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Hemochromatosis osteoarthritis.

Hemochromatosis-associated arthropathy is a progressive degenerative joint disease characterized by iron-overload related pathological changes. While it may involve episodic inflammatory flares, it is primarily defined by bone and cartilage destruction rather than persistent chronic synovitis. It is typically classified as either spontaneous or secondary. This condition is often accompanied by various clinical manifestations, including liver disease, cardiomyopathy, skin pigmentation changes, diabetes mellitus, erectile dysfunction, and hypothyroidism. Diagnosis typically relies on a combinati…

Obesity and male infertility - a tenuous relationship: Facts discerned for the busy clinicians.

Obesity is a common health problem affecting over a third of the population worldwide. Obesity has been correlated with many diseases, including cardiovascular disorders, diabetes, cancer, brain degeneration, and premature aging. In men, obesity can also cause issues like erectile dysfunction, poor sperm quality, and prostate problems. Factors like high insulin levels, chronic inflammation, and oxidative stress may play a role in how obesity affects male fertility. Obesity can disrupt the male reproductive system by changing hormone levels, affecting sperm production, and causing problems with…

[Penile Fracture in Japan Resulting from a Habit of Over 30 Years Resembling "Taqaandan"].

A 52-year-old man presented to our hospital with penile swelling and pain. The patient was injured when he forcibly bent his erect penis and heard a dull sound different from the"usual click sound"in the morning. His penis was bent dorsally with a hematoma and was purplish red. We diagnosed this as penile fracture and performed surgical treatment. We made a circumferential incision and degloved his penile prepuce. We removed the hematoma and repaired the injured tunica albuginea with absorbable sutures. Urethral injury was not found. He had no complications or erectile dysfunction after surger…

Discovery and Optimization of Dihydroquinolin-2(1H)-ones as Novel Highly Selective and Orally Bioavailable Phosphodiesterase 5 Inhibitors for the Treatment of Pulmonary Arterial Hypertension.

Phosphodiesterase 5 (PDE5) is a cGMP-specific hydrolytic enzyme and widely distributed in versatile tissues. PDE5 has been identified as a valid therapeutic target for treating erectile dysfunction and pulmonary arterial hypertension (PAH). Herein, a hit-to-lead structural optimizations were performed on the PDE1 inhibitor 10c, leading to compound 14b possessing great potency against PDE5A (IC50 = 3 nM) with high selectivity over PDE1, PDE2, PDE3, PDE4, PDE7, PDE8, PDE9, PDE10, and PDE11 by more than 1125-fold, and remarkable safety properties. Furthermore, oral administration of 14b (5.0 mg/k…

Transbronchial cryobiopsy proven amyloid diffuse cystic lung disease complicating a transthyretin mutated (ATTRm) amyloidosis: a case report.

We present a case report of transbronchial cryobiopsy proven diffuse amyloid cystic lung disease complicating a homozygous Val122Ile (V122I) transthyretin mutated amyloidosis (ATTRm). To the best of our knowledge, this is the first case in the literature reporting such pulmonary lesions in ATTRm amyloidosis, and notably diagnosed through cryobiopsy. A 51-year-old man from Mali with a past medical history of bilateral carpal tunnel syndrome presented erectile dysfunction, asthenia and worsening dyspnoea over the past year. He presented signs of cardiac failure; histological and radiological inv…

The Role of Alpha-lipoic Acid Supplementation in the Prevention of Diabetes Complications: A Comprehensive Review of Clinical Trials.

Alpha-lipoic acid (ALA) is a substantial antioxidant in the prevention of diabetes and diabetes complications. It can regenerate other antioxidants like vitamin E, vitamin C, Coenzyme Q10 and glutathione and is often known as a universal antioxidant. Antioxidants play a role in diabetes treatment due to hyperglycemia-induced stimulation of the polyol pathway and formation of advanced glycation end products (AGE) and reactive oxygen species (ROS). Clinical trials examining alpha-lipoic acid supplementation on diabetic neuropathy, nephropathy, cardiomyopathy and erectile dysfunction display posi…

Молодые мужчины, вступающие в половые отношения с мужчинами, подверженными высокому риску заражения ВИЧ, Бангкокское исследование MSM Cohort, Таиланд, 2006 - 2014 годы.

О высокой распространенности ВИЧ сообщили молодые мужчины, вступающие в половые отношения с мужчинами (ОДМ) в Северной Америке и Западной Европе, однако из Юго-Восточной Азии имеются ограниченные данные, свидетельствующие о том, что МШМ, возможно, являются движущей силой эпидемии ВИЧ в этом регионе. Мы описали распространенность ВИЧ и факторы риска среди 494 ИМСМ, охваченных когортным исследованием в Бангкоке, Таиланд. Показатель заболеваемости ВИЧ составлял 7,4 на 100 человеко-лет. В рамках многовариантного анализа сообщения об использовании эректильного дисфункционального препарата в сочетан

Совпадение в аннотации оригинала
High HIV incidence has been reported in young men who have sex with men (YMSM) in North America and Western Europe, but there are limited da … and. The HIV incidence was 7.4 per 100 person-years. In multivariable analysis, reporting use of an erectile dysfunction drug in combination with club drugs, having receptive or both insertive and receptive anal intercourse with men, having hepatitis A infection, having rectal Chlamydia trachomatis, having hepatitis B infection prior to HIV seroconversion, and reporti …

Targeting phosphodiesterase 5 as a therapeutic option against myocardial ischaemia/reperfusion injury and for treating heart failure.

UNLABELLED: Phosphodiesterase type 5 (PDE5) selectively hydrolyses the second messenger cGMP into 5'-GMP, thereby regulating its intracellular concentrations. Dysregulation of the cGMP-dependent pathway plays a significant role in various cardiovascular diseases. Therefore, its modulation by drugs, such as PDE5 inhibitors, may represent an effective therapeutic approach. There are currently four PDE5 inhibitors available for the treatment of erectile dysfunction: sildenafil, vardenafil, tadalafil and avanafil. Sildenafil and tadalafil have also received Food and Drug Administration approval fo…

Protective effects of seahorse extracts in a rat castration and testosterone-induced benign prostatic hyperplasia model and mouse oligospermatism model.

This study investigated the effects of seahorse (Hippocampus spp.) extracts in a rat model of benign prostatic hyperplasia (BPH) and mouse m … cts have potential as a candidate marine drug for treating BPH without inducing the side effects of erectile dysfunction (ED) or oligospermatism associated with the BPH drug finasteride.

Treatment of dysautonomia associated with Parkinson's disease.

Non-motor symptoms are increasingly recognized to adversely impact on the quality of life of patients with in Parkinson's disease (PD), part … rinary frequency: oxybutynin, tolterodine, solifenacin, darifenacin, botulinum toxin injections; 5. Erectile dysfunction: sildenafil and other phosphodiesterase type 5 inhibitors. More effective symptomatic and pathogenesis-targeted therapies are needed to ameliorate the non-motor symptoms of PD that usually do not respond well to dopaminergic medications.

[Urethral disruption treated by echo guided endoscopic management: a case report].

We report a case of 63-years-old man with a chief complaint of urinary retention and urethral meatal bleeding due to straddle injury. Urological examination revealed proximal bulbous urethral disruption with 1 cm gap, and then cystostomy was placed. Afterwards, urethral disruption was treated by echo guided endoscopic urethroplasty. Transurethral resection of scar tissue was performed twice for postoperative urethral stricture. Postoperative voiding cystourethrography revealed no urethral stricture. The patient voids well without urinary incontinence and erectile dysfunction. Recently, endosco…

The effect of chronic renal failure on phosphodiesterase inhibitor-induced relaxation responses in rabbit cavernosal strips.

Erectile dysfunction is common in men with chronic renal failure. Previously nitrergic and endothelium-dependent relaxation responses have been shown to be reduced in chronic renal failure rabbits. We have therefore investigated the efficacy of phosphodiesterase inhibitors on the corpora cavernosa obtained from uremic rabbits. Uremia was induced with 5/6 nephrectomy and 4 weeks later cavernosal tissue strips were isolated. The relaxant effect of phosphodiesterase 5 inhibitors, zaprinast (1-300 microM) and sildenafil (0.01-300 microM), phosphodiesterase 3 inhibitor amrinone (1-100 microM) and n…

Sexual dysfunctions in patients with well-compensated chronic liver disease: role of etiology, Mediterranean diet and quality of life in an observational cross-sectional study.

BACKGROUND: Sexual dysfunctions (SD) are highly prevalent in Chronic Liver Diseases (CLD). Whether Metabolic dysfunction-Associated Steatoti … red sexual desire/arousal and dyspareunia being the most common complaints, whereas 72.3% males had erectile dysfunction (ED); (2) prevalence of SD was higher in MASLD (89%) than in nonMASLD (64%) (P < 0.001); (3) in females, at univariate analysis, a negative correlation was found between FSFI and age, hypertension, or MASLD; (4) in males, at univariate analysis, IIE …

Couplepause: A New Paradigm in Treating Sexual Dysfunction During Menopause and Andropause.

BACKGROUND: At midlife and beyond, both men and women face organic changes that can affect sexual functioning. For women, ovarian exhaustion causes estrogen deficiency, leading to genitourinary syndrome of menopause, which may include vaginal dryness, irritation/itching, inadequate lubrication, and dyspareunia. Hypoactive sexual desire disorder also can result from biopsychosocial factors. For men, erectile dysfunction prevalence increases with age, and some men develop testosterone deficiency. AIM: In this narrative review, we summarize the literature on how menopause and andropause can affe…

Sustained-release bupropion for selective serotonin reuptake inhibitor-induced sexual dysfunction: a randomized, double-blind, placebo-controlled, parallel-group study.

OBJECTIVE: The authors compared low-dose sustained-release bupropion with placebo for sexual dysfunction induced by selective serotonin reuptake inhibitors (SSRIs). METHOD: Thirty adults who had received SSRIs for at least 6 weeks, who were euthymic, and who had sexual dysfunction as determined by a total score greater than 19 out of a possible 30 on the Arizona Sexual Experience Scale were randomly assigned to receive either 150 mg/day of sustained-release bupropion or placebo at 6:00 p.m. for 3 weeks. RESULTS: There were no significant differences between the sustained-release bupropion an

Improved sexual function in three men taking lamotrigine for epilepsy.

Little information exists about the effects of newer antiepileptic drugs (AEDs) on sexual function in men with epilepsy. We report a series of three male veterans whose sexual disorders improved with lamotrigine. All three had partial seizures. One patient was taking phenobarbital and gabapentin and complained of decreased potency and anorgasmia. After lamotrigine was added for better seizure control and the dosage of gabapentin was tapered, anorgasmia improved. The second patient complained of impotence after a rash while taking phenytoin and carbamazepine. Impotence persisted with phenobarbi

Health consequences of anabolic steroids: a sexual-medicine perspective.

Nonmedical anabolic-androgenic steroid (AAS) use is increasingly encountered in sexual medicine practice, often presenting through sexual symptoms or fertility concerns rather than overt systemic illness. This review summarizes the major health consequences of AAS abuse with emphasis on sexual and reproductive sequelae and provides a pragmatic approach to evaluation and recovery after cessation. AAS exposure commonly suppresses the hypothalamo-pituitary-gonadal axis, leading to hypogonadism and hormonal imbalance that may manifest as reduced libido, erectile dysfunction, gynecomastia, and impa…

Protective effects of Coridius chinensis extracts on rat reproductive damage induced by manganese.

Manganese (Mn2+ ) is an environmental pollutant, and testis is one of the main target organs. Coridius chinensis (C. chinensis), a traditional Chinese medicine, has been shown widely used in treating various kinds of pain, nephropathy and erectile dysfunction. In our recent study, we found that Mn2+ exposure caused testicular injury could be rescued in part by the antioxidant activity of C. chinensis extracts (CcE). However, there is dearth of extensive knowledge on the therapeutic effects of C. chinensis on manganese-induced reproductive toxicity. In the present study, Sprague-Dawley (SD) rat…

A rare case of galactocele in a patient with macroprolactinoma. The hypothetical role of poor compliance with dopamine agonist therapy.

Galactocele is a rare clinical finding in males and is even more uncommon in the context of prolactin-secreting pituitary adenomas. Its occurrence raises important questions about the effects of hyperprolactinemia in men, especially when there is poor treatment adherence. We describe a 34-year-old man with type 2 diabetes who presented with erectile dysfunction, gynecomastia, and galactorrhea. Investigations confirmed hyperprolactinemia secondary to a pituitary macroadenoma. He was started on cabergoline, which improved his symptoms. However, after discontinuing therapy for several months, he …