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Drainage of Suprachoroidal Fluid Using Silicone Oil Tamponade in Rhegmatogenous Retinal Detachment with Choroidal Detachment.

PURPOSE: To evaluate a novel silicone oil-assisted technique for managing rhegmatogenous retinal detachment with choroidal detachment (RRDCD), addressing the challenges of incomplete suprachoroidal drainage and postoperative tamponade insufficiency. METHODS: Twelve consecutive RRDCD eyes underwent vitrectomy with controlled silicone oil injection combined with quadrant-by-quadrant sclerotomy compression. The standardized protocol included: (1) pars plana BSS injection for stabilization; (2) 23/25-gauge trocar placement in shallowest quadrants; (3) lighted pick-assisted cannula positioning; an…

Retinal and Choroidal Vascular Alterations in Carotid Dissection Versus Atherosclerosis: Insights Into Divergent Ischemic Mechanisms.

BACKGROUND: To contrast retinal and choroidal vascular alterations between carotid artery dissection (CAD) and carotid artery stenosis (CAS), and analyze their associations with cerebral infarction patterns and stenosis severity. METHODS: This observational study included stenotic-degree-matched patients with CAD and patients with CAS. Retinal ischemic signs-cotton wool spots, retinal artery occlusion, and paracentral acute middle maculopathy-were evaluated using fovea-centered optical coherence tomography/angiography. Retinal vascular density and choroidal metrics (choriocapillaris density, …

Case Report: Vision-threatening manifestations of choroidal osteomas and papilloedema in presumed Camurati-Engelmann disease.

Camurati-Engelmann Disease (CED) is a rare sclerosing bone dysplasia in which skull-base hyperostosis may result in neuro-ophthalmic complications. We report a 21-year-old woman with presumed CED and known bilateral choroidal osteomas who presented with bilateral optic nerve swelling. Neuroimaging demonstrated diffuse cranial hyperostosis with optic canal narrowing but no definitive optic nerve compression or venous sinus thrombosis. Lumbar puncture confirmed raised intracranial pressure with an opening pressure of 33 cm H₂O. Optical coherence tomography revealed right eye subretinal fluid wit…

Vortex Vein Morphology and Choroidal Thickness as Predictors of Refractive Status: Model Construction and Mediation Analysis.

PURPOSE: The purpose of this study was to investigate how vortex vein geometry and choroidal structure relate to refractive status and to develop an internally validated prediction framework based on these posterior segment features. METHODS: A cross-sectional study was conducted on 147 participants, including 49 with myopic eyes, 49 with emmetropic eyes, and 49 with hyperopic eyes. Participants were young adults aged approximately 18 years, and axial length (AL) ranged from 23.19 ± 0.09 mm in hyperopic eyes to 24.92 ± 0.30 mm in myopic eyes. All participants underwent multimodal imaging, inc…

Quantitative evaluation of choroidal thickness and vascularity in subclinical keratoconus: a cross-sectional EDI-OCT study.

PURPOSE: To assess choroidal thickness (CT) and choroidal vascularity index (CVI) in a subclinical keratoconus (SK) population. METHODS: A prospective, cross-sectional analysis was performed on 42 participants of unilateral keratoconus (KC), defined by clinical keratoconus (CK) in one eye and SK in the contralateral eye along with 42 age- and sex-matched healthy control participants. CT measurements were obtained at the subfoveal, nasal 750 µm (N750), and temporal 750 µm (T750) locations. Measurements of CVI, luminal area (LA), stromal area (SA), and total choroidal area (TCA) were calculated…

Choroidal vascularity profiles in diabetic macular oedema subtypes: a swept-source OCT angiography study.

OBJECTIVES: To characterise choroidal microvascular changes in diabetic macular oedema (DMO) subtypes using swept-source optical coherence tomography angiography (SS-OCTA). METHODS: This cross-sectional study analysed 182 eyes with centre-involved DMO from 141 patients (45 diffuse retinal thickening [DRT], 72 cystoid macular oedema [CMO], 65 serous retinal detachment [SRD]) and 40 age-matched healthy controls. Imaging was performed using the VG200 SS-OCTA system with a 1050 nm wavelength and 200,000 A-scans/second scan speed. Parameters including choroidal thickness (ChT), choroidal volume (C…

Structural Retinal and Choroidal Changes in Toxoplasmic Retinochoroiditis Assessed by Swept-Source Optical Coherence Tomography.

PURPOSE: To demonstrate retinal and choroidal structural changes across distinct disease activity phases in toxoplasma retinochoroiditis (TRC) using swept-source optical coherence tomography (SS-OCT) and establishing stage-specific imaging biomarkers for therapeutic decisions and monitoring. METHODS: Retrospective analytical study of 33 patients (39 eyes) with TRC (2017-2024) at a tertiary uveitis clinic. Eyes categorized as active (n = 5), reactive (n = 13), or inactive (n = 27) using standardized clinical/serological criteria. SS-OCT measured central foveal thickness (CFT), subfoveal choroi…

Острый ретинальный некроз с хороидальным воспалением, оптическим перинеритом и ранним отсечением ретинальной части: доклад по делу.

ВВЕДЕНИЕ: Цель исследования состояла в том, чтобы описать редкое представление острого некроза сетчатки (ARN) у иммунокомпетентного взрослого человека с хромоидальным, оптическим нервым и орбитальным воспалением с экссудационным отсеком сетчатки (ERD), что осложняется ранним отсеком сетчатки (RRD). Это ретроспективный доклад о нетипичной АРН. Был проведен обзор клинических данных, лабораторных испытаний и мультимодальных изображений. КИСЛОТА: В ходе обследования был обнаружен грануломатозный пануэит правого глаза, включая грануломатное воспаление передних камер, плотную витреную темноту и пери

Совпадение в аннотации оригинала
INTRODUCTION: The aim of the study was to describe a rare presentation of acute retinal necrosis (ARN) in an immunocompetent adult, with choroidal, optic nerve, and orbital inflammation with exudative retinal detachment (ERD), complicated by early rhegmatogenous retinal detachment (RRD). This is a retrospective case report of atypical ARN. Clinical data, lab…

Recurrence timing and visual outcomes of recurrent myopic choroidal neovascularization after anti-VEGF therapy.

PURPOSE: To compare clinical characteristics and visual outcomes according to recurrence timing in eyes with myopic choroidal neovascularization (CNV) following anti-vascular endothelial growth factor (anti-VEGF) therapy. METHODS: This retrospective cohort study included eyes with treatment-naïve myopic CNV that achieved complete resolution after initial anti-VEGF therapy. To specifically evaluate the impact of recurrence timing, analyses were restricted to eyes that developed recurrence, which were categorized as early (< 12 months) or late (≥ 12 months). Baseline characteristics, multimodal…

Late Diagnostic Revision to Tubercular Choroiditis in Patients with Recurrent APMPPE: A Retrospective Study in 28 Cases.

PURPOSE: To investigate recurrence patterns of acute posterior multifocal placoid pigment epitheliopathy (APMPPE) and its diagnostic revisio … h corticosteroids. However, five were reclassified as ocular TB based on lesion morphology (four as choroidal granuloma and one as serpiginous-like choroiditis) and positive TB tests, and all resolved with a combination of anti-TB therapy (ATT) with or without corticosteroids. Except for one, no recurrences were observed after ATT, with a median follow-up …

PLASMA CIRCULATING TUMOR DNA TO ASSIST IN THE DIAGNOSIS OF UNKNOWN PRIMARY MALIGNANCY UNDERLYING CHOROIDAL METASTASES.

PURPOSE: Management of suspected choroidal metastases requires diagnostic imaging and an invasive, sometimes intraocular, biopsy to determine the primary malignancy. This multistep process takes time, which may affect morbidity and mortality. METHODS: This was a retrospective review of one case. RESULTS: A 56-year-old woman presented with bilateral amelanotic choroidal masses suspicious for metastases of unknown origin. Plasma circulating tumor DNA revealed EGFR , PTEN , and SMAD4 , a profile consistent with non-small-cell lung cancer. Subsequent radiographic imaging and scapular biopsy reve…

Assessment of interocular symmetry of choroidal vascularity index and thickness in patients with systemic sclerosis: a prospective study.

PURPOSE: Systemic sclerosis (SSc) affects blood vessels, internal organs, and skin. In ophthalmology, SSc impacts the choroid. The choroidal vascularity index (CVI) measures the vascular component of the choroid and may serve as a biomarker for the disease staging and prognosis. Studies have reported reduced choroidal thickness and altered CVI in SSc, which supports the theory of vascular damage. This study aimed to examine interocular symmetry in choroidal parameters among SSc patients. It has provided the insight into the disease symmetry and assessed the representativeness of examining one …

Choroidal melanoma patient views on the importance of treatment characteristics and outcomes, and physicians' information provision in the Netherlands.

PURPOSE: To identify the treatment characteristics and outcomes that Dutch patients with large or juxtapapillary choroidal melanoma consider important when choosing between enucleation and proton beam therapy (PBT). We further determined to what extent these treatment characteristics and outcomes are discussed with newly diagnosed choroidal melanoma patients. METHODS: Through a literature search, stakeholder interviews and feedback from patients, we identified 15 treatment characteristics and outcomes that patients might consider important for deciding between enucleation and PBT. Using a ran…

Retinal and choroidal microvasculature and structural analysis in OCTA for refractive amblyopia diagnosis using machine learning.

OBJECTIVE: To evaluate the features of retinal and choroidal microcirculation and structure in patients with amblyopia compared to healthy adolescents of the same age (>10 years old). To classify and diagnose amblyopia using machine learning techniques on optical coherence tomographic angiography (OCTA) images. METHODS: Nineteen adolescents aged 11-17 with hyperopic refractive amblyopia and 22 age-matched healthy controls underwent 12 × 12 mm macular OCTA scans. The eyes were classified into three groups: amblyopic, contralateral non-amblyopic, and control. Retinal thickness (RT), choroidal t…

Pixel Intensity to Estimate Choroidal Tumor Thickness Using 2-Dimensional Ultra-Widefield Images.

IMPORTANCE: Tumor thickness is a well-established risk factor for malignant transformation of choroidal nevus into melanoma. To date, reliable evaluation of tumor thickness relies on B-scan ultrasonography, which is frequently unavailable at nonsubspecialty clinics where most melanocytic choroidal lesions (MCLs) are first diagnosed. OBJECTIVE: To describe a technique for potential rapid and reliable estimation of MCL thickness using only Optomap ultra-widefield (UWF) images without B-scan ultrasonography. DESIGN, SETTING, AND PARTICIPANTS: This retrospective, exploratory, cross-sectional ana…

Diabetic foveal neovascularization is associated with diminished subfoveal choroidal flow on optical coherence tomography angiography.

OBJECTIVE: To evaluate the role of retinal and choriocapillaris blood flow in the development of diabetic foveal neovascularization (DFN) us … 0.01). SCP and DCP AFI were not statistically significant. CONCLUSIONS: Our findings suggest that choroidal hypoperfusion may be a potential driving factor for the development of DFN. The detection of these changes in the smaller scans of the total and subfoveal areas suggests a rather exaggerated and localized subfoveal distribution of ischaemia. Large …

To Quantitatively Assess and Compare Choroidal and RNFL Thickness in Patients with Active and Inactive Thyroid Eye Disease.

INTRODUCTION: Thyroid eye disease (TED) can be classified into an active phase with rapid progression and an inactive phase with symptom stabilization. Recent studies found a higher choroidal thickness in patients with active TED. Less is known about the effect of disease on the retina. More extensive study is warranted for generalizing the role of choroidal thickness as a biomarker for disease severity. The study aims to investigate the correlation between the subfoveal choroidal and circumpapillary retinal nerve fibre layer (cp RNFL) thickness with the severity of the disease. TED. METHODS:…

Six-year findings of polypoidal choroidal vasculopathy in the EVEREST II study: Japanese subgroup analysis.

PURPOSE: To evaluate long-term outcomes for polypoidal choroidal vasculopathy (PCV) in Japanese patients in the EVEREST II study. STUDY DESIGN: A multicenter, cross-sectional study of the long-term outcomes of a cohort of patients originally treated with ranibizumab alone (monotherapy group) or in combination with photodynamic therapy PDT (combination group) in the EVEREST II study (ClinicalTrials.gov identifier, NCT01846273). METHODS: Ninety participants from the six-year EVEREST II follow-up: 20 Japanese and 70 non-Japanese were included. Long-term changes in best-corrected visual acuity (…

Assessment of choroidal melanoma and nevus lesions using ultrasound vibro-elastography and parametric imaging approach.

The purpose of this study was to assess eye lesions by analyzing wave speed (WS) of lesions using ultrasound vibro-elastography (UVE) together with a parametric ultrasound imaging approach. Ten subjects with eye lesions (5 nevus (N) vs. 5 melanoma (M)) were recruited and tested using UVE. In addition, the sliding window method was used to reconstruct and analyze horizontal Normalized Shannon Entropy (hNSE) images and Nakagami-m/omega images. Two-way ANOVA statistical analysis was performed to compare mean values of the contrast to noise ratio (CNR), hNSE, and m/omega of these images between th

Prognostic factors in the treatment of polypoidal choroidal vasculopathy with conbercept: a post hoc analysis of the STAR study.

BACKGROUND: A post hoc analysis of the STAR study, which was a 48-week, phase IV, multicenter randomized controlled multicenter clinical trial was performed. This study aims to identify the baseline factors associated with visual and anatomic changes over 48 weeks in the treatment of active polypoidal choroidal vasculopathy (PCV) with conbercept. METHODS: In the STAR study, 249 participants were randomized to either the 3 + Q12W (3 monthly injections followed by injections every 12 weeks) or 3 + TAE (3 monthly injections followed by treat and extend regimen) group. The association of 27 basel…