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Куркумин влияет на синтез хитина в Aedes aegypti: вычислительное и экспериментальное исследование.

На протяжении всей истории трансмиссивые заболевания неизменно создавали серьезные проблемы для здоровья человека. В рамках стратегий борьбы с переносчиками химических инсектицидов с момента их создания широко применяются. Тем не менее их эффективность постоянно подрывается устойчивым ростом резистентности к инсектицидам среди этих переносчиков. Спрос на более надежные, эффективные и рентабельные природные инсектициды как таковые становится все более насущным. Одним из многообещающих направлений исследований является шитин, который является важнейшим структурным компонентом экзоскелетов комаро

Совпадение в аннотации оригинала
Throughout history, vector-borne diseases have consistently posed significant challenges to human health. Among the strategies for vector co … synthesis and larval development in Aedes aegypti, a mosquito species known to transmit dengue and yellow fever. Our findings demonstrate that even sub-lethal amounts of curcumin can significantly reduce overall chitin content and disrupt the cuticle development in the 4th instar larvae of Aedes aegypti. Further to this, we utilized computational analyses to …

Огромный желчный камень, сложный циррозом печени у женщины среднего возраста: отчет по делу.

Галлстоуны все чаще становятся общим диагнозом в больницах на всех континентах, где преобладают женщины. Пациенты, подозреваемые в болезни желчного камня, нуждаются в тщательной оценке, включая эндоскопический ультразвуковой аппарат, магнитный резонансный снимок или магнитный резонанс-холангиографию. Отсроченный или пропущенный диагноз связан с серьезными осложнениями и плохим прогнозом. КИСЛОТА: 44-летняя пациентка в течение 10 дней страдала лихорадкой, рвотой, ипохондрией и эпигастической болью. Клиническое обследование показало, что яму и нежность в правой области ипохондриака. Анализ крови

Physical Attributes of Tree Holes in the Atlantic Forest Edges: Evaluating Their Association with the Presence and Abundance of Immature Haemagogus leucocelaenus.

Sylvatic yellow fever (SYF) was recently a health issue in Brazil (2016-2019) because transmission was facilitated by a high density of vectors, amplifying hosts, and low vaccine coverage of the human population, especially in urban forests in the Southeast Region of Brazil. Moreover, urban forest edges are more likely to have contact between human and sylvatic vector mosquito populations. Here, we show the association between abiotic and biotic features of tree holes as Haemagogus leucocelaenus rearing sites in Cantareira State Park in Atlantic Forest edges. The analyzed physical features of …

Immunization status in patients with multiple sclerosis: A cross-sectional, monocenter study in Austria.

BACKGROUND AND PURPOSE: Patients with multiple sclerosis (MS) under certain disease-modifying therapies (DMT) show a higher risk of infectio … ainst influenza (10%), pneumococcal (6%) and meningococcal disease (4%), human papillomavirus (4%), yellow fever (2%), and varicella zoster virus (1%). A total of 87% received vaccination against SARS-CoV-2. Overall, higher vaccination rates were associated with younger age, relapsing disease course, and education level. Misinformation on infectious diseases a …

Timeliness of Vaccination among Children Attending Immunization Clinic at a Tertiary Hospital in South-East Nigeria.

BACKGROUND: Timely vaccination of children is one of the most cost-effective interventions that ensure childhood survival. We determined the … 0 within 24 hours of birth. Only 65.7% and 65.0% received the timely measles-containing vaccine and yellow fever vaccine. None of the factors examined predicted timely receipt of BCG and Penta 3 vaccines. CONCLUSION: Interventions that remind caregivers about the immunization schedules, could improve timely vaccination.

Ultrasound-assisted nanoemulsion of Trachyspermum ammi essential oil and its constituent thymol on toxicity and biochemical aspect of Aedes aegypti.

Aedes aegypti is the main vector of yellow fever, chikungunya, Zika, and dengue worldwide and is managed by using chemical insecticides. Though effective, their indiscriminate use brings in associated problems on safety to non-target and the environment. This supports the use of plant-based essential oil (EO) formulations as they are safe to use with limited effect on non-target organisms. Quick volatility and degradation of EO are a hurdle in its use; the present study attempts to develop nanoemulsions (NE) of Trachyspermum ammi EO and its constituent thymol using Tween 80 as surfactant by ul…

Ecological Characterization of Mosquitoes (Diptera: Culicidae) at the Southern Coast of Mar Chiquita Lake, Argentina.

In the southern coast of Mar Chiquita Lake, central Argentina, mosquitoes affect public health and community livelihood, since they transmit pathogens to human beings causing diseases such as malaria, filariasis, encephalitis, yellow fever, and dengue, among others, and have a negative effect on cattle farming as well. To characterize the structure of the mosquito assemblage of the region, we determined the species composition and diversity, the temporal distribution of different species, and the patterns of species richness, abundance, and diversity across seasons. We collected adult mosquito…

5-(Perylen-3-ylethynyl)uracil as an antiviral scaffold: Potent suppression of enveloped virus reproduction by 3-methyl derivatives in vitro.

Amphipathic nucleoside and non-nucleoside derivatives of pentacyclic aromatic hydrocarbon perylene are known as potent non-cytotoxic broad-spectrum antivirals. Here we report 3-methyl-5-(perylen-3-ylethynyl)-uracil-1-acetic acid and its amides, a new series of compounds based on a 5-(perylen-3-ylethynyl)-uracil scaffold. The compounds demonstrate pronounced in vitro activity against arthropod-borne viruses, namely tick-borne encephalitis virus (TBEV) and yellow fever virus (YFV), in plaque reduction assays with EC50 values below 1.9 and 1.3 nM, respectively, and Chikungunya virus (CHIKV) in cy…

Quantitative Trait Locus Determining the Time of Blood Feeding in Culex pipiens (Diptera: Culicidae).

Mosquitoes and other blood feeding arthropods are vectors of pathogens causing serious human diseases, such as Plasmodium spp. (malaria), Wuchereria bancrofti (lymphatic filariasis), Borrelia burgdorferi (Lyme disease), and viruses causing dengue, Zika, West Nile, chikungunya, and yellow fever. Among the most effective strategies for the prevention of vector-borne diseases are those aimed at reducing human-vector interactions, such as insecticide applications and insecticide-treated bed nets (ITNs). In some areas where ITNs are widely used, behavioral adaptations have resulted in mosquitoes sh…

Outcome of reminder text messages intervention on completion of routine immunization in rural areas, Nigeria.

Completion of routine immunization for infants has been a challenge in Nigeria, and existing strategies implemented to promote immunization … accine was found. The Intervention group had a significantly higher completion rate for measles and yellow fever vaccines (55.3%; 75.9%) compared with the Control group (26.8%; 23.9%). Qualitative findings revealed positive comments from mothers in the intervention group that the messages increase awareness of immunization dates, assisted in readjusting their …

Spatiotemporal multiple insecticide resistance in Aedes aegypti populations in French Guiana: need for alternative vector control.

BACKGROUND: Aedes aegypti is the sole vector of urban arboviruses in French Guiana. Overtime, the species has been responsible for the transmission of viruses during yellow fever, dengue, chikungunya and Zika outbreaks. Decades of vector control have produced resistant populations to deltamethrin, the sole molecule available to control adult mosquitoes in this French Territory. OBJECTIVES: Our surveillance aimed to provide public health authorities with data on insecticide resistance in Ae. aegypti populations and other species of interest in French Guiana. Monitoring resistance to the insect…

Эпидемия вируса Майаро в Америке: систематический обзор и ключевые оценки параметров для моделирования вспышек.

Вирус Майаро (MAYV) — арбовирус, эндемичный для тропических лесов в Центральной и Южной Америке, особенно в бассейне Амазонки. В последние годы усилилась обеспокоенность по поводу способности МАЙВ вторгаться в городские районы и вызывать эпидемии во всем регионе. Мы провели систематический обзор литературы, чтобы охарактеризовать историю эволюции MAYV, его трансмиссионный потенциал и модели воздействия вируса. Мы проанализировали данные из литературы по инфекциям MAYV, с тем чтобы получить оценки ключевых эпидемиологических параметров, включая время производства и базовое количество репродукци

Совпадение в аннотации оригинала
Mayaro virus (MAYV) is an arbovirus that is endemic to tropical forests in Central and South America, particularly within the Amazon basin. … smission. MAYV's enzootic cycle could become established in forested areas within cities similar to yellow fever virus.

Genetic stability of Aedes aegypti populations following invasion by wMel Wolbachia.

BACKGROUND: Wolbachia wMel is the most commonly used strain in rear and release strategies for Aedes aegypti mosquitoes that aim to inhibit the transmission of arboviruses such as dengue, Zika, Chikungunya and yellow fever. However, the long-term establishment of wMel in natural Ae. aegypti populations raises concerns that interactions between Wolbachia wMel and Ae. aegypti may lead to changes in the host genome, which could affect useful attributes of Wolbachia that allow it to invade and suppress disease transmission. RESULTS: We applied an evolve-and-resequence approach to study genome-wid…

The limited knowledge of placental damage due to neglected infections: ongoing problems in Latin America.

UNLABELLED: The placenta works as a selective barrier, protecting the fetus from potential infections that may affect the maternal organism … ascular endothelial growth factor; VL: visceral leishmaniasis; WHO: world health organization; YFV: yellow fever virus; ZIKV: Zika virus.

Biting deterrency of undecanoic acid and dodecanoic acid ester analogs against Aedes aegypti.

BACKGROUND: Mosquitoes remain one of the most significant threats to the health of humans throughout the world. This study was designed to evaluate the biting deterrent effects of a series of ester analogs of undecanoic acid (C:11:0) and dodecanoic acid (C:12:0) against Aedes aegypti (L), (Diptera: Culicidae), the yellow fever mosquito, using Klun and Debboun (K&D) and Ali and Khan (A&K) bioassay systems. RESULTS: In the K&D bioassays, C:11:0 esters methyl undecanoate, propyl undecanoate, butyl undecanoate, and pentyl undecanoate, and the C:12:0 esters methyl dodecanoate, ethyl dodecanoate, p…

Геномная транскриптомная профиллинговая система Genes связана с Meiotic Drive System of Aedes aegypti.

Aedes aegypti — важный переносчик комаров из нескольких арбовирусов, включая денге, желтую лихорадку, Зику и Чикунгуню, которые вызывают значительную человеческую заболеваемость и смертность во всем мире. В некоторых популяциях комаров мейотическая система привода вызывает аномальный сперматогенез, который приводит к тому, что некоторые спаренные потомки в значительной степени мужские. Хотя основные генетики и цитогенетики привода были разъяснены, на уровне транскриптома очень мало известно о том, как мейотный фенотип привода выражается у отдельных самцов. Для решения этого вопроса мы провели

Совпадение в аннотации оригинала
Aedes aegypti is an important mosquito vector of several arboviruses, including dengue, yellow fever, Zika, and Chikungunya, which cause significant human morbidity and mortality globally. In certain populations of this mosquito, a native meiotic drive system causes abnormal spermatogenesis that results in highly male-biased progenies from some matings. Alth…

Laboratory Evaluation of Larvicidal and Oviposition Deterrent Properties of Edible Plant Oils for Potential Management of Aedes aegypti (Diptera: Culicidae) in Drinking Water Containers.

The yellow fever mosquito, Aedes aegypti (Diptera: Culicidae) transmits several devastating arboviruses, including dengue, chikungunya, and Zika virus, making development of inexpensive and eco-friendly strategies for its control an urgent priority. We evaluated the lethality of 13 commonly used plant-derived edible oils against late-third instar Ae. aegypti and then tested the three most lethal oils for stage-specific differences in lethality. We also examined the effects of the most lethal (hempseed), moderately lethal (sunflower and peanut), and least lethal (olive) oils on survival to adul…

Determinants of childhood immunizations in Senegal: Adding previous shots to sociodemographic background.

Introduction. Today, in Sub-Saharan Africa, vaccine-preventable diseases still contribute heavily to high child mortality. Maintaining high … inants of several childhood vaccinations (Bacillus Calmette-Guérin, pentavalent, polio, measles and yellow fever vaccines), including sociodemographic factors and previous shots.Results. We identified two main sociodemographic predictors of childhood vaccination in Senegal: the mother's education level, which was strongly and positively correlated to every vac …

Consensus and uncertainty in the geographic range of Aedes aegypti and Aedes albopictus in the contiguous United States: Multi-model assessment and synthesis.

Aedes (Stegomyia) aegypti (L.) and Ae. (Stegomyia) albopictus (Skuse) mosquitoes can transmit dengue, chikungunya, yellow fever, and Zika viruses. Limited surveillance has led to uncertainty regarding the geographic ranges of these vectors globally, and particularly in regions at the present-day margins of habitat suitability such as the contiguous United States. Empirical habitat suitability models based on environmental conditions can augment surveillance gaps to describe the estimated potential species ranges, but model accuracy is unclear. We identified previously published regional and gl…

Characterization of potential biomarkers of reactogenicity of licensed antiviral vaccines: randomized controlled clinical trials conducted by the BIOVACSAFE consortium.

Biomarkers predictive of inflammatory events post-vaccination could accelerate vaccine development. Within the BIOVACSAFE framework, we conducted three identically designed, placebo-controlled inpatient/outpatient clinical studies (NCT01765413/NCT01771354/NCT01771367). Six antiviral vaccination strategies were evaluated to generate training data-sets of pre-/post-vaccination vital signs, blood changes and whole-blood gene transcripts, and to identify putative biomarkers of early inflammation/reactogenicity that could guide the design of subsequent focused confirmatory studies. Healthy adults (