появились публикации и консенсусные руководящ

Совпадение в аннотации оригинала
Latin America (LATAM) is a diverse region with more than 30 countries, each varying in cultural, economic, and social aspects. While multiple sclerosis (MS) care in LATAM has improved, there are still challenges to address. Epidemiologic studies have shown varying incidence rates of MS in the region, influenced by factors such as genetics, environmental cond…

Degenerative Spine Disorders and Multiple Sclerosis.

Multiple sclerosis (MS) is an autoimmune inflammatory disease that results in demyelination of the central nervous system (CNS). MS affects as many as 350,000 individuals in the United States and commonly presents before the age of 45 years. Patients with MS, as the general population, are likely to encounter degenerative changes of the spine as they age, and this can pose a unique challenge to both patients with MS and physicians, as both conditions can have a great deal of symptomatic overlap despite stark differences in management. Currently there is no definitive approach that allows physi…

Epstein-Barr virus and multiple sclerosis.

Epstein-Barr virus (EBV) is a ubiquitous human lymphotropic herpesvirus with a well-established causal role in several cancers. Recent studies have provided compelling epidemiological and mechanistic evidence for a causal role of EBV in multiple sclerosis (MS). MS is the most prevalent chronic inflammatory and neurodegenerative disease of the central nervous system and is thought to be triggered in genetically predisposed individuals by an infectious agent, with EBV as the lead candidate. How a ubiquitous virus that typically leads to benign latent infections can promote cancer and autoimmune …