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Неврологические болезни: почему пол и пол материи.

В неврологии все чаще признается, что упругость оказывает влияние на подверженность заболеваниям, прогресс и результаты. Появляющиеся данные свидетельствуют о ключевой роли секса и пола в формировании хрупких траекторий основных неврологических расстройств, включая инсульт, болезнь Паркинсона, слабоумие и множественный склероз. В рамках этого систематического обзора обобщаются имеющиеся в настоящее время знания о взаимосвязи между слабостью и неврологическими заболеваниями с уделением особого внимания особенностям пола. Признание различий по признаку пола и пола в слабом выражении имеет решающ

Совпадение в аннотации оригинала
Frailty is increasingly recognized as a critical factor in neurology, influencing disease susceptibility, progression, and outcomes. Emerging evidence highlights the pivotal role of sex and gender in shaping frailty trajectories across major neurological disorders, including stroke, Parkinson's disease (PD), dementia, and multiple sclerosis. This systematic …

Точность клинических оценок с виртуальным лечением в амбулаторной неврологии.

Виртуальные неврологические оценки все шире используются во время пандемии COVID-19 с относительно неизвестной точностью. В период с 23 марта 2020 по 23 марта 2021 года в одной из учебных больниц была проведена проверка больничных записей в основной склерозовой амбулаторной клинике. Проверенные пациенты прошли первоначальную виртуальную оценку, за которой последовала последующая личностная оценка. Из 1036 проанализированных пациентов 27,8 процента (n = 288) консультаций были проведены с помощью видеотелеконференцсвязи и 72,2 процента (n = 748) - по телефону. В целом 86,2% консультаций выявили

Молекулярный механизм паноптоза и запрограммированной смерти клеток от неврологических заболеваний.

PANoptosis представляет собой высоко скоординированную запрограммированную смерть клеток, регулируемую сборкой и активацией PANoptosome, которая стратегически объединяет основные молекулярные элементы от пироптоза, апоптоза и некроптоза. Трехкомпонентные пути смерти в клетках отличались от альтернативных регулируемых механизмов смерти в клетках благодаря их уникальной способности одновременно интегрировать и обрабатывать молекулярные сигналы, полученные в результате множественных способов смертного сигнала, тем самым координируя многогранную систему сотовой защиты от различных патологических о

Совпадение в аннотации оригинала
PANoptosis represents a highly coordinated inflammatory programmed cell death governed by the assembly and activation of PANoptosome, which … e regulatory networks, and proposes PANoptosis-targeted therapeutic frameworks to advance precision neurology.

Atypical neurological symptoms at high altitude: a systematic literature review.

BACKGROUND: Acute Mountain Sickness (AMS) is a prevalent and potentially debilitating condition affecting individuals who participate in high-altitude journeys, mostly above 2500 m. The main symptoms of AMS, listed in the Lake Louise Symptom score used to diagnose AMS, are headache, dizziness, nausea, and fatigue. However, mountaineering can also be associated with other neurological disturbances. Most records related to neurological disorders associated with high-altitude medicine focus on AMS and its typical neurological symptoms indicated in official criteria. Other conditions related to ac

An adapted Danish translation of the Center for Neurologic Study Lability scale.

INTRODUCTION: Pathological crying and/or laughing (pseudobulbar affect (PBA)) are socially debilitating symptoms seen in many neurological diseases, such as stroke, multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS). One method for measuring the degree of PBA is the Center for Neurologic Study-Lability Scale (CNS-LS), a seven-item questionnaire validated for quantifying symptoms and supporting PBA diagnoses in ALS and MS. The aim of this study was to provide a Danish translation of the CNS-LS inspired by international guidelines on cross-cultural translation and adaptation of self

Тайрозин Брютона: потенциальная новая цель для неврологических расстройств.

Тирозиновая киназа Брютона (BTK) является важной частью канала сигнала B-клектора, который широко изучался при различных видах недугов. Недавние исследования расширили наши знания о его роли в метаболизме, а также в неврологических расстройствах. Она может играть важную роль в патофизиологии неврологических заболеваний, таких как множественный склероз, болезнь Альцгеймера, повреждение мозга и несколько других. Активация воспалений, главным образом NLRP3, является одним из основных механизмов, с помощью которого она поощряет воспаление мозга, связанное со старением и болезнями. В настоящем доку

New insights into sodium phenylbutyrate as a pharmacotherapeutic option for neurological disorders.

Neurological disorders (NDs) are diseases of the central and peripheral nervous systems that affect more than one billion people worldwide. The risk of developing an ND increases with age due to the vulnerability of the different organs and systems to genetic, environmental, and social changes that consequently cause motor and cognitive deficits that disable the person from their daily activities and individual and social productivity. Intrinsic factors (genetic factors, age, gender) and extrinsic factors (addictions, infections, or lifestyle) favor the persistence of systemic inflammatory pro

PIWI-Interacting RNAs: A Pivotal Regulator in Neurological Development and Disease.

PIWI-interacting RNAs (piRNAs), a class of small non-coding RNAs (sncRNAs) with 24-32 nucleotides (nt), were initially identified in the reproductive system. Unlike microRNAs (miRNAs) or small interfering RNAs (siRNAs), piRNAs normally guide P-element-induced wimpy testis protein (PIWI) families to slice extensively complementary transposon transcripts without the seed pairing. Numerous studies have shown that piRNAs are abundantly expressed in the brain, and many of them are aberrantly regulated in central neural system (CNS) disorders. However, the role of piRNAs in the related developmental

Brain-computer interfaces: the innovative key to unlocking neurological conditions.

Neurological disorders such as Parkinson's disease, stroke, and spinal cord injury can pose significant threats to human mortality, morbidity, and functional independence. Brain-Computer Interface (BCI) technology, which facilitates direct communication between the brain and external devices, emerges as an innovative key to unlocking neurological conditions, demonstrating significant promise in this context. This comprehensive review uniquely synthesizes the latest advancements in BCI research across multiple neurological disorders, offering an interdisciplinary perspective on both clinical ap

A causal link between autoantibodies and neurological symptoms in long COVID.

Acute SARS-CoV-2 infection triggers the generation of diverse and functional autoantibodies (AABs), even after mild cases. Persistently elevated autoantibodies have been found in some individuals with long COVID (LC). Using a >21,000 human protein array, we identified diverse AAB targets in LC patients that correlated with their symptoms. Elevated AABs to proteins in the nervous system were found in LC patients with neurocognitive and neurological symptoms. Purified Immunoglobulin G (IgG) samples from these individuals reacted with human pons tissue and were cross-reactive with mouse sciatic n

Association of LEF1-AS1 with cardiovascular and neurological complications of COVID-19.

A significant proportion of COVID-19 patients develop long-term complications, particularly cardiovascular and neurological issues. Even though risk factors for developing complications after COVID-19 have been identified, a biomarker to predict these complications could enable personalized healthcare and potentially reduce the disease burden. Easily measurable in the blood, the long noncoding RNA LEF1-AS1 has recently been associated with in-hospital mortality following SARS-CoV - 2 infection and holds potential as a biomarker for disease severity in COVID-19 patients. Consequently, we examin

Extracellular vesicles: Mediators of microenvironment in hypoxia-associated neurological diseases.

Hypoxia is a prevalent characteristic of numerous neurological disorders including stroke, Alzheimer's disease, and Parkinson's disease. Extracellular vesicles (EVs) are minute particles released by cells that contain diverse biological materials, including proteins, lipids, and nucleic acids. They have been implicated in a range of physiological and pathological processes including intercellular communication, immune responses, and disease progression. EVs are believed to play a pivotal role in modulating the microenvironment of hypoxia-associated neurological diseases. These EVs are capable

Non-Invasive Brain Sensing Technologies for Modulation of Neurological Disorders.

The non-invasive brain sensing modulation technology field is experiencing rapid development, with new techniques constantly emerging. This study delves into the field of non-invasive brain neuromodulation, a safer and potentially effective approach for treating a spectrum of neurological and psychiatric disorders. Unlike traditional deep brain stimulation (DBS) surgery, non-invasive techniques employ ultrasound, electrical currents, and electromagnetic field stimulation to stimulate the brain from outside the skull, thereby eliminating surgery risks and enhancing patient comfort. This study e

Neurological Complications Following Cardiac Surgery: Management and Future Directions.

Neurological complications related to cardiac surgery present physicians with challenges. These complications severely impact patients' outcomes, the quality of their lives, and affect the resources available at healthcare centers. The treatment of neurological complications requires a multidisciplinary approach, where evidenced-based interventions work to identify the patient profiles and risk factors. In addition, ongoing investigations on alternative treatment methods like cerebral oximetry and personalized risk stratification may likely improve management and outcomes of such high-risk pat

The Impact of Pulmonary Disorders on Neurological Health (Lung-Brain Axis).

The brain and lungs, vital organs in the body, play essential roles in maintaining overall well-being and survival. These organs interact through complex and sophisticated bi-directional pathways known as the 'lung-brain axis', facilitated by their close proximity and neural connections. Numerous studies have underscored the mediation of the lung-brain axis by inflammatory responses and hypoxia-induced damage, which are pivotal to the progression of both pulmonary and neurological diseases. This review aims to delve into how pulmonary diseases, including acute/chronic airway diseases and pulmo

Evaluation of thyroid function tests among children with neurological disorders.

BACKGROUND: Thyroid hormones (THs) are essential for brain development. Numerous studies have identified significant links between thyroid dysfunction and cognitive function. However, research on the significance and necessity of thyroid function tests in diagnosis of neurological disorders is limited and subject to controversy. METHODS: Our study employed a combination of meta-analysis and case-control design. For the meta-analysis, we conducted a systematic search of online databases for studies that compared thyroid function tests in children with neurological disorders to controls. In our

Public health trends in neurologically relevant infections: a global perspective.

Neuroinfectious diseases represent a growing threat to public health globally. Infections of the central nervous system remain challenging to diagnose and treat, partially driven by the fact that a high proportion of emerging pathogens are capable of causing neurological disease. Many of the trends driving the emergence of novel pathogens, including climate change, ecological degradation, urbanization, and global travel, have accelerated in recent years. These circumstances raise concern for the potential emergence of additional pathogens of pandemic potential in the coming years, necessitatin

Oxygen extraction fraction (OEF) values and applications in neurological diseases.

One of the goals of this systematic review is to provide a meta-analysis-derived mean OEF of healthy volunteers. Another aim of this study is to indicate the OEF ranges of various neurological pathologies. Potential clinical applications of OEF metrics are presented. Peer-reviewed studies reporting OEF metrics derived from computed tomography (CT)/positron emission tomography (PET) and/or magnetic resonance imaging (MRI) were considered. Databases utilized included MEDLINE, PubMed, EMBASE, Web of Science, and Google Scholar. The Newcastle-Ottawa scoring system was used for evaluating studies.

Costs Are Still on the Rise for Commonly Prescribed Branded Neurologic Medications.

OBJECTIVES: To observe medication cost trends for 5 common neurologic conditions. METHODS: We quantified annual out-of-pocket (OOP) and total medication costs for patients seen by a neurologist with epilepsy, multiple sclerosis (MS), Parkinson disease (PD), peripheral neuropathy (PN), and dementia/Alzheimer's disease in a commercial claims database cross-sectionally from 2012 to 2021. RESULTS: We identified 186,144 patients with epilepsy, 54,676 with MS, 45,909 with PD, 169,127 with PN, and 60,861 with dementia/Alzheimer. OOP costs for MS medications increased each year, by 217% on average.

Neurological care and outcomes in a cohort of Canadian pregnant patients with epilepsy.

PURPOSE: To characterize anti-seizure medication (ASM) use over time, therapeutic drug monitoring, ASM dose adjustments and gestational seizure frequency among Canadian people with epilepsy of childbearing potential seen in an urban tertiary care center. METHODS: Participants were retrospectively identified from the medical records of pregnant patients with epilepsy seen at the University Health Network Comprehensive Epilepsy Program between 2014 and 2021. A descriptive analysis of outcomes, a logistic regression analysis of the odds of patients being on three ASMs associated with higher rate