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A Healthcare-Associated Infection With Monkeypox Virus of a Healthcare Worker During the 2022 Outbreak.

This article describes a case of healthcare-associated monkeypox infection in France during the 2022 outbreak. A female medical resident accidently pricked herself with a soiled subcutaneous needle used to harvest a vesicle of a patient infected by monkeypox virus and developed 4 days later a unique skin lesion, positive for monkeypox virus.

A review of experimental and natural infections of animals with monkeypox virus between 1958 and 2012.

Monkeypox virus (MPXV) was discovered in 1958 during an outbreak in an animal facility in Copenhagen, Denmark. Since its discovery, MPXV has revealed a propensity to infect and induce disease in a large number of animals within the mammalia class from pan-geographical locations. This finding has impeded the elucidation of the natural host, although the strongest candidates are African squirrels and/or other rodents. Experimentally, MPXV can infect animals via a variety of multiple different inoculation routes; however, the natural route of transmission is unknown and is likely to be somewhat s…

Using remote sensing to map the risk of human monkeypox virus in the Congo Basin.

Although the incidence of human monkeypox has greatly increased in Central Africa over the last decade, resources for surveillance remain extremely limited. We conducted a geospatial analysis using existing data to better inform future surveillance efforts. Using active surveillance data collected between 2005 and 2007, we identified locations in Sankuru district, Democratic Republic of Congo (DRC) where there have been one or more cases of human monkeypox. To assess what taxa constitute the main reservoirs of monkeypox, we tested whether human cases were associated with (i) rope squirrels (Fu

A human infection caused by monkeypox virus in Basankusu Territory, Democratic Republic of the Congo.

This paper presents clinical and epidemiological information on a patient with smallpox-like disease, from whom a monkeypox-like virus was isolated. The patient was the first recognized human monkeypox case in medical history.

Разработка мультиплекса в режиме реального времени для одновременного обнаружения обезьянопоксовых клинков I, II и вируса козла.

ВВЕДЕНИЕ: носители вируса обезьяны (MPXV) представляют множество видов с риском межвидовой передачи. Это явление создает угрозу для незарегистрированных домашних животных и повышает опасность для здоровья людей. Клиническая диагностика по-прежнему сталкивается с проблемами, связанными с спецификой оксивирусов. Для укрепления нашего потенциала в области профилактики заболеваний, борьбы с ними и эпидемиологического исследования крайне необходима быстрая и точная оценка, позволяющая проводить различие между клапами I и II MPXV, а также вирусом котпокса (GTPV).Для удовлетворения этой потребности м

Совпадение в аннотации оригинала
INTRODUCTION: Monkeypox virus (MPXV) hosts are of multiple species, with a risk of cross-species transmission. This phenomenon poses a threat to unreported affected domestic animals and increases the risk to human public health. Clinical diagnostics continue to face challenges regarding specificity among poxviruses. The need for a rapid and precise assay to …

A systematic review to identify novel clinical characteristics of monkeypox virus infection and therapeutic and preventive strategies to combat the virus.

Since May 2022, there has been a global increase in the number of Mpox virus (MPXV) cases in countries that were previously considered non-endemic. In July 2022, the World Health Organization (WHO) declared this outbreak a public health emergency of international concern. The objective of this systematic review is to examine the novel clinical features of Mpox and to assess the available treatment options for managing the disease in patients who are afflicted with it. We conducted a systematic search in several databases, including PubMed, Google Scholar, Cochrane Library, and the grey literat

Monkeypox Virus Infection Stimulates a More Robust and Durable Neutralizing Antibody Response Compared to Modified Vaccinia Virus Ankara Vaccination.

Monkeypox virus (MPXV) has recently caused a global disease outbreak in humans. Differences in the neutralizing antibody response to vaccination versus MPXV infection remain poorly understood. Here, we examined the neutralization of MPXV and vaccinia virus by sera from a cohort of convalescent and vaccinated individuals at 1 and 8 months postexposure. Convalescent individuals displayed higher neutralizing antibody titers against MPXV than vaccinated and MPXV-naive persons at 1 month postexposure. Neutralizing antibody titers had waned significantly in both groups at 8 months. This study sugges…

IC-ELISAs for the quantitative detection of monkeypox virus cross-immunogenic modified vaccinia virus Ankara antigens L1 and A33.

Vaccination is always the most effective approach to control and prevent monkeypox epidemics. The efficacy testing of vaccines is an importa … nd A33 proteins of the modified vaccinia virus Ankara (MVA) vaccine, which are cross-immunogenic to monkeypox virus (MPXV), respectively. M1-IC-ELISA was shown to be linear over the range of 31.25-2000 ng/mL with an LOD value of 48.36 ng/mL. A35-IC-ELISA was shown to be linear over the range of 3.90-1000 ng/mL with an LOD value of 3.74 ng/mL. These two methods we …

First Comprehensive Global Bibliometric Analysis of Monkeypox Virus Research Landscape From 1976 to 2025.

BACKGROUND: Six decades have elapsed since the index case of monkeypox virus (MPXV) was reported. Unlike most DNA viruses characterized by slow mutation and spread, MPXV caused the global outbreak of 2022, and as expected, several studies prior and post the 2022 outbreak have emanated. Despite its ability to trigger a potential pandemic, there is no holistic quantitative and qualitative insight into MPXV research landscape globally. METHODS: Following the Scientific Procedures and Rationales for Systematic Literature Review (SPAR-4-SLR protocol) applied to the Scopus database, studies were re…

Draft genome of Orthopoxvirus monkeypox virus hMpxV/Uganda/MUWRP-H1922SL/2025 detected in Uganda.

Mpox virus from Clade I exhibits high virulence and poses significant mortality risks, especially among children. We isolated a strain of the mpox virus (hMpxV/Uganda/MUWRP-H1922SL/2025) from an adult woman in Uganda. Using phylogenetic tree analysis and PoxServer evaluation, we determined that this strain belongs to Clade/Lineage Ib.

Antifolate agent aminopterin demonstrates potent anti-monkeypox virus activity in vitro and in vivo.

UNLABELLED: The ongoing spread of the monkeypox outbreak underscores the urgent need for the development of effective therapeutics against the monkeypox virus (MPXV). Aminopterin is a classical antifolate agent known for its anti-tumor activity through the inhibition of folate metabolism. Here, aminopterin was identified as an effective anti-MPXV agent. It significantly inhibited MPXV replication, unlike other antifolate agents such as methotrexate, pemetrexed, and LSN3213218. In Vero E6 cells, the half-maximal inhibitory concentration (IC₅₀) was 36.10 nM, the half-cytotoxic concentration (CC₅…

DMSO enhanced one-pot HDA-CRISPR/Cas12a biosensor for ultrasensitive detection of Monkeypox virus.

We present a dimethyl sulfoxide (DMSO)-enhanced one-pot HDA-CRISPR/Cas12a biosensor for the ultrasensitive detection of the monkeypox virus (MPXV). The MPXV B6R gene was initially amplified using DMSO-enhanced helicase-dependent amplification (HDA) in the bottom of the reaction tubes. DMSO was employed to enhance the amplification efficiency of HDA. CRISPR/Cas12a reagents, pre-added to the caps of the reaction tubes, were subsequently combined with HDA products to generate fluorescence signals. This DMSO-enhanced HDA-CRISPR/Cas12a biosensor enables the detection of synthetic B6R DNA within 1 h…

Real-Time Use of Monkeypox Virus Genomic Surveillance, King County, Washington, USA, 2022-2024.

A monkeypox virus genomic surveillance pilot began in King County, Washington, USA, during the 2022 outbreak. Genomic surveillance proved critical in determining local versus international exposure of a case where no known exposures were identified by interview, illustrating the value of genomics in case investigation and public health practice.

Nosocomial transmission in a monkeypox virus clade Ib outbreak, Ireland, August to October 2025.

In August-October 2025, an mpox outbreak with monkeypox virus clade Ib was identified in Ireland, involving four epidemiologically linked cases. The cluster originated from a traveller returning from Pakistan via the United Arab Emirates and includes a nosocomial infection. Phylogenetic analysis revealed genetic clustering with an Omani sequence, suggesting Eastern Mediterranean Region transmission routes. This outbreak underscores the importance of clinical vigilance, rapid molecular diagnostics and coordinated public health responses to prevent onward clade Ib transmission in non-endemic cou…

Emergence and evolution of monkeypox virus: Epidemiology, pathology, clinical symptoms, preventative and treatment measures.

As the COVID-19 pandemic situation was on an end, a new monkeypox menace has been discovered in several places of the world. The most comfor … , and response to antiviral medicine. This review offers important insights on the evolution of the monkeypox virus and its different modes of transmission. It also discusses epidemiology, clinical findings, management, challenges, and current strategies for the disease, as well as the implications of the current epidemic on public health. Comprehensive research …

Awareness of monkeypox virus among sexual medicine experts is low: a multi-institutional survey.

An international outbreak of Monkeypox (mpox), a zoonotic orthopox virus, was confirmed by the World Health Organization in May 2022. The outbreak represented the first sustained community transmission of mpox beyond West or Central Africa, with speculated causes including declining smallpox vaccination rates, increased international travel, expanding populations, and sexual interactions. This study aimed to assess the understanding and recognition of mpox among sexual medicine experts including the identification of pertained genital lesions. An anonymous electronic survey was developed, addr

Elucidating the evolution of monkeypox virus genomes through phylo-geo-network and haplogroup analysis.

BACKGROUND: As the world settles down from the COVID-19 pandemic, many countries are faced with an unexpected outbreak of monkeypox infection. Monkeypox is a zoonotic disease caused by monkeypox virus (MPXV), which is an enveloped, double stranded DNA virus belonging to the Poxviridae family. Presently, we construct and analyze the phylo-geo-network and the corresponding haplogroups. Presently, we performed the haplogroup analysis with their defining mutations and phylogenetic lineage study along with geographical distributions with the aim to understand the evolutionary path of the MPXV acros…