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Lesion viral burden, multidrug-resistant superinfection, and HIV-associated haematological vulnerability in hospitalised clade Ib mpox: a prospective cohort study in Uganda.

BACKGROUND: Mpox has shifted to sustained human-to-human transmission across Africa, yet integrated triage incorporating viral burden, bacterial co-infection, antimicrobial resistance (AMR), HIV status, and routine biomarkers remain scarce. METHODS: At Uganda's national mpox referral hospital, we prospectively enrolled 155 adults at 14 ± 2 days post-symptom onset; mpox was confirmed by lesion-swab qPCR (F3L), with clade assignment by whole-genome sequencing in a prespecified subset (March-April 2025). Lesion viral DNA burden was estimated using qPCR cycle threshold (Ct) values. Purulent lesio…

Адаптивное, поэтапное ограждение от связанных с раком симптомов ПТСР у выживших жертв HCT: результаты испытания SMART.

ЦЕЛЬ: посттравматическое стрессовое расстройство, связанное с раком (ПТСР), широко распространено среди выживших жертв пересадки клеток (ГХТ), однако доступ к лечению, основанному на фактических данных, ограничен. В ходе этого исследования была проведена оценка адаптивных и ступенчатых методов лечения симптомов ПТСР с использованием метода многоразового испытания на последовательность заданий (СМАРТ), сравнивая цифровое и психотерапевтическое вмешательство. МЕТОДЫ: Выжившие жертвы НТС (N = 477), 1-5 Годы после трансплантации с вероятным или подпороговым посттравматическим ПТСР были случайными

Совпадение в аннотации оригинала
OBJECTIVE: Cancer-related posttraumatic stress disorder (PTSD) is prevalent among hematopoietic cell transplantation (HCT) survivors, yet ac … digital intervention did not outperform Usual Care initially, adaptive stepped-care strategies that triage early responders and escalate non-responders to therapist-delivered CBT-PTSD were associated with the greatest reductions in symptoms. Digital tools may function as entry points within stepped-care models to allocate higher-intensity psychotherapy. …

When morphology suggests a fusion: A pathology-centered escalation framework from histology and immunohistochemistry to RNA sequencing.

Gene fusions have moved from ancillary molecular findings to defining events for an expanding group of neoplasms, with consequences for tumo … ations and morphology-immunophenotype discordance. We then position immunohistochemistry (IHC) as a triage layer rather than a molecular surrogate in all cases, emphasizing marker specificity, clone- and platform-dependent performance, and the distinction between screening and near-diagnostic surrogate markers. The relative roles of fluorescence in situ …

Noninvasive detection and differentiation of gastric malignancy using cell-free DNA biomarkers.

INTRODUCTION: Gastric cancer remains a major global health burden, with high mortality driven by late-stage diagnoses that limit treatment o … n high-risk or symptomatic patients. This approach demonstrates strong potential as a pre-endoscopy triage tool, supporting earlier detection and more efficient use of diagnostic resources.

Pancreatic Cancer Screening in Patients with Type 2 Diabetes Mellitus: A Narrative Review.

Pancreatic ductal adenocarcinoma (PDAC) remains a high-burden disease worldwide with increasing incidence, poor prognosis, and high mortalit … ight loss, rapid HbA1c escalation/insulin initiation) and predictive risk scores (e.g., ENDPAC) can triage NOD patients for magnetic resonance imaging/computed tomography (MRI/CT) and endoscopic ultrasound (EUS). A targeted screening approach may allow early diagnosis that could improve the prognosis of PDAC patients. This narrative review aims to synthe …

Survival outcomes and prognostic indicators in canine pancreatitis: A retrospective cohort study of acute kidney injury and concurrent diseases.

BACKGROUND AND AIM: Canine pancreatitis is often complicated by acute kidney injury (AKI) and systemic comorbidities, both of which may wors … ystemic diseases. Readily available markers, such as HCT and BCR, provide practical tools for early triage and prognostic stratification. Incorporating these parameters into clinical decision-making may enhance outcomes by guiding intensive monitoring and targeted interventions.

Tutorial on Multiple Mediation Analysis Using Causal Networks: Application to Diagnosing COVID-19 From Its Early and Late Symptoms.

BACKGROUND AND OBJECTIVES: There are two methods of studying multiple mediation: network-based and analysis of coefficients in regression eq … gressions into a single network model. The procedure showed how artificial intelligence can help in triage of COVID-19 patients from their symptoms, before any home or laboratory tests.

Correlation of HPV Status with Colposcopy and Cervical Biopsy Results Among Non-Vaccinated Women: Findings from a Tertiary Care Hospital in Kazakhstan.

Background/Objectives: Cervical cancer is one of the most frequent malignancies among women in Kazakhstan, where human papillomavirus (HPV) … lent vaccination. These findings highlight the importance of HPV-based screening, genotype-specific triage, and expanded vaccination to reduce cervical cancer incidence in Kazakhstan.

Validation of an Integrated Clinical Biomarker Diagnostic Model for Acute Pancreatitis: Incorporating Trypsinogen-Activating Peptide and Trypsin-2 in a Romanian Population Study.

Introduction: Severe acute pancreatitis (SAP) is a critical condition that affects 20-30% of people with acute pancreatitis (AP). Prompt det … . Combining indicators of local pancreatic involvement with systemic inflammation allows for prompt triage, improves the allocation of intensive therapy, and supports informed prognostic conversations.

"If your CD4 count lowers, that is when you are similar to a person that is non-existent" A qualitative exploration of perceptions around advanced HIV disease in South Africa.

BACKGROUND: Despite widespread availability and differentiated delivery of antiretroviral treatment (ART), advanced HIV disease (AHD) remains prevalent, with high mortality risk. In South Africa, we assessed perceptions about the meaning of AHD and social and behavioural factors influencing AHD development. METHODS: In-depth interviews were conducted with 13 PWH screened for AHD during a community-based tuberculosis triage trial, and five stakeholders involved in policy-making or implementation of AHD-related programmes. Two focus group discussions were conducted with seven study nurses and t…

Cost-utility analysis of a tiered diagnostic approach combining a screening model and polysomnography in pediatric obstructive sleep apnea.

STUDY OBJECTIVES: Obstructive sleep apnea (OSA) is a common disorder in the pediatric population, primarily diagnosed through polysomnograph … parameters confirmed the robustness of these results. CONCLUSIONS: Using the screening model as a triage tool for PSG enhances the cost-effectiveness of pediatric OSA management. CITATION: Xu S, Li Y, Han D. Cost-utility analysis of a tiered diagnostic approach combining a screening model and polysomnography in pediatric obstructive sleep apnea. J Cli …

Early detection of cytokine storm and IgG levels to predict and prevent severe COVID-19 infection.

BACKGROUND: The mortality of COVID-19 is largely the result of cellular injury and inflammation of pulmonary and nonpulmonary vital tissue a … IFN-γ gene expression study through a multiplex qRTPCR assay and the D-dimer test as rapid tools to triage COVID-19 patients during management and identify need for escalating therapy.

Performance of Older Adults on the Digital Clock and Recall Test Compared to the Montreal Cognitive Assessment in Primary Care Settings.

BACKGROUND: Digital cognitive assessment solutions can overcome some barriers to cognitive screening in primary care by providing rapidly ob … r Alzheimer's disease, the DCR and similar digital cognitive assessment tools have the potential to triage patients for both Alzheimer's disease diagnostic workups and subsequent treatments beyond specialty care.

Integrating Feature Selection, Machine Learning, and SHAP Explainability to Predict Severe Acute Pancreatitis.

Background/Objectives: Severe acute pancreatitis (SAP) carries substantial morbidity and resource burden, and early risk stratification rema … data available at ED arrival. The approach highlights actionable predictors and may support earlier triage and resource allocation; external validation is warranted.

Comprehensive Analysis of Heart Failure Subtypes Presenting at Emergency Department for Acute Heart Failure Management.

INTRODUCTION: Despite advances in echocardiography and biomarkers, the pathophysiological complexities among heart failure categories remain incompletely understood. This study analyzed patients' characteristics across heart failure with reduced ejection fraction, heart failure with midrange ejection fraction, and heart failure with preserved ejection fraction presenting at the emergency department. METHODS: This is a retrospective analysis of 954 patients with acute heart failure (2016-2023) using electronic health records. Data were collected from patient triage and the emergency department…

Neuroemergencies Management and Transfers System: Safety and Efficacy in Intracerebral Hemorrhage Patient Transfer During COVID-19 Pandemic.

OBJECTIVE: Intracerebral hemorrhage (ICH) carries significant morbidity and mortality. Efficient, resilient triage and transfer systems are critical, especially during global crises such as the COVID-19 pandemic. This study evaluates the Neuroemergencies Management and Transfers (NEMAT) program's safety and effectiveness for ICH patients requiring interhospital transfers (IHT), comparing immediate and long-term outcomes, symptomatic postoperative rebleed, home discharge, 30-day mortality, and 6-month modified Rankin Scale (mRS) scores between NEMAT and direct emergency department (ED) admissio…

Abdominal fluid score as a predictor of transfusion needs and outcome in cats following trauma.

OBJECTIVE: To assess the value of the abdominal fluid score (AFS) in cats following trauma in determining surgical needs, transfusion needs, … ithout abdominal effusion (negative AFS [nAFS]). pAFS cats also had a higher baseline Animal Trauma Triage score (ATTS) than nAFS cats (5, range 0-12 vs 3, range 0-17, respectively, P < 0.001). pAFS cats were more likely to require blood transfusions (16% [23/148] vs 4% [94/2161], P < 0.001) than nAFS cats, but need for surgical intervention did not diff …

The impact of COVID-19 on patterns of burns evaluated in pediatric emergency departments.

BACKGROUND: Fire- and burn-related injuries are among the top 10 causes of death for children < 18 years in the United States and are associ … distribution of burn visits in 2020 (p < 0.001) and significantly higher proportions of more urgent triage levels (p <0.05) and trauma activations (p < 0.05). Body region affected (p < 0.01), intent (p < 0.001) and mechanism (p < 0.001) also differed significantly. A higher proportion were due to flames/fires and fewer due to hot objects. CONCLUSIONS: B …

Words to live by: Using medic impressions to identify the need for prehospital lifesaving interventions.

BACKGROUND: Prehospital emergencies require providers to rapidly identify patients' medical condition and determine treatment needs. We test … showed that models could prioritize correct LSI identification (i.e., high sensitivity) or accurate triage (i.e., low false-positive rate). Sensitivity analyses showed that model performance was robust when removing from medic impressions words that directly labeled an LSI. CONCLUSIONS: ML based on free-text medic impressions can help identify patient n …

CK/Albumin and K/Ca ratios as predictors of clinical severity and renal replacement therapy in pediatric crush syndrome.

BACKGROUND: Crush syndrome after earthquakes is life-threatening. In pediatric patients, prognostic indicators for severe course and renal r … These parameters may aid early risk stratification in disaster-related pediatric trauma and support triage in clinical practice.