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Влияние возраста на диагностику, лечение и прогноз в педиатрическом многократном склерозе: многоцентровое исследование из Турции.

ЦЕЛЬ: Оценка демографических и клинических характеристик ПОМС в Турции и изучение влияния возраста на начало периода на прогноз. Множественный склероз (MS) является хроническим имунизированным заболеванием центральной нервной системы, которое в основном затрагивает взрослых. Вместе с тем 3-5% случаев начинаются до достижения 18-летнего возраста, определяемого как педиатрический MS (POMS). В ПОМС часто представлены более высокие показатели рецидивов и различные клинические модели по сравнению с заболеваниями взрослых. МЕТОДЫ: Данные семи центров МЗ в Турции были ретроспективно рассмотрены. Вклю

Совпадение в аннотации оригинала
OBJECTIVE: To evaluated demographic and clinical characteristics of POMS in Turkey and examined the impact of age at onset on prognosis. BACKGROUND: Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system that mainly affects adults. However, 3-5 % of cases begin before age 18, defined as pediatric-onset MS (POMS). POMS oft…

FABP7 увеличивается в прогрессивном множественном склерозе и вызывает про-воспалительный фенотип в моноцитах с помощью гликолитического переключателя.

Множественный склероз (MS) включает дисрегулирование врожденных иммунных клеток, включая моноциты, особенно в прогрессивных MS. Протеины, связывающие жирную кислоту, имеют важное значение для переноса жирной кислоты и метаболизма в различных клетках. FABP7, мозг-FABP, поддерживает метаболическую функцию в астроцитах и нейронных стволовых клетках, но влияние FABP7 на моноциты неизвестно. Здесь мы находим повышенный уровень FABP7 в сыворотке и цереброспинарной жидкости пациентов со вторичным прогрессивным MS. Повышенные уровни сыворотки FABP7 позитивно коррелируют с более высокими показателями и

Совпадение в аннотации оригинала
Multiple sclerosis (MS) involves dysregulation of innate immune cells including monocytes, especially in progressive MS. Fatty acid binding proteins (FABP) are essential for fatty acid transport and metabolism in multiple cell types. FABP7, a brain-FABP, maintains metabolic function in astrocytes and neural stem cells, but the effect of FABP7 on monocytes is…

Cerebellar repetitive transcranial magnetic stimulation combined with physiotherapy for balance in people with multiple sclerosis: A randomized controlled trial with six-week follow-up.

BACKGROUND: Among neurological disorders, multiple sclerosis (MS) is the most commonly encountered in young adults, causing significant disability particularly balance impairments. Various strategies like physiotherapy and repetitive transcranial magnetic stimulation (rTMS) have been explored to improve balance in people with MS (PwMS). This study aimed to evaluate the effects of cerebellar high-frequency rTMS combined with physiotherapy on balance in PwMS. METHODS: Thirty ataxic participants with MS, including both sexes with relapsing-remitting or secondary progressive MS, were randomly ass…

Dynamic walking features and improved walking performance in multiple sclerosis patients treated with fampridine (4-aminopyridine).

BACKGROUND: Impaired walking capacity is a frequent confinement in Multiple Sclerosis (MS). Patients are affected by limitations in coordination, walking speed and the distance they may cover. Also abnormal dynamic walking patterns have been reported, involving continuous deceleration over time. Fampridine (4-aminopyridine), a potassium channel blocker, may improve walking in MS. The objective of the current study was to comprehensively examine dynamic walking characteristics and improved walking capacity in MS patients treated with fampridine. METHODS: A sample of N = 35 MS patients (EDSS me…

CSF oligoclonal band status informs prognosis in multiple sclerosis: a case control study of 100 patients.

OBJECTIVE: Oligoclonal band (OCB) negative multiple sclerosis (MS) is well recognised but uncommon, studied in only a few usually small case series. These reached differing conclusions on whether its clinical features or course differ from OCB positive disease. The study hypothesis was that a definitive study would not only be of clinical and prognostic value but also potentially offer information about the possible role of CSF oligoclonal immunoglobulins in MS disease processes. METHODS: A collaborative cohort of well documented patients in southwest England and south Wales was used to ident…

The presence of a paramagnetic phase rim in multiple sclerosis is linked to lesion age: An exploratory study.

BACKGROUND: In relapsing-remitting multiple sclerosis (RRMS), smouldering inflammation at the rims of chronic active lesions is increasingly recognised as a key driver of disease progression. Paramagnetic rim lesions (PRLs), detected using susceptibility-weighted imaging, have emerged as a potential biomarker of this chronic inflammatory activity. However, their clinical relevance and relationship to lesion-specific features such as size and age remain poorly understood. OBJECTIVE: To investigate the association between PRL presence and clinical/radiological measures of disease progression, a…

Atypical facial pain in multiple sclerosis caused by spinal cord seizures: a case report and review of the literature.

BACKGROUND: Pain is a very commonly reported symptom and often drives patients to seek medical attention; however, it can prove a very difficult diagnostic conundrum and even more challenging to treat effectively. Accurately determining the primary pain generator is key, as certain conditions have efficacious medical and surgical treatments. We present a rare case of a man with multiple sclerosis presenting with spinal cord seizures causing dermatomal pain. While pain has been reported in the context of motor symptoms attributed to spinal cord seizures in a small number of spinal cord conditio…

Efficacy and safety of a bodyweight-adjusted higher dose of ocrelizumab in relapsing (MUSETTE) and primary progressive (GAVOTTE) multiple sclerosis: two multicentre, randomised, double-blind, parallel-group phase 3b trials.

BACKGROUND: Ocrelizumab is a humanised anti-CD20 monoclonal antibody approved for people with relapsing (RMS) or primary progressive multiple sclerosis (PPMS). In a post-hoc analysis of phase 3 trials in RMS and PPMS using a 600 mg dose, higher exposure to ocrelizumab was associated with greater B-cell depletion and lower risk of confirmed disability progression. Here, we prospectively assessed the efficacy and safety of a high dose of ocrelizumab in patients with RMS or PPMS. METHODS: Two multicentre, double-blind, phase 3 controlled trials were conducted to compare high-dose ocrelizumab wit…

Краткосрочные и долгосрочные последствия раннего и отсроченного лечения ослелизумаба для потери мозжечка у пациентов с RMS и PPMS.

Мозговой мозг представляет собой функционально и анатомически сложную структуру, на которую при множественном склерозе (MS) влияют повреждения фокусных белых/грайных материй и вторичное нейродегенерирование разрозненных/различных соединений с надтенторным мозгом и спинным мозгом. ЦЕЛИ: Оценка эффективности ocrelizumab в сравнении с интерфероном β-1a (IFN β-1a)/местоположением в отношении потери объема головного мозга и воздействия перехода на ocrelizumab на изменение объема в ходе испытаний на этапе III при повторном включении MS (RMS, OPERA I/II) и в первичных прогрессивных MS (PPMS, ORATORIO

Совпадение в аннотации оригинала
BACKGROUND: The cerebellum is a functionally and anatomically complex structure, which, in multiple sclerosis (MS), is affected by focal white/gray matter lesions and by secondary neurodegeneration of afferent/efferent connections to the supratentorial brain and the spinal cord. OBJECTIVES: To assess the efficacy of ocrelizumab compared with interferon β-1a…

Focal disturbances in the blood-brain barrier are associated with formation of neuroinflammatory lesions.

Early changes in the normal appearing white matter of multiple sclerosis (MS) patients precede the appearance of gadolinium-enhancing lesions. Although these findings suggest blood-brain barrier (BBB) breakdown as an important feature in MS pathogenesis, limited information is available on the BBB alterations during lesion genesis. Here, we perform a longitudinal characterization of the vascular, neuropathological and immunological changes before lesion formation in mice developing spontaneous relapsing-remitting experimental autoimmune encephalomyelitis (sRR-EAE). We found a significant upreg…

Mapping brain volume change across time in primary-progressive multiple sclerosis.

PURPOSE: Detection and prediction of the rate of brain volume loss with age is a significant unmet need in patients with primary progressive multiple sclerosis (PPMS). In this study we construct detailed brain volume maps for PPMS patients. These maps compare age-related changes in both cortical and sub-cortical regions with those in healthy individuals. METHODS: We conducted retrospective analyses of brain volume using T1-weighted Magnetic Resonance Imaging (MRI) scans of a large cohort of PPMS patients and healthy subjects. The volume of brain parenchyma (BP), cortex, white matter (WM), dee…

MicroRNAs as disease progression biomarkers and therapeutic targets in experimental autoimmune encephalomyelitis model of multiple sclerosis.

Multiple sclerosis is an autoimmune neurodegenerative disease of the central nervous system characterized by pronounced inflammatory infiltrates entering the brain, spinal cord and optic nerve leading to demyelination. Focal demyelination is associated with relapsing-remitting multiple sclerosis, while progressive forms of the disease show axonal degeneration and neuronal loss. The tests currently used in the clinical diagnosis and management of multiple sclerosis have limitations due to specificity and sensitivity. MicroRNAs (miRNAs) are dysregulated in many diseases and disorders including d…

Therapeutic effects of estrogens on inflammatory demyelination in a mouse model of multiple sclerosis.

Multiple Sclerosis (MS) is a neurodegenerative autoimmune disease in which the immune system targets the myelin sheath of nerve axons, leading to a variety of neurological signs. Sex hormones are thought to be important factors in MS since pregnancy and oral contraceptives reduce both symptoms and relapses. During pregnancy, remissions occur primarily in the third trimester when estradiol and estriol are elevated. We have investigated the role of these two hormones in an experimental model of virus-induced MS. Theiler's murine encephalomyelitis virus (TMEV) causes an inflammatory demyelinating…

Chronic lesion expansion as an imaging biomarker in multiple sclerosis.

The pathophysiological processes that drive disability progression in multiple sclerosis (MS) are not adequately captured by clinically available imaging biomarkers. Slowly expanding lesions (SELs) are a novel magnetic resonance imaging (MRI) biomarker proposed to reflect histopathologically defined chronic active lesions, which are associated with disease progression. SELs are identified through complex MRI analysis pipelines that measure volume changes in chronic MS lesions across serial MRI scans. This review provides a comprehensive overview of SELs, covering their proposed histopathologic…

Strategies for protecting oligodendrocytes and enhancing remyelination in multiple sclerosis.

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) characterized by encephalitogenic leukocyte infiltration and multifocal plaques of demyelination. Patients present with debilitating clinical sequelae including motor, sensory, and cognitive deficits. For the past 30 years, immune modulating treatments have entered the marketplace and continue to improve in limiting the frequency and severity of relapses, but no cure has been found and no drug has successfully stopped chronic progressive disease. Recent work focusing on the oligodendrocy…

Bilateral optic neuropathy revealing Sjögren's syndrome.

INTRODUCTION: The central nervous system involvement has been reported in 20% of cases of primary Sjogrën's syndrome (SS), a chronic autoimmune disease characterized by a disorder of the exocrine glands secondary to progressive lymphocyte infiltration. Classically described neurological manifestations include sensorimotor deficits, aseptic meningitis or meningoencephalitis, multiple sclerosis-like syndromes and myeolopathies. OBSERVATION: We report here the case of a 53-year-old woman who exhibited rapidly progressive visual loss, disclosing bilateral optic neuropathy, as an uncommon initial …

Limiting multiple sclerosis related axonopathy by blocking Nogo receptor and CRMP-2 phosphorylation.

Multiple sclerosis involves demyelination and axonal degeneration of the central nervous system. The molecular mechanisms of axonal degeneration are relatively unexplored in both multiple sclerosis and its mouse model, experimental autoimmune encephalomyelitis. We previously reported that targeting the axonal growth inhibitor, Nogo-A, may protect against neurodegeneration in experimental autoimmune encephalomyelitis; however, the mechanism by which this occurs is unclear. We now show that the collapsin response mediator protein 2 (CRMP-2), an important tubulin-associated protein that regulates…

Foamy microglia link oxylipins to disease progression in multiple sclerosis.

Multiple sclerosis (MS) is a chronic neuroinflammatory disease in which demyelinating white matter lesions accumulate and expand, driving irreversible disability. Here we identify a distinct population of foamy GPNMB+ microglia/macrophages associated with lesion expansion in secondary progressive MS. Using integrated lipidomic, transcriptomic, proteomic, chemical proteomic and histological analyses of human postmortem MS lesions, we show that lesions containing foamy microglia/macrophages exhibit disrupted lipid metabolism, lysosomal stress and markers associated with heightened phagocytosis a…

Эффективность когнитивных испытаний и прогрессирование заболеваний в первичных и вторичных прогрессивных MS: анализ исследования SPRINT-MS.

Клинические испытания методов лечения сканирующих заболеваний (ДМТ) на множественный склероз (МЗ) все чаще включают когнитивные результаты, хотя воздействие ДМТ на когнитивное сознание остается неизвестным. МЕТОДЫ: В ходе этого вторичного анализа данных, полученных из SPRINT-MS, стадия 2, случайная, контролируемая плацебопроба ибюдиласта для прогрессивных MS, мы провели оценку эффективности испытания с использованием символических дигитов (SDMT) и выборочного напоминающего теста (SRT) в отношении физических недостатков, объема мозга, оцениваемого с помощью магнитного резонансного изображения,

Совпадение в аннотации оригинала
BACKGROUND: Clinical trials of disease-modifying therapies (DMTs) for multiple sclerosis (MS) increasingly incorporate cognitive outcomes, although effects of DMTs on cognition remain unknown. METHODS: In this secondary analysis of data from SPRINT-MS, a phase 2 randomized, placebo-controlled trial of ibudilast for progressive MS, we evaluated performance o…

A secondary progressive clinical course is uncommon in neuromyelitis optica.

We compared the clinical course of 96 patients with neuromyelitis optica (NMO) to multiple sclerosis (MS) natural history data. Based on the distribution of follow-up data (median 6.1 year), we estimated that 21 NMO patients would convert to a secondary progressive course, but we observed only two conversions (p = 0.00002; relative risk = 0.08). The disparate natural histories of MS and NMO suggest dissociation between relapses and clinical progression in CNS demyelinating diseases.